Plasticity of fimbrial genotype and serotype within populations of Bordetella pertussis: analysis by paired flow cytometry and genome sequencing

The fimbriae of Bordetella pertussis are required for colonization of the human respiratory tract. Two serologically distinct fimbrial subunits, Fim2 and Fim3, considered important vaccine components for many years, are included in the Sanofi Pasteur 5-component acellular pertussis vaccine, and the...

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Veröffentlicht in:	Microbiology (Society for General Microbiology) 2014-09, Vol.160 (Pt 9), p.2030-2044
Hauptverfasser:	Vaughan, Thomas E, Pratt, Catherine B, Sealey, Katie, Preston, Andrew, Fry, Norman K, Gorringe, Andrew R
Format:	Artikel
Sprache:	eng
Schlagworte:	Bordetella pertussis - genetics Bordetella pertussis - immunology Bordetella pertussis - isolation & purification DNA, Bacterial - chemistry DNA, Bacterial - genetics Fimbriae, Bacterial - genetics Fimbriae, Bacterial - immunology Flow Cytometry Genetic Variation Genome, Bacterial Genotype Humans Promoter Regions, Genetic Sequence Analysis, DNA Serogroup United Kingdom Whooping Cough - microbiology
Online-Zugang:	Volltext
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