Nitrofurantoin-mediated oxidative stress cytotoxicity in isolated rat hepatocytes

Freshly isolated rat hepatocytes were used to study the mechanism(s) of toxicity of the antimicrobial drug nitrofurantoin. This 5-nitrofuran derivative stimulated hepatocyte oxygen uptake in the presence of the mitochondrial respiration inhibitors KCN or antimycin A. This could indicate the formatio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1988-08, Vol.37 (16), p.3109-3117
Hauptverfasser:	Rossi, Luisa, Silva, Jose M., McGirr, Larry G., O'Brien, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Catalase - antagonists & inhibitors Cell Survival - drug effects Drug Synergism Drug toxicity and drugs side effects treatment Glutathione - analogs & derivatives Glutathione - metabolism Glutathione Disulfide Hydrogen Peroxide - metabolism Liver - cytology Liver - drug effects Medical sciences Nitrofurantoin - pharmacology Oxidation-Reduction Oxygen Consumption - drug effects Pharmacology. Drug treatments Rats Toxicity: digestive system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!