Activity and distribution of protein kinase C in liver during the acute-phase response
Activity and subcellular distribution of protein kinase C were estimated in liver cytosol and membrane fractions of rats carrying a turpentine-induced inflammation. Protein kinase C activity increases significantly 8 h after treatment in the membrane fraction, with concurrent reduction in the cytoso...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1990-02, Vol.167 (1), p.345-352 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Piccoletti, Roberta Aletti, Maria Giovanna Bendinelli, Paola Arienti, Danilo Bernelli-Zazzera, Aldo |
| description | Activity and subcellular distribution of protein kinase C were estimated in liver cytosol and membrane fractions of rats carrying a turpentine-induced inflammation. Protein kinase C activity increases significantly 8 h after treatment in the membrane fraction, with concurrent reduction in the cytosol; 10 h after treatment the membrane-associated activity returns to normal, without concomitant recovery of that detected in the cytosol. The specific binding of phorbol dibutyrate to the liver membrane fraction increases but overall the effect is less evident and delayed in time. The changes are associated to alterations in the phosphorylation pattern of some liver proteins. Liver protein kinase C activity and intracellular distribution seem to be affected by a treatment which is known to induce an acute-phase response in the liver cells. |
| doi_str_mv | 10.1016/0006-291X(90)91771-J |
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Protein kinase C activity increases significantly 8 h after treatment in the membrane fraction, with concurrent reduction in the cytosol; 10 h after treatment the membrane-associated activity returns to normal, without concomitant recovery of that detected in the cytosol. The specific binding of phorbol dibutyrate to the liver membrane fraction increases but overall the effect is less evident and delayed in time. The changes are associated to alterations in the phosphorylation pattern of some liver proteins. 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Protein kinase C activity increases significantly 8 h after treatment in the membrane fraction, with concurrent reduction in the cytosol; 10 h after treatment the membrane-associated activity returns to normal, without concomitant recovery of that detected in the cytosol. The specific binding of phorbol dibutyrate to the liver membrane fraction increases but overall the effect is less evident and delayed in time. The changes are associated to alterations in the phosphorylation pattern of some liver proteins. 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Psychology</subject><subject>inflammation</subject><subject>Inflammation - enzymology</subject><subject>liver</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Membrane Proteins - metabolism</subject><subject>Phosphorylation</subject><subject>Protein Kinase C - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Transferases</subject><subject>Turpentine - toxicity</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EKtvCG4DkC6g9BDyJncSXStWKtlSVuADiZnnHE-o262xtZ6W-PV52VW6cZqT_m1-jj7F3ID6BgPazEKKtag2_TrU409B1UN28YAsQWlQ1CPmSLZ6R1-w4pXshAGSrj9hRydu-Vwv28wKz3_r8xG1w3PmUo1_N2U-BTwPfxCmTD_zBB5uIL3nZR7-lyN0cffjN8x1xi3OmanO3IyKlzRQSvWGvBjsmenuYJ-zH5Zfvy-vq9tvV1-XFbYUS-lx1qlaDXTWt1RKg7ppVhyigGRSoTtbYqaYh6VA5KW3fNzVCLzs3NIhuqKVqTtjHfW_59HGmlM3aJ6RxtIGmORlQSrdtXxdQ7kGMU0qRBrOJfm3jkwFhdjrNzpXZuTJamL86zU05e3_on1drcs9HB38l_3DIbUI7DtEG9Olfty66dasLd77nqMjYeoomoaeA5HwkzMZN_v-P_AGlsJE6</recordid><startdate>19900228</startdate><enddate>19900228</enddate><creator>Piccoletti, Roberta</creator><creator>Aletti, Maria Giovanna</creator><creator>Bendinelli, Paola</creator><creator>Arienti, Danilo</creator><creator>Bernelli-Zazzera, Aldo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope></search><sort><creationdate>19900228</creationdate><title>Activity and distribution of protein kinase C in liver during the acute-phase response</title><author>Piccoletti, Roberta ; Aletti, Maria Giovanna ; Bendinelli, Paola ; Arienti, Danilo ; Bernelli-Zazzera, Aldo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-7525fab36a9411273b7cc013f515742c7533e4dc5d44a8832c1847df3ccdf2453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acute-Phase Reaction - chemically induced</topic><topic>Acute-Phase Reaction - enzymology</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Fundamental and applied biological sciences. 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Protein kinase C activity increases significantly 8 h after treatment in the membrane fraction, with concurrent reduction in the cytosol; 10 h after treatment the membrane-associated activity returns to normal, without concomitant recovery of that detected in the cytosol. The specific binding of phorbol dibutyrate to the liver membrane fraction increases but overall the effect is less evident and delayed in time. The changes are associated to alterations in the phosphorylation pattern of some liver proteins. Liver protein kinase C activity and intracellular distribution seem to be affected by a treatment which is known to induce an acute-phase response in the liver cells.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2106885</pmid><doi>10.1016/0006-291X(90)91771-J</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute-Phase Reaction - chemically induced Acute-Phase Reaction - enzymology Analytical, structural and metabolic biochemistry Animals Autoradiography Biological and medical sciences Electrophoresis, Polyacrylamide Gel Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology inflammation Inflammation - enzymology liver Liver - enzymology Male Membrane Proteins - metabolism Phosphorylation Protein Kinase C - metabolism Rats Rats, Inbred Strains Transferases Turpentine - toxicity |
| title | Activity and distribution of protein kinase C in liver during the acute-phase response |
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