Evaluation of antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus and Escherichia coli from bovine mastitis
[Display omitted] Bovine mastitis is a serious veterinary disease that causes great loss to the dairy industry worldwide. It is a major infectious disease and is difficult to manage and control. Furthermore, emerging multidrug resistant bacteria that cause mastitis have complicated such management....
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| Veröffentlicht in: | International journal of pharmaceutics 2014-10, Vol.473 (1-2), p.20-29 |
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| container_title | International journal of pharmaceutics |
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| creator | Cardozo, Viviane F. Lancheros, Cesar A.C. Narciso, Adélia M. Valereto, Elaine C.S. Kobayashi, Renata K.T. Seabra, Amedea B. Nakazato, Gerson |
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Bovine mastitis is a serious veterinary disease that causes great loss to the dairy industry worldwide. It is a major infectious disease and is difficult to manage and control. Furthermore, emerging multidrug resistant bacteria that cause mastitis have complicated such management. The free radical nitric oxide (NO) is a potent antimicrobial agent. Thus, the aims of this study were to prepare and evaluate the antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus (MBSA) and Escherichia coli (MBEC), which were isolated from bovine mastitis. Fifteen MBSA isolates and fifteen MBEC were collected from subclinical and clinical bovine mastitis. Biocompatible polymeric particles composed of alginate/chitosan or chitosan/sodium tripolyphosphate (TPP) were prepared and used to encapsulate mercaptosuccinic acid (MSA), which is a thiol-containing molecule. Nitrosation of thiol groups of MSA-containing particles formed S-nitroso-MSA particles, which are NO donors. The NO release kinetics from the S-nitroso-MSA particles showed sustained and controlled NO release over several hours. The antibacterial activity of NO-releasing particles was evaluated by incubating the particles with an MBSA multi-resistant strain, which is responsible for bovine mastitis. The minimum inhibitory concentration for S-nitroso-MSA-alginate/chitosan particles against MBSA ranged from 125μg/mL to 250μg/mL. The results indicate that NO-releasing polymeric particles are an interesting approach to combating bacteria resistance in bovine mastitis treatment and prevention. |
| doi_str_mv | 10.1016/j.ijpharm.2014.06.051 |
| format | Article |
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Bovine mastitis is a serious veterinary disease that causes great loss to the dairy industry worldwide. It is a major infectious disease and is difficult to manage and control. Furthermore, emerging multidrug resistant bacteria that cause mastitis have complicated such management. The free radical nitric oxide (NO) is a potent antimicrobial agent. Thus, the aims of this study were to prepare and evaluate the antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus (MBSA) and Escherichia coli (MBEC), which were isolated from bovine mastitis. Fifteen MBSA isolates and fifteen MBEC were collected from subclinical and clinical bovine mastitis. Biocompatible polymeric particles composed of alginate/chitosan or chitosan/sodium tripolyphosphate (TPP) were prepared and used to encapsulate mercaptosuccinic acid (MSA), which is a thiol-containing molecule. Nitrosation of thiol groups of MSA-containing particles formed S-nitroso-MSA particles, which are NO donors. The NO release kinetics from the S-nitroso-MSA particles showed sustained and controlled NO release over several hours. The antibacterial activity of NO-releasing particles was evaluated by incubating the particles with an MBSA multi-resistant strain, which is responsible for bovine mastitis. The minimum inhibitory concentration for S-nitroso-MSA-alginate/chitosan particles against MBSA ranged from 125μg/mL to 250μg/mL. The results indicate that NO-releasing polymeric particles are an interesting approach to combating bacteria resistance in bovine mastitis treatment and prevention.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2014.06.051</identifier><identifier>PMID: 24979535</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alginates - chemistry ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Bovine mastitis ; Cattle ; Cell Line, Tumor ; Cell Survival - drug effects ; Chitosan - chemistry ; E.coli ; Escherichia coli - drug effects ; Escherichia coli - growth & development ; Female ; Humans ; Mastitis, Bovine - microