NGF level in the rat sciatic nerve is decreased after long-term consumption of ethanol
Long-Term effects of ethanol consumption on endogenous nerve growth factor (NGF) level were investigated in NGF-producing target organs and tissues of the peripheral nervous system. Rats were treated with ethanol (20% v/v) for 9 months, detoxified for an additional 2 weeks and kept without ethanol f...
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| Veröffentlicht in: | Neuroreport 1996-02, Vol.7 (3), p.777-780 |
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| creator | Hellweg, Rainer Baethge, Christopher Hartung, Heinz-Dieter Brückner, Martina K Arendt, Thomas |
| description | Long-Term effects of ethanol consumption on endogenous nerve growth factor (NGF) level were investigated in NGF-producing target organs and tissues of the peripheral nervous system. Rats were treated with ethanol (20% v/v) for 9 months, detoxified for an additional 2 weeks and kept without ethanol for an additional month prior to sacrifice. NGF level in the NGF-producing target tissues such as iris and subman-dibular gland and in the trigeminal ganglion and superior cervical ganglion, where NGF-responsive perikarya are located, did not differ significantly from corresponding controls. In contrast, NGF level in the sciatic nerve was significantly reduced by 54%. This indicates that long-term ethanol consumption affects retrograde axonal transport of the neurotrophic factor NGF, suggesting that NGF deficiency may be part of the pathophysiology of peripheral neuropathy due to chronic alcoholism. |
| doi_str_mv | 10.1097/00001756-199602290-00023 |
| format | Article |
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Rats were treated with ethanol (20% v/v) for 9 months, detoxified for an additional 2 weeks and kept without ethanol for an additional month prior to sacrifice. NGF level in the NGF-producing target tissues such as iris and subman-dibular gland and in the trigeminal ganglion and superior cervical ganglion, where NGF-responsive perikarya are located, did not differ significantly from corresponding controls. In contrast, NGF level in the sciatic nerve was significantly reduced by 54%. This indicates that long-term ethanol consumption affects retrograde axonal transport of the neurotrophic factor NGF, suggesting that NGF deficiency may be part of the pathophysiology of peripheral neuropathy due to chronic alcoholism.</description><subject>Alcoholism - metabolism</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Axonal Transport - drug effects</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Depression, Chemical</subject><subject>Ethanol - pharmacology</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sciatic Nerve - drug effects</subject><subject>Sciatic Nerve - metabolism</subject><subject>Superior Cervical Ganglion - drug effects</subject><subject>Superior Cervical Ganglion - metabolism</subject><subject>Toxicology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFO3DAQhi3Uii6UR0DyoeotxY7j2D5WqEAlBBeKuFkTZ8ymdeKtnYB4-xp2uzd8sTXz_TPSZ0IoZ984M-qMlcOVbCtuTMvq2rCqVGpxQFa8UaKSUj98ICtmpKka08pP5Cjn3wUxjOtDcqiVEKoRK3J_c3lBAz5hoMNE5zXSBDPNboB5cHTC9IR0yLRHlxAy9hT8jImGOD1W5TFSF6e8jJt5iBONnuK8himGz-Sjh5DxZHcfk18XP-7Or6rr28uf59-vK9dwKSquoDOm6xvVClSgufJKetTKu1p1nQbvHNZG-Y4D1KBk7RhzXIte-sZzJo7J1-3cTYp_F8yzHYfsMASYMC7ZcimNlG1bQL0FXYo5J_R2k4YR0ovlzL4qtf-V2r1S-6a0RE93O5ZuxH4f3Dks_S-7PmQHwSeY3JD3mGCqlpoXrNlizzEUc_lPWJ4x2TVCmNf2vQ8V_wC16o4a</recordid><startdate>19960229</startdate><enddate>19960229</enddate><creator>Hellweg, Rainer</creator><creator>Baethge, Christopher</creator><creator>Hartung, Heinz-Dieter</creator><creator>Brückner, Martina K</creator><creator>Arendt, Thomas</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19960229</creationdate><title>NGF level in the rat sciatic nerve is decreased after long-term consumption of ethanol</title><author>Hellweg, Rainer ; Baethge, Christopher ; Hartung, Heinz-Dieter ; Brückner, Martina K ; Arendt, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4153-17ab99bd4763e7a817f75fe87fc27bb8afcce297fb1aa2a752c00c183d5f4f103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alcoholism - metabolism</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Axonal Transport - drug effects</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Depression, Chemical</topic><topic>Ethanol - pharmacology</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Growth Factors - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sciatic Nerve - drug effects</topic><topic>Sciatic Nerve - metabolism</topic><topic>Superior Cervical Ganglion - drug effects</topic><topic>Superior Cervical Ganglion - metabolism</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hellweg, Rainer</creatorcontrib><creatorcontrib>Baethge, Christopher</creatorcontrib><creatorcontrib>Hartung, Heinz-Dieter</creatorcontrib><creatorcontrib>Brückner, Martina K</creatorcontrib><creatorcontrib>Arendt, Thomas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hellweg, Rainer</au><au>Baethge, Christopher</au><au>Hartung, Heinz-Dieter</au><au>Brückner, Martina K</au><au>Arendt, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NGF level in the rat sciatic nerve is decreased after long-term consumption of ethanol</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1996-02-29</date><risdate>1996</risdate><volume>7</volume><issue>3</issue><spage>777</spage><epage>780</epage><pages>777-780</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Long-Term effects of ethanol consumption on endogenous nerve growth factor (NGF) level were investigated in NGF-producing target organs and tissues of the peripheral nervous system. Rats were treated with ethanol (20% v/v) for 9 months, detoxified for an additional 2 weeks and kept without ethanol for an additional month prior to sacrifice. NGF level in the NGF-producing target tissues such as iris and subman-dibular gland and in the trigeminal ganglion and superior cervical ganglion, where NGF-responsive perikarya are located, did not differ significantly from corresponding controls. In contrast, NGF level in the sciatic nerve was significantly reduced by 54%. This indicates that long-term ethanol consumption affects retrograde axonal transport of the neurotrophic factor NGF, suggesting that NGF deficiency may be part of the pathophysiology of peripheral neuropathy due to chronic alcoholism.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8733743</pmid><doi>10.1097/00001756-199602290-00023</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroreport, 1996-02, Vol.7 (3), p.777-780 |
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| language | eng |
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| subjects | Alcoholism - metabolism Alcoholism and acute alcohol poisoning Animals Axonal Transport - drug effects Biological and medical sciences Central Nervous System Depressants - pharmacology Depression, Chemical Ethanol - pharmacology Immunoenzyme Techniques Male Medical sciences Nerve Growth Factors - metabolism Rats Rats, Sprague-Dawley Sciatic Nerve - drug effects Sciatic Nerve - metabolism Superior Cervical Ganglion - drug effects Superior Cervical Ganglion - metabolism Toxicology |
| title | NGF level in the rat sciatic nerve is decreased after long-term consumption of ethanol |
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