Interferon β-secreting mesenchymal stem cells combined with minocycline attenuate experimental autoimmune encephalomyelitis

Abstract We previously demonstrated that interferon β (IFN-β)-secreting mesenchymal stem cells (MSCs-IFN-β) strongly reduced the clinical severity of experimental autoimmune encephalomyelitis (EAE), compared with MSCs alone. Recently, minocycline ameliorates the clinical severity of multiple scleros...

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Veröffentlicht in:	Journal of neuroimmunology 2014-09, Vol.274 (1), p.20-27
Hauptverfasser:	Hou, Yun, Heon Ryu, Chung, Jun, Jin Ae, Kim, Seong Muk, Jeong, Chang Hyun, Jeun, Sin-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anti-Bacterial Agents - pharmacology Blood–spinal cord barrier disruption Cells, Cultured Combined Modality Therapy Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Experimental autoimmune encephalomyelitis Female Humans IFN-β-secreting mesenchymal stem cells Interferon-beta - immunology Interferon-beta - secretion Matrix Metalloproteinase 2 - immunology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - immunology Matrix Metalloproteinase 9 - metabolism Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - secretion Mice Mice, Inbred C57BL Minocycline Minocycline - pharmacology Multiple sclerosis Neurology Spinal Cord - immunology Spinal Cord - metabolism Th1 Cells - immunology Th2 Cells - immunology Tight junctions
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