Modulation of the inflammation-coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: Role of Toll-like receptor 2
The present study evaluated the effect of nasally given Lactobacillus rhamnosus CRL1505 on the immunocoagulative response during pneumococcal infection in immunocompetent mice. In addition, we aimed to gain insight into the mechanism involved in the immunomodulatory effect of the L. rhamnosus CRL150...
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| Veröffentlicht in: | Microbiology and immunology 2014-07, Vol.58 (7), p.416-426 |
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| creator | Zelaya, Hortensia Villena, Julio Lopez, Andres Gramajo Alvarez, Susana Agüero, Graciela |
| description | The present study evaluated the effect of nasally given Lactobacillus rhamnosus CRL1505 on the immunocoagulative response during pneumococcal infection in immunocompetent mice. In addition, we aimed to gain insight into the mechanism involved in the immunomodulatory effect of the L. rhamnosus CRL1505 strain by evaluating the role of TLR2. Results showed that nasally given L. rhamnosus CRL1505 effectively regulates inflammation and hemostatic alterations during the pneumococcal infection. Immunobiotic treatment significantly reduced permeability of the bronchoalveolar–capillary barrier, and general cytotoxicity, decreasing lung tissue damage. The CRL1505 strain improved the production of TNF‐α, IFN‐γ, and IL‐10 after pneumococcal challenge. In addition, increased TM and TF expressions were found in lungs of L. rhamnosus CRL1505‐treated mice. Moreover, we demonstrated, for the first time, that the TLR2 signaling pathway has a role in the induction of IFN‐γ and IL‐10 and in the reduction of TF. The results also allow us to speculate that a PRR, other than TLR2, may mediate the immunobiotic activity of L. rhamnosus CRL1505 and could explain changes in TNF‐α and TM. |
| doi_str_mv | 10.1111/1348-0421.12163 |
| format | Article |
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In addition, we aimed to gain insight into the mechanism involved in the immunomodulatory effect of the L. rhamnosus CRL1505 strain by evaluating the role of TLR2. Results showed that nasally given L. rhamnosus CRL1505 effectively regulates inflammation and hemostatic alterations during the pneumococcal infection. Immunobiotic treatment significantly reduced permeability of the bronchoalveolar–capillary barrier, and general cytotoxicity, decreasing lung tissue damage. The CRL1505 strain improved the production of TNF‐α, IFN‐γ, and IL‐10 after pneumococcal challenge. In addition, increased TM and TF expressions were found in lungs of L. rhamnosus CRL1505‐treated mice. Moreover, we demonstrated, for the first time, that the TLR2 signaling pathway has a role in the induction of IFN‐γ and IL‐10 and in the reduction of TF. The results also allow us to speculate that a PRR, other than TLR2, may mediate the immunobiotic activity of L. rhamnosus CRL1505 and could explain changes in TNF‐α and TM.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/1348-0421.12163</identifier><identifier>PMID: 24888715</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Animals ; Blood Coagulation ; Bronchoalveolar Lavage Fluid - cytology ; Cytokines - metabolism ; Disease Models, Animal ; hemostasis-inflammation ; Immunomodulation ; Lactobacillus rhamnosus ; Lactobacillus rhamnosus - immunology ; Lactobacillus rhamnosus CRL1505 ; Leukocyte Count ; lung injury ; Male ; Mice ; Pneumonia ; Pneumonia, Pneumococcal - blood ; Pneumonia, Pneumococcal - immunology ; Pneumonia, Pneumococcal - metabolism ; Rodents ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Toll-like receptor 2 ; Toll-Like Receptor 2 - metabolism</subject><ispartof>Microbiology and immunology, 2014-07, Vol.58 (7), p.416-426</ispartof><rights>2014 The Societies and Wiley Publishing Asia Pty Ltd</rights><rights>2014 The Societies and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6003-80d1cbcc052016983246138a80acfb6d2da681d1ea53f0da44a96fad248bc4133</citedby><cites>FETCH-LOGICAL-c6003-80d1cbcc052016983246138a80acfb6d2da681d1ea53f0da44a96fad248bc4133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1348-0421.12163$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1348-0421.12163$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24888715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zelaya, Hortensia</creatorcontrib><creatorcontrib>Villena, Julio</creatorcontrib><creatorcontrib>Lopez, Andres Gramajo</creatorcontrib><creatorcontrib>Alvarez, Susana</creatorcontrib><creatorcontrib>Agüero, Graciela</creatorcontrib><title>Modulation of the inflammation-coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: Role of Toll-like receptor 2</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>The present study evaluated the effect of nasally given Lactobacillus rhamnosus CRL1505 on the immunocoagulative response during pneumococcal infection in immunocompetent mice. 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The results also allow us to speculate that a PRR, other than TLR2, may mediate the immunobiotic activity of L. rhamnosus CRL1505 and could explain changes in TNF‐α and TM.