The influence of obesity on short- and long-term outcomes after laparoscopic surgery for colon cancer: A case-matched study of 152 patients
Background Despite the increasing prevalence of obesity and colonic diseases, the impact of obesity on short-term and oncologic outcomes of laparoscopic colorectal surgery still remains unclear. Study design Seventy-six consecutive obese patients with body mass index (BMI) ≥30 kg/m2 who underwent la...
Gespeichert in:
| Veröffentlicht in: | Surgery 2014-09, Vol.156 (3), p.661-668 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 668 |
|---|---|
| container_issue | 3 |
| container_start_page | 661 |
| container_title | Surgery |
| container_volume | 156 |
| creator | Makino, Tomoki, MD, PhD, FACS Trencheva, Koiana, BSN, MS Shukla, Parul J., MD, FACS Rubino, Francesco, MD, FACS Zhuo, Changhua, MD, FACS Pavoor, Raghava S., MD, FACS Milsom, Jeffrey W., MD, FACS |
| description | Background Despite the increasing prevalence of obesity and colonic diseases, the impact of obesity on short-term and oncologic outcomes of laparoscopic colorectal surgery still remains unclear. Study design Seventy-six consecutive obese patients with body mass index (BMI) ≥30 kg/m2 who underwent laparoscopic colectomy were matched with 76 nonobese patients with BMI |
| doi_str_mv | 10.1016/j.surg.2014.03.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1559012025</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0039606014001160</els_id><sourcerecordid>1559012025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-5529ce066a15ba31e2f41bd3158c17652299df8edcbd7e16aaa9314528b3bbcc3</originalsourceid><addsrcrecordid>eNp9UsuO1DAQjBCIHRZ-gAPykUtCtx0nE4SQVite0kocWM6WY3d2PCTxYDsr5Rv4aRzNwoEDJ9tSVbmrqoviJUKFgM2bYxWXcFdxwLoCUQEXj4odSsHLVjT4uNgBiK5soIGL4lmMRwDoatw_LS543dVtU8td8ev2QMzNw7jQbIj5gfmeoksr8zOLBx9SyfRs2ejnuzJRmJhfkvETRaaH_GajPungo_EnZ9g2D4WVDT4w4zOHGZ1lw1t2lW-RykkncyDLYlrsuv2GkrOTTo7mFJ8XTwY9RnrxcF4W3z9-uL3-XN58_fTl-uqmNLJuUykl7wxB02iUvRZIfKixtwLl3mDbSM67zg57sqa3LWGjte4E1pLve9H3xojL4vVZ9xT8z4ViUpOLhsZRz-SXqFDKDpADlxnKz1CTPcZAgzoFN-mwKgS1laCOajOtthIUCJVLyKRXD_pLP5H9S_mTega8OwMou7x3FFQ0bsvfukAmKevd__Xf_0M3o5ud0eMPWike_RLmnJ9CFbkC9W1bg20LsAZAbED8BurSrsU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1559012025</pqid></control><display><type>article</type><title>The influence of obesity on short- and long-term outcomes after laparoscopic surgery for colon cancer: A case-matched study of 152 patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Makino, Tomoki, MD, PhD, FACS ; Trencheva, Koiana, BSN, MS ; Shukla, Parul J., MD, FACS ; Rubino, Francesco, MD, FACS ; Zhuo, Changhua, MD, FACS ; Pavoor, Raghava S., MD, FACS ; Milsom, Jeffrey W., MD, FACS</creator><creatorcontrib>Makino, Tomoki, MD, PhD, FACS ; Trencheva, Koiana, BSN, MS ; Shukla, Parul J., MD, FACS ; Rubino, Francesco, MD, FACS ; Zhuo, Changhua, MD, FACS ; Pavoor, Raghava S., MD, FACS ; Milsom, Jeffrey W., MD, FACS</creatorcontrib><description>Background Despite the increasing prevalence of obesity and colonic diseases, the impact of obesity on short-term and oncologic outcomes of laparoscopic colorectal surgery still remains unclear. Study design Seventy-six consecutive obese patients with body mass index (BMI) ≥30 kg/m2 who underwent laparoscopic colectomy were matched with 76 nonobese patients with BMI <30 kg/m2 . Perioperative parameters and oncologic outcomes were analyzed in the two groups. Results Obesity was associated with greater operative time (obese vs nonobese, 182 ± 59 vs 157 ± 55 min, P = .0084) and multivariate analysis identified BMI (hazard ratio 2.11, 95% confidence interval 0.64–3.56, P = .0049) as an independent predicting factor for operative time together with cancer location (hazard ratio 28.6, 95% confidence interval 14.62–42.51, P < .0001). Obesity had no adverse influence on overall morbidity (25 vs 21%, P = .563), however, or postoperative duration of stay (median 6.0 vs 5.5 days, P = .22). Furthermore, the rate of conversion to open procedure was similar between the two groups (9 vs 9%, P > .99). Regarding oncologic outcomes, there was no statistical difference in overall and disease-free survival between the two groups (5-year overall survival rate 86 vs 89%, P = .72, 5-year disease survival rate 70 vs 77%, P = .70). Conclusion Laparoscopic colonic resection, when performed for selected patients, appears to be a safe and reasonable option in obese patients with colon cancer resulting in similar short-term and oncologic outcomes as nonobese patients.