Structural Features of the Central Cannabinoid CB1 Receptor Involved in the Binding of the Specific CB1 Antagonist SR 141716A

The antagonist SR 141716A has a high specificity for the central CB1 cannabinoid receptor and negligeable affinity for the peripheral CB2 receptor, making it an excellent tool for probing receptor structure-activity relationships. From binding experiments with mutated CB1 and with chimeric CB1/CB2 r...

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Veröffentlicht in:	The Journal of biological chemistry 1996-03, Vol.271 (12), p.6941-6946
Hauptverfasser:	Shire, D, Calandra, B, Delpech, M, Dumont, X, Kaghad, M, Le Fur, G, Caput, D, Ferrara, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Molecular Sequence Data Mutagenesis, Site-Directed Piperidines - metabolism Protein Binding Protein Conformation Pyrazoles - metabolism Receptors, Cannabinoid Receptors, Drug - chemistry Receptors, Drug - genetics Receptors, Drug - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Rimonabant
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