</description><subject>Animals</subject><subject>Blood Coagulation</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>hemostasis-inflammation</subject><subject>Immunomodulation</subject><subject>Lactobacillus rhamnosus</subject><subject>Lactobacillus rhamnosus - immunology</subject><subject>Lactobacillus rhamnosus CRL1505</subject><subject>Leukocyte Count</subject><subject>lung injury</subject><subject>Male</subject><subject>Mice</subject><subject>Pneumonia</subject><subject>Pneumonia, Pneumococcal - blood</subject><subject>Pneumonia, Pneumococcal - immunology</subject><subject>Pneumonia, Pneumococcal - metabolism</subject><subject>Rodents</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Toll-like receptor 2</subject><subject>Toll-Like Receptor 2 - metabolism</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEUhS0EoqGwZocssWEzrd9x2KFAHyIpUlTE0vJ4PK1bjx3sGUH-Dr8UT14LNsUb29ffOda9B4C3GJ3hss4xZbJCjOAzTLCgz8DkWHkOJohKXnGB0Al4lfMDQmRKJHsJTgiTUk4xn4A_y9gMXvcuBhhb2N9b6ELrdddta5WJ-u7w7kJvkzbbczMkF-7gOtihiyYao_3-EpyG9Qa6rhtCrF3snYGLooq1Ns77IcN0r7sQcznNVwvMEf8IV9Hb8f_b6H3l3aOFyRq77mOC5DV40Wqf7Zv9fgq-X3y5nV9Vi2-X1_NPi8qUDmklUYNNbQziBGExk5QwganUEmnT1qIhjRYSN9hqTlvUaMb0TLS6KbOoDcOUnoIPO991ij8Hm3vVuWys9zrYOGSFyyQxIjNB_gNlU06RQKyg7_9BH-KQQmlkpCjHEjNeqPMdZVLMOdlWrZPrdNoojNSYtBpzVWOuapt0Ubzb-w51Z5sjf4i2AHwH_HLebp7yU8vr5cG42ulc7u3vo06nRyWmdMrVj5tLRfHFavX181xd0b-5wsL3</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Zelaya, Hortensia</creator><creator>Villena, Julio</creator><creator>Lopez, Andres Gramajo</creator><creator>Alvarez, Susana</creator><creator>Agüero, Graciela</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201407</creationdate><title>Modulation of the inflammation-coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: Role of Toll-like receptor 2</title><author>Zelaya, Hortensia ; Villena, Julio ; Lopez, Andres Gramajo ; Alvarez, Susana ; Agüero, Graciela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6003-80d1cbcc052016983246138a80acfb6d2da681d1ea53f0da44a96fad248bc4133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Blood Coagulation</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>hemostasis-inflammation</topic><topic>Immunomodulation</topic><topic>Lactobacillus rhamnosus</topic><topic>Lactobacillus rhamnosus - immunology</topic><topic>Lactobacillus rhamnosus CRL1505</topic><topic>Leukocyte Count</topic><topic>lung injury</topic><topic>Male</topic><topic>Mice</topic><topic>Pneumonia</topic><topic>Pneumonia, Pneumococcal - blood</topic><topic>Pneumonia, Pneumococcal - immunology</topic><topic>Pneumonia, Pneumococcal - metabolism</topic><topic>Rodents</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Toll-like receptor 2</topic><topic>Toll-Like Receptor 2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zelaya, Hortensia</creatorcontrib><creatorcontrib>Villena, Julio</creatorcontrib><creatorcontrib>Lopez, Andres Gramajo</creatorcontrib><creatorcontrib>Alvarez, Susana</creatorcontrib><creatorcontrib>Agüero, Graciela</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zelaya, Hortensia</au><au>Villena, Julio</au><au>Lopez, Andres Gramajo</au><au>Alvarez, Susana</au><au>Agüero, Graciela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of the inflammation-coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: Role of Toll-like receptor 2</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2014-07</date><risdate>2014</risdate><volume>58</volume><issue>7</issue><spage>416</spage><epage>426</epage><pages>416-426</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>The present study evaluated the effect of nasally given Lactobacillus rhamnosus CRL1505 on the immunocoagulative response during pneumococcal infection in immunocompetent mice. In addition, we aimed to gain insight into the mechanism involved in the immunomodulatory effect of the L. rhamnosus CRL1505 strain by evaluating the role of TLR2. Results showed that nasally given L. rhamnosus CRL1505 effectively regulates inflammation and hemostatic alterations during the pneumococcal infection. Immunobiotic treatment significantly reduced permeability of the bronchoalveolar–capillary barrier, and general cytotoxicity, decreasing lung tissue damage. The CRL1505 strain improved the production of TNF‐α, IFN‐γ, and IL‐10 after pneumococcal challenge. In addition, increased TM and TF expressions were found in lungs of L. rhamnosus CRL1505‐treated mice. Moreover, we demonstrated, for the first time, that the TLR2 signaling pathway has a role in the induction of IFN‐γ and IL‐10 and in the reduction of TF. The results also allow us to speculate that a PRR, other than TLR2, may mediate the immunobiotic activity of L. rhamnosus CRL1505 and could explain changes in TNF‐α and TM.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>24888715</pmid><doi>10.1111/1348-0421.12163</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Free Content; Open Access Titles of Japan; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animals Blood Coagulation Bronchoalveolar Lavage Fluid - cytology Cytokines - metabolism Disease Models, Animal hemostasis-inflammation Immunomodulation Lactobacillus rhamnosus Lactobacillus rhamnosus - immunology Lactobacillus rhamnosus CRL1505 Leukocyte Count lung injury Male Mice Pneumonia Pneumonia, Pneumococcal - blood Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - metabolism Rodents Streptococcus pneumoniae Streptococcus pneumoniae - immunology Toll-like receptor 2 Toll-Like Receptor 2 - metabolism |
| title | Modulation of the inflammation-coagulation interaction during pneumococcal pneumonia by immunobiotic Lactobacillus rhamnosus CRL1505: Role of Toll-like receptor 2 |
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