α-Heteroarylation of Ketones via the Umpolung Reaction of N-Alkoxyenamine
A new method has been developed for the umpolung α-heteroarylation of ketones via an N-alkoxyenamine. The treatment of ketones with tris(heteroaryl)aluminum reagents in the presence of isoxazolidine gave the corresponding α-heteroarylated ketones in moderate to good yields.
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2014/09/01, Vol.62(9), pp.927-932 |
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| container_issue | 9 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 62 |
| creator | Miyoshi, Tetsuya Takeda, Norihiko Fukami, Masaki Sato, Shohei Ueda, Masafumi Miyata, Okiko |
| description | A new method has been developed for the umpolung α-heteroarylation of ketones via an N-alkoxyenamine. The treatment of ketones with tris(heteroaryl)aluminum reagents in the presence of isoxazolidine gave the corresponding α-heteroarylated ketones in moderate to good yields. |
| doi_str_mv | 10.1248/cpb.c14-00404 |
| format | Article |
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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 2014/09/01, Vol.62(9), pp.927-932 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | aluminum heteroarylation Heterocyclic Compounds - chemistry Hydrocarbons - chemistry Ketones - chemistry Magnetic Resonance Spectroscopy N-alkoxyenamine Spectrometry, Mass, Electrospray Ionization Spectroscopy, Fourier Transform Infrared umpolung |
| title | α-Heteroarylation of Ketones via the Umpolung Reaction of N-Alkoxyenamine |
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