Randomized controlled trial comparing the efficacy of mosapride plus omeprazole combination therapy to omeprazole monotherapy in gastroesophageal reflux disease

Objective We investigated whether the prokinetic activity of mosapride, a 5‐hydroxytryptamine 4 receptor agonist, in combination with proton pump inhibitor (PPI) would ameliorate symptoms of gastroesophageal reflux disease (GERD) in Japanese patients. Methods Patients who experienced reflux symptoms...

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Veröffentlicht in:	Journal of digestive diseases 2014-09, Vol.15 (9), p.469-476
Hauptverfasser:	Yamaji, Yutaka, Isomura, Yoshihiro, Yoshida, Shuntaro, Yamada, Atsuo, Hirata, Yoshihiro, Koike, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Benzamides - adverse effects Benzamides - therapeutic use Digestive system Drug Therapy, Combination Female Gastroesophageal reflux Gastroesophageal Reflux - drug therapy Gastroesophageal Reflux - physiopathology Gastrointestinal Agents - adverse effects Gastrointestinal Agents - therapeutic use gastrointestinal motility Gastrointestinal Motility - drug effects Humans Male Middle Aged Morpholines - adverse effects Morpholines - therapeutic use Omeprazole - adverse effects Omeprazole - therapeutic use prokinetic agent Prospective Studies proton pump inhibitors Proton Pump Inhibitors - adverse effects Proton Pump Inhibitors - therapeutic use quality of life questionnaire Severity of Illness Index Treatment Outcome
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