HLA antigens in tardive dyskinesia
Fifty-three male, Caucasian, neuroleptic-treated patients with chronic schizophrenia were examined for the presence of tardive dyskinesia (TD) and were tissue typed. The group with TD ( n = 25) was compared to the group without TD ( n = 28). HLA-DR4 was more prevalent in the group with TD than in th...
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| Veröffentlicht in: | Journal of neuroimmunology 1990-02, Vol.26 (2), p.179-181 |
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| container_end_page | 181 |
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| container_issue | 2 |
| container_start_page | 179 |
| container_title | Journal of neuroimmunology |
| container_volume | 26 |
| creator | Steven Metzer, W. Newton, J.E.O. Steele, Russell W. Claybrook, Marsha Paige, Stephen R. McMillan, D.E. Hays, Sarah |
| description | Fifty-three male, Caucasian, neuroleptic-treated patients with chronic schizophrenia were examined for the presence of tardive dyskinesia (TD) and were tissue typed. The group with TD (
n = 25) was compared to the group without TD (
n = 28). HLA-DR4 was more prevalent in the group with TD than in the group without TD, with a relative risk of 3.04 for TD with HLA-DR4 present, although this finding is not statistically significant when corrected for the number of nonparametric comparisons. Other investigations reported an association between HLA-B44 and TD, or between HLA-B44 and neuroleptic-induced parkinsonism. Potential explanations relating the findings of these investigations are discussed. |
| doi_str_mv | 10.1016/0165-5728(90)90089-6 |
| format | Article |
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n = 25) was compared to the group without TD (
n = 28). HLA-DR4 was more prevalent in the group with TD than in the group without TD, with a relative risk of 3.04 for TD with HLA-DR4 present, although this finding is not statistically significant when corrected for the number of nonparametric comparisons. Other investigations reported an association between HLA-B44 and TD, or between HLA-B44 and neuroleptic-induced parkinsonism. Potential explanations relating the findings of these investigations are discussed.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/0165-5728(90)90089-6</identifier><identifier>PMID: 2298884</identifier><identifier>CODEN: JNRIDW</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Biological and medical sciences ; Dyskinesia, Drug-Induced - immunology ; HLA Antigens - analysis ; HLA-DR4 Antigen - analysis ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology</subject><ispartof>Journal of neuroimmunology, 1990-02, Vol.26 (2), p.179-181</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e93fbc3713428e3bd14dc94a107375df5717996d12ebd2a897a244e9e9bf000e3</citedby><cites>FETCH-LOGICAL-c417t-e93fbc3713428e3bd14dc94a107375df5717996d12ebd2a897a244e9e9bf000e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-5728(90)90089-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6694399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2298884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steven Metzer, W.</creatorcontrib><creatorcontrib>Newton, J.E.O.</creatorcontrib><creatorcontrib>Steele, Russell W.</creatorcontrib><creatorcontrib>Claybrook, Marsha</creatorcontrib><creatorcontrib>Paige, Stephen R.</creatorcontrib><creatorcontrib>McMillan, D.E.</creatorcontrib><creatorcontrib>Hays, Sarah</creatorcontrib><title>HLA antigens in tardive dyskinesia</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Fifty-three male, Caucasian, neuroleptic-treated patients with chronic schizophrenia were examined for the presence of tardive dyskinesia (TD) and were tissue typed. The group with TD (
n = 25) was compared to the group without TD (
n = 28). HLA-DR4 was more prevalent in the group with TD than in the group without TD, with a relative risk of 3.04 for TD with HLA-DR4 present, although this finding is not statistically significant when corrected for the number of nonparametric comparisons. Other investigations reported an association between HLA-B44 and TD, or between HLA-B44 and neuroleptic-induced parkinsonism. Potential explanations relating the findings of these investigations are discussed.</description><subject>Biological and medical sciences</subject><subject>Dyskinesia, Drug-Induced - immunology</subject><subject>HLA Antigens - analysis</subject><subject>HLA-DR4 Antigen - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLAzEQhYMotVb_gcIiInpYTbLZTeYiFFErFLzoOWSTWYlutzXZFvrv3bVLjx6GOcz3HvMeIeeM3jHKivtu8jSXXN0AvQVKFaTFARkzJXmqBGeHZLxHjslJjF-UsjwTMCIjzkEpJcbkcjafJqZp_Sc2MfFN0prg_AYTt43fvsHozSk5qkwd8WzYE_Lx_PT-OEvnby-vj9N5agWTbYqQVaXNJMsEV5iVjglnQRhGZSZzV-WSSYDCMY6l40aBNFwIBISyopRiNiHXO99VWP6sMbZ64aPFujYNLtdRszwHymXRgWIH2rCMMWClV8EvTNhqRnVfje5z6z63Bqr_qtG97GLwX5cLdHvR0EV3vxruJlpTV8E01sc9VhQgMoAOe9hh2HWx8Rh0tB4bi84HtK12S___H7_As303</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>Steven Metzer, W.</creator><creator>Newton, J.E.O.</creator><creator>Steele, Russell W.</creator><creator>Claybrook, Marsha</creator><creator>Paige, Stephen R.</creator><creator>McMillan, D.E.</creator><creator>Hays, Sarah</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19900201</creationdate><title>HLA antigens in tardive dyskinesia</title><author>Steven Metzer, W. ; Newton, J.E.O. ; Steele, Russell W. ; Claybrook, Marsha ; Paige, Stephen R. ; McMillan, D.E. ; Hays, Sarah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e93fbc3713428e3bd14dc94a107375df5717996d12ebd2a897a244e9e9bf000e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Biological and medical sciences</topic><topic>Dyskinesia, Drug-Induced - immunology</topic><topic>HLA Antigens - analysis</topic><topic>HLA-DR4 Antigen - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steven Metzer, W.</creatorcontrib><creatorcontrib>Newton, J.E.O.</creatorcontrib><creatorcontrib>Steele, Russell W.</creatorcontrib><creatorcontrib>Claybrook, Marsha</creatorcontrib><creatorcontrib>Paige, Stephen R.</creatorcontrib><creatorcontrib>McMillan, D.E.</creatorcontrib><creatorcontrib>Hays, Sarah</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steven Metzer, W.</au><au>Newton, J.E.O.</au><au>Steele, Russell W.</au><au>Claybrook, Marsha</au><au>Paige, Stephen R.</au><au>McMillan, D.E.</au><au>Hays, Sarah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA antigens in tardive dyskinesia</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1990-02-01</date><risdate>1990</risdate><volume>26</volume><issue>2</issue><spage>179</spage><epage>181</epage><pages>179-181</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><coden>JNRIDW</coden><abstract>Fifty-three male, Caucasian, neuroleptic-treated patients with chronic schizophrenia were examined for the presence of tardive dyskinesia (TD) and were tissue typed. The group with TD (
n = 25) was compared to the group without TD (
n = 28). HLA-DR4 was more prevalent in the group with TD than in the group without TD, with a relative risk of 3.04 for TD with HLA-DR4 present, although this finding is not statistically significant when corrected for the number of nonparametric comparisons. Other investigations reported an association between HLA-B44 and TD, or between HLA-B44 and neuroleptic-induced parkinsonism. Potential explanations relating the findings of these investigations are discussed.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2298884</pmid><doi>10.1016/0165-5728(90)90089-6</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 1990-02, Vol.26 (2), p.179-181 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Dyskinesia, Drug-Induced - immunology HLA Antigens - analysis HLA-DR4 Antigen - analysis Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Nervous system as a whole Neurology |
| title | HLA antigens in tardive dyskinesia |
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