An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys
Iron is increased in the substantia nigra of patients with Parkinson's disease, but the mechanism of its accumulation is unknown. We report the distribution of ferritin in the basal ganglia of hemiparkinsonian monkeys made by MPTP. We stereotactically injected MPTP unilaterally into the caudate...
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| Veröffentlicht in: | Brain research 1996-06, Vol.724 (1), p.125-128 |
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| creator | Goto, Keigo Mochizuki, Hideki Imai, Hisamasa Akiyama, Haruhiko Mizuno, Yoshikuni |
| description | Iron is increased in the substantia nigra of patients with Parkinson's disease, but the mechanism of its accumulation is unknown. We report the distribution of ferritin in the basal ganglia of hemiparkinsonian monkeys made by MPTP. We stereotactically injected MPTP unilaterally into the caudate nucleus of four monkeys, and the substantia nigra and the basal ganglia regions were stained for
l-ferritin by an immunohistochemical method. The ferritin immuno-staining was most intense in the pallidum and the pars reticulata of the substantia nigra on both injected and non-injected sides. No significant difference was noted in the immunostaining for ferritin in the pars compacta of the substantia nigra between the injected and the non-injected side. Iron was increased in the pars compacta of the substantia nigra of this hemiparkinsonian monkeys in our previous study. Normal ferritin immunostaining on the injected side would indicate that iron accumulation is not related to altered metabolism of t,-ferritin in this model. |
| doi_str_mv | 10.1016/0006-8993(96)00284-3 |
| format | Article |
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l-ferritin by an immunohistochemical method. The ferritin immuno-staining was most intense in the pallidum and the pars reticulata of the substantia nigra on both injected and non-injected sides. No significant difference was noted in the immunostaining for ferritin in the pars compacta of the substantia nigra between the injected and the non-injected side. Iron was increased in the pars compacta of the substantia nigra of this hemiparkinsonian monkeys in our previous study. Normal ferritin immunostaining on the injected side would indicate that iron accumulation is not related to altered metabolism of t,-ferritin in this model.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(96)00284-3</identifier><identifier>PMID: 8816266</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Biological and medical sciences ; Cell Count ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Ferritin ; Ferritins - analysis ; Immunohistochemistry ; Macaca fascicularis ; Male ; Medical sciences ; Mesencephalon - cytology ; Mesencephalon - physiopathology ; Microglia ; Microglia - metabolism ; MPTP ; Neurology ; Neurons - chemistry ; Neurons - cytology ; Neurons - enzymology ; Oxidative stress ; Oxidative Stress - physiology ; Parkinson Disease, Secondary - chemically induced ; Parkinson Disease, Secondary - metabolism ; Parkinson's disease ; Tyrosine 3-Monooxygenase - analysis</subject><ispartof>Brain research, 1996-06, Vol.724 (1), p.125-128</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-69b38ae836c7e84d0c45ab56526154d9ca7f5d7ae93d572c07b684fb5af9f39c3</citedby><cites>FETCH-LOGICAL-c483t-69b38ae836c7e84d0c45ab56526154d9ca7f5d7ae93d572c07b684fb5af9f39c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(96)00284-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3136477$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8816266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goto, Keigo</creatorcontrib><creatorcontrib>Mochizuki, Hideki</creatorcontrib><creatorcontrib>Imai, Hisamasa</creatorcontrib><creatorcontrib>Akiyama, Haruhiko</creatorcontrib><creatorcontrib>Mizuno, Yoshikuni</creatorcontrib><title>An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Iron is increased in the substantia nigra of patients with Parkinson's disease, but the mechanism of its accumulation is unknown. We report the distribution of ferritin in the basal ganglia of hemiparkinsonian monkeys made by MPTP. We stereotactically injected MPTP unilaterally into the caudate nucleus of four monkeys, and the substantia nigra and the basal ganglia regions were stained for
l-ferritin by an immunohistochemical method. The ferritin immuno-staining was most intense in the pallidum and the pars reticulata of the substantia nigra on both injected and non-injected sides. No significant difference was noted in the immunostaining for ferritin in the pars compacta of the substantia nigra between the injected and the non-injected side. Iron was increased in the pars compacta of the substantia nigra of this hemiparkinsonian monkeys in our previous study. Normal ferritin immunostaining on the injected side would indicate that iron accumulation is not related to altered metabolism of t,-ferritin in this model.</description><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Ferritin</subject><subject>Ferritins - analysis</subject><subject>Immunohistochemistry</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mesencephalon - cytology</subject><subject>Mesencephalon - physiopathology</subject><subject>Microglia</subject><subject>Microglia - metabolism</subject><subject>MPTP</subject><subject>Neurology</subject><subject>Neurons - chemistry</subject><subject>Neurons - cytology</subject><subject>Neurons - enzymology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>Parkinson Disease, Secondary - metabolism</subject><subject>Parkinson's disease</subject><subject>Tyrosine 3-Monooxygenase - analysis</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM-L1TAQx4Mo63P1P1DoQWQXXjRp0jS5CMviL1hxD-s5pMmUxm2TZ9IKPfqfm_Ie7-hpZpjPfBk-CL2m5D0lVHwghAgslWJXSlwTUkuO2RO0o7Ktsag5eYp2Z-Q5epHzrzIypsgFupCSilqIHfp7Eyo_TUuIePB5jnaAyVszVnle3FrFvuohJT_7goWK4gnmYR0xx4cBQmnovt6zvcAzzMkMq0vxsCbvfIDq6vv9w_019sEtFly1BR9MevQhx-BNqKYYHmHNL9Gz3owZXp3qJfr5-dPD7Vd89-PLt9ubO2y5ZDMWqmPSgGTCtiC5I5Y3pmtEUwvacKesafvGtQYUc01bW9J2QvK-a0yveqYsu0TvjrmHFH8vkGc9-WxhHE2AuGRNm0aRWpEC8iNoU8w5Qa8PyU8mrZoSvZnXm1a9adVqG4p5zcrZm1P-0k3gzkcn1WX_9rQ3uQjukwnW5zPGKBO8bQv28YhBcfHHQ9LZegjFoE9gZ-2i__8f_wDD1qAW</recordid><startdate>19960610</startdate><enddate>19960610</enddate><creator>Goto, Keigo</creator><creator>Mochizuki, Hideki</creator><creator>Imai, Hisamasa</creator><creator>Akiyama, Haruhiko</creator><creator>Mizuno, Yoshikuni</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19960610</creationdate><title>An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys</title><author>Goto, Keigo ; Mochizuki, Hideki ; Imai, Hisamasa ; Akiyama, Haruhiko ; Mizuno, Yoshikuni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-69b38ae836c7e84d0c45ab56526154d9ca7f5d7ae93d572c07b684fb5af9f39c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Ferritin</topic><topic>Ferritins - analysis</topic><topic>Immunohistochemistry</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mesencephalon - cytology</topic><topic>Mesencephalon - physiopathology</topic><topic>Microglia</topic><topic>Microglia - metabolism</topic><topic>MPTP</topic><topic>Neurology</topic><topic>Neurons - chemistry</topic><topic>Neurons - cytology</topic><topic>Neurons - enzymology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>Parkinson Disease, Secondary - metabolism</topic><topic>Parkinson's disease</topic><topic>Tyrosine 3-Monooxygenase - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goto, Keigo</creatorcontrib><creatorcontrib>Mochizuki, Hideki</creatorcontrib><creatorcontrib>Imai, Hisamasa</creatorcontrib><creatorcontrib>Akiyama, Haruhiko</creatorcontrib><creatorcontrib>Mizuno, Yoshikuni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goto, Keigo</au><au>Mochizuki, Hideki</au><au>Imai, Hisamasa</au><au>Akiyama, Haruhiko</au><au>Mizuno, Yoshikuni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1996-06-10</date><risdate>1996</risdate><volume>724</volume><issue>1</issue><spage>125</spage><epage>128</epage><pages>125-128</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Iron is increased in the substantia nigra of patients with Parkinson's disease, but the mechanism of its accumulation is unknown. We report the distribution of ferritin in the basal ganglia of hemiparkinsonian monkeys made by MPTP. We stereotactically injected MPTP unilaterally into the caudate nucleus of four monkeys, and the substantia nigra and the basal ganglia regions were stained for
l-ferritin by an immunohistochemical method. The ferritin immuno-staining was most intense in the pallidum and the pars reticulata of the substantia nigra on both injected and non-injected sides. No significant difference was noted in the immunostaining for ferritin in the pars compacta of the substantia nigra between the injected and the non-injected side. Iron was increased in the pars compacta of the substantia nigra of this hemiparkinsonian monkeys in our previous study. Normal ferritin immunostaining on the injected side would indicate that iron accumulation is not related to altered metabolism of t,-ferritin in this model.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8816266</pmid><doi>10.1016/0006-8993(96)00284-3</doi><tpages>4</tpages></addata></record> |
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| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Biological and medical sciences Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Ferritin Ferritins - analysis Immunohistochemistry Macaca fascicularis Male Medical sciences Mesencephalon - cytology Mesencephalon - physiopathology Microglia Microglia - metabolism MPTP Neurology Neurons - chemistry Neurons - cytology Neurons - enzymology Oxidative stress Oxidative Stress - physiology Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - metabolism Parkinson's disease Tyrosine 3-Monooxygenase - analysis |
| title | An immuno-histochemical study of ferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys |
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