In vitro and in vivo characterization of newly developed iodinated 1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}piperazine derivatives in rats: Limited value as dopamine transporter SPECT ligands

A series of 1‐{2‐[bis(4‐fluorophenyl)methoxy]ethyl}piperazines (CYD1, 2, 3, 5) with a 4‐substituent incorporating a 1‐hydroxy‐3‐iodo‐2‐propenyl moiety, except CYD2 which lacks the hydroxy, was synthesized as potential in vivo imaging ligands for the dopamine transporter. For two of the piperazine de...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 1996-07, Vol.23 (3), p.201-207
Hauptverfasser:	Rijks, Leonie J.M., Booij, Jan, Doornbos, Tamme, Boer, Gerard J., Ronken, Eric, de Bruin, Kora, Jeroen Vermeulen, R., Janssen, Anton G.M., Van Royen, Eric A.
Format:	Artikel
Sprache:	eng
Schlagworte:	characterization for imaging dopamine reuptake sites piperazine analogues
Online-Zugang:	Volltext
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