Trans-Cyclooctene Tag with Improved Properties for Tumor Pretargeting with the Diels–Alder Reaction

Radioimmunotherapy (RIT) of solid tumors is hampered by low tumor-to-nontumor (T/NT) ratios of the radiolabeled monoclonal antibodies resulting in low tumor doses in patients. Pretargeting technologies can improve the effectiveness of RIT in cancer therapy by increasing this ratio. We showed that a...

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Veröffentlicht in:	Molecular pharmaceutics 2014-09, Vol.11 (9), p.3090-3096
Hauptverfasser:	Rossin, Raffaella, van Duijnhoven, Sander M. J, Läppchen, Tilman, van den Bosch, Sandra M, Robillard, Marc S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Carcinoma - drug therapy Carcinoma - immunology Carcinoma - radiotherapy Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - radiotherapy Cycloaddition Reaction - methods Cyclooctanes - chemistry Cyclooctanes - immunology Cyclooctanes - therapeutic use Female Half-Life Humans Immunoconjugates - chemistry Immunoconjugates - immunology Immunoconjugates - pharmacology Mice Mice, Inbred BALB C Mice, Nude Radioimmunotherapy - methods Radiometry - methods Radiopharmaceuticals - chemistry Radiopharmaceuticals - immunology Radiopharmaceuticals - pharmacology Tissue Distribution - immunology
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