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2014.03.023</identifier><identifier>PMID: 24947645</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Body Mass Index ; Case-Control Studies ; Colectomy ; Colonic Neoplasms - complications ; Colonic Neoplasms - surgery ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Laparoscopy ; Male ; Middle Aged ; Obesity - complications ; Obesity - pathology ; Operative Time ; Surgery ; Time Factors ; Treatment Outcome</subject><ispartof>Surgery, 2014-09, Vol.156 (3), p.661-668</ispartof><rights>Mosby, Inc.</rights><rights>2014 Mosby, Inc.</rights><rights>Copyright © 2014 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-5529ce066a15ba31e2f41bd3158c17652299df8edcbd7e16aaa9314528b3bbcc3</citedby><cites>FETCH-LOGICAL-c547t-5529ce066a15ba31e2f41bd3158c17652299df8edcbd7e16aaa9314528b3bbcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.surg.2014.03.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24947645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Makino, Tomoki, MD, PhD, FACS</creatorcontrib><creatorcontrib>Trencheva, Koiana, BSN, MS</creatorcontrib><creatorcontrib>Shukla, Parul J., MD, FACS</creatorcontrib><creatorcontrib>Rubino, Francesco, MD, FACS</creatorcontrib><creatorcontrib>Zhuo, Changhua, MD, FACS</creatorcontrib><creatorcontrib>Pavoor, Raghava S., MD, FACS</creatorcontrib><creatorcontrib>Milsom, Jeffrey W., MD, FACS</creatorcontrib><title>The influence of obesity on short- and long-term outcomes after laparoscopic surgery for colon cancer: A case-matched study of 152 patients</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background Despite the increasing prevalence of obesity and colonic diseases, the impact of obesity on short-term and oncologic outcomes of laparoscopic colorectal surgery still remains unclear. Study design Seventy-six consecutive obese patients with body mass index (BMI) ≥30 kg/m2 who underwent laparoscopic colectomy were matched with 76 nonobese patients with BMI <30 kg/m2 . Perioperative parameters and oncologic outcomes were analyzed in the two groups. Results Obesity was associated with greater operative time (obese vs nonobese, 182 ± 59 vs 157 ± 55 min, P = .0084) and multivariate analysis identified BMI (hazard ratio 2.11, 95% confidence interval 0.64–3.56, P = .0049) as an independent predicting factor for operative time together with cancer location (hazard ratio 28.6, 95% confidence interval 14.62–42.51, P < .0001). Obesity had no adverse influence on overall morbidity (25 vs 21%, P = .563), however, or postoperative duration of stay (median 6.0 vs 5.5 days, P = .22). Furthermore, the rate of conversion to open procedure was similar between the two groups (9 vs 9%, P > .99). Regarding oncologic outcomes, there was no statistical difference in overall and disease-free survival between the two groups (5-year overall survival rate 86 vs 89%, P = .72, 5-year disease survival rate 70 vs 77%, P = .70). Conclusion Laparoscopic colonic resection, when performed for selected patients, appears to be a safe and reasonable option in obese patients with colon cancer resulting in similar short-term and oncologic outcomes as nonobese patients.</description><subject>Aged</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Colectomy</subject><subject>Colonic Neoplasms - complications</subject><subject>Colonic Neoplasms - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Laparoscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Obesity - pathology</subject><subject>Operative Time</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UsuO1DAQjBCIHRZ-gAPykUtCtx0nE4SQVite0kocWM6WY3d2PCTxYDsr5Rv4aRzNwoEDJ9tSVbmrqoviJUKFgM2bYxWXcFdxwLoCUQEXj4odSsHLVjT4uNgBiK5soIGL4lmMRwDoatw_LS543dVtU8td8ev2QMzNw7jQbIj5gfmeoksr8zOLBx9SyfRs2ejnuzJRmJhfkvETRaaH_GajPungo_EnZ9g2D4WVDT4w4zOHGZ1lw1t2lW-RykkncyDLYlrsuv2GkrOTTo7mFJ8XTwY9RnrxcF4W3z9-uL3-XN58_fTl-uqmNLJuUykl7wxB02iUvRZIfKixtwLl3mDbSM67zg57sqa3LWGjte4E1pLve9H3xojL4vVZ9xT8z4ViUpOLhsZRz-SXqFDKDpADlxnKz1CTPcZAgzoFN-mwKgS1laCOajOtthIUCJVLyKRXD_pLP5H9S_mTega8OwMou7x3FFQ0bsvfukAmKevd__Xf_0M3o5ud0eMPWike_RLmnJ9CFbkC9W1bg20LsAZAbED8BurSrsU</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Makino, Tomoki, MD, PhD, FACS</creator><creator>Trencheva, Koiana, BSN, MS</creator><creator>Shukla, Parul J., MD, FACS</creator><creator>Rubino, Francesco, MD, FACS</creator><creator>Zhuo, Changhua, MD, FACS</creator><creator>Pavoor, Raghava S., MD, FACS</creator><creator>Milsom, Jeffrey W., MD, FACS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>The influence of obesity on short- and long-term outcomes after laparoscopic surgery for colon cancer: A case-matched study of 152 patients</title><author>Makino, Tomoki, MD, PhD, FACS ; Trencheva, Koiana, BSN, MS ; Shukla, Parul J., MD, FACS ; Rubino, Francesco, MD, FACS ; Zhuo, Changhua, MD, FACS ; Pavoor, Raghava S., MD, FACS ; Milsom, Jeffrey W., MD, FACS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-5529ce066a15ba31e2f41bd3158c17652299df8edcbd7e16aaa9314528b3bbcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Colectomy</topic><topic>Colonic Neoplasms - complications</topic><topic>Colonic Neoplasms - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Laparoscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Obesity - pathology</topic><topic>Operative Time</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Makino, Tomoki, MD, PhD, FACS</creatorcontrib><creatorcontrib>Trencheva, Koiana, BSN, MS</creatorcontrib><creatorcontrib>Shukla, Parul J., MD, FACS</creatorcontrib><creatorcontrib>Rubino, Francesco, MD, FACS</creatorcontrib><creatorcontrib>Zhuo, Changhua, MD, FACS</creatorcontrib><creatorcontrib>Pavoor, Raghava S., MD, FACS</creatorcontrib><creatorcontrib>Milsom, Jeffrey W., MD, FACS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Makino, Tomoki, MD, PhD, FACS</au><au>Trencheva, Koiana, BSN, MS</au><au>Shukla, Parul J., MD, FACS</au><au>Rubino, Francesco, MD, FACS</au><au>Zhuo, Changhua, MD, FACS</au><au>Pavoor, Raghava S., MD, FACS</au><au>Milsom, Jeffrey W., MD, FACS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of obesity on short- and long-term outcomes after laparoscopic surgery for colon cancer: A case-matched study of 152 patients</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>156</volume><issue>3</issue><spage>661</spage><epage>668</epage><pages>661-668</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><abstract>Background Despite the increasing prevalence of obesity and colonic diseases, the impact of obesity on short-term and oncologic outcomes of laparoscopic colorectal surgery still remains unclear. Study design Seventy-six consecutive obese patients with body mass index (BMI) ≥30 kg/m2 who underwent laparoscopic colectomy were matched with 76 nonobese patients with BMI <30 kg/m2 . Perioperative parameters and oncologic outcomes were analyzed in the two groups. Results Obesity was associated with greater operative time (obese vs nonobese, 182 ± 59 vs 157 ± 55 min, P = .0084) and multivariate analysis identified BMI (hazard ratio 2.11, 95% confidence interval 0.64–3.56, P = .0049) as an independent predicting factor for operative time together with cancer location (hazard ratio 28.6, 95% confidence interval 14.62–42.51, P < .0001). Obesity had no adverse influence on overall morbidity (25 vs 21%, P = .563), however, or postoperative duration of stay (median 6.0 vs 5.5 days, P = .22). Furthermore, the rate of conversion to open procedure was similar between the two groups (9 vs 9%, P > .99). Regarding oncologic outcomes, there was no statistical difference in overall and disease-free survival between the two groups (5-year overall survival rate 86 vs 89%, P = .72, 5-year disease survival rate 70 vs 77%, P = .70). Conclusion Laparoscopic colonic resection, when performed for selected patients, appears to be a safe and reasonable option in obese patients with colon cancer resulting in similar short-term and oncologic outcomes as nonobese patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24947645</pmid><doi>10.1016/j.surg.2014.03.023</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-6060 |
| ispartof | Surgery, 2014-09, Vol.156 (3), p.661-668 |
| issn | 0039-6060 1532-7361 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1559012025 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Body Mass Index Case-Control Studies Colectomy Colonic Neoplasms - complications Colonic Neoplasms - surgery Disease-Free Survival Female Humans Kaplan-Meier Estimate Laparoscopy Male Middle Aged Obesity - complications Obesity - pathology Operative Time Surgery Time Factors Treatment Outcome |
| title | The influence of obesity on short- and long-term outcomes after laparoscopic surgery for colon cancer: A case-matched study of 152 patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T02%3A35%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20influence%20of%20obesity%20on%20short-%20and%20long-term%20outcomes%20after%20laparoscopic%20surgery%20for%20colon%20cancer:%20A%20case-matched%20study%20of%20152%20patients&rft.jtitle=Surgery&rft.au=Makino,%20Tomoki,%20MD,%20PhD,%20FACS&rft.date=2014-09-01&rft.volume=156&rft.issue=3&rft.spage=661&rft.epage=668&rft.pages=661-668&rft.issn=0039-6060&rft.eissn=1532-7361&rft_id=info:doi/10.1016/j.surg.2014.03.023&rft_dat=%3Cproquest_cross%3E1559012025%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1559012025&rft_id=info:pmid/24947645&rft_els_id=1_s2_0_S0039606014001160&rfr_iscdi=true |