Enantioselective enzymatic sterol synthesis by ultrasonically stimulated bakers' yeast
We now wish to report that an "ultrasonically stimulated" suspension of bakers' yeast (Saccharomyces cerevisiae ) is an inexpensive, convenient, and direct source of a sterol cyclase which can be employed for the gram-scale enzymatic cyclization of squalene oxide and squalene-like sub...
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| Veröffentlicht in: | Journal of the American Chemical Society 1988, Vol.110 (2), p.604-606 |
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| container_end_page | 606 |
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| container_issue | 2 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 110 |
| creator | BUJONS, J GUAJARDO, R KYLER, K. S |
| description | We now wish to report that an "ultrasonically stimulated" suspension of bakers' yeast (Saccharomyces cerevisiae ) is an inexpensive, convenient, and direct source of a sterol cyclase which can be employed for the gram-scale enzymatic cyclization of squalene oxide and squalene-like substrates. Additionally, the enzymatic method is completely enantioselective as exemplified by a synthesis of lanosterol (2) and the cytotoxic agent, ganoderic acid Z (4a). |
| doi_str_mv | 10.1021/ja00210a052 |
| format | Article |
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S</creator><creatorcontrib>BUJONS, J ; GUAJARDO, R ; KYLER, K. S</creatorcontrib><description>We now wish to report that an "ultrasonically stimulated" suspension of bakers' yeast (Saccharomyces cerevisiae ) is an inexpensive, convenient, and direct source of a sterol cyclase which can be employed for the gram-scale enzymatic cyclization of squalene oxide and squalene-like substrates. Additionally, the enzymatic method is completely enantioselective as exemplified by a synthesis of lanosterol (2) and the cytotoxic agent, ganoderic acid Z (4a).</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/ja00210a052</identifier><identifier>CODEN: JACSAT</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; Fundamental and applied biological sciences. Psychology ; Methods. Procedures. 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S</creatorcontrib><title>Enantioselective enzymatic sterol synthesis by ultrasonically stimulated bakers' yeast</title><title>Journal of the American Chemical Society</title><description>We now wish to report that an "ultrasonically stimulated" suspension of bakers' yeast (Saccharomyces cerevisiae ) is an inexpensive, convenient, and direct source of a sterol cyclase which can be employed for the gram-scale enzymatic cyclization of squalene oxide and squalene-like substrates. Additionally, the enzymatic method is completely enantioselective as exemplified by a synthesis of lanosterol (2) and the cytotoxic agent, ganoderic acid Z (4a).</description><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Methods. Procedures. 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S</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>M7N</scope></search><sort><creationdate>1988</creationdate><title>Enantioselective enzymatic sterol synthesis by ultrasonically stimulated bakers' yeast</title><author>BUJONS, J ; GUAJARDO, R ; KYLER, K. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p213t-9410de70fbd770e555cfbfeb7c9e03179c300c31690a7c1d3297b086d7c1b6793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Methods. Procedures. Technologies</topic><topic>Saccharomyces cerevisiae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BUJONS, J</creatorcontrib><creatorcontrib>GUAJARDO, R</creatorcontrib><creatorcontrib>KYLER, K. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BUJONS, J</au><au>GUAJARDO, R</au><au>KYLER, K. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enantioselective enzymatic sterol synthesis by ultrasonically stimulated bakers' yeast</atitle><jtitle>Journal of the American Chemical Society</jtitle><date>1988</date><risdate>1988</risdate><volume>110</volume><issue>2</issue><spage>604</spage><epage>606</epage><pages>604-606</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><coden>JACSAT</coden><abstract>We now wish to report that an "ultrasonically stimulated" suspension of bakers' yeast (Saccharomyces cerevisiae ) is an inexpensive, convenient, and direct source of a sterol cyclase which can be employed for the gram-scale enzymatic cyclization of squalene oxide and squalene-like substrates. Additionally, the enzymatic method is completely enantioselective as exemplified by a synthesis of lanosterol (2) and the cytotoxic agent, ganoderic acid Z (4a).</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/ja00210a052</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-7863 |
| ispartof | Journal of the American Chemical Society, 1988, Vol.110 (2), p.604-606 |
| issn | 0002-7863 1520-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15597534 |
| source | ACS Publications |
| subjects | Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Saccharomyces cerevisiae |
| title | Enantioselective enzymatic sterol synthesis by ultrasonically stimulated bakers' yeast |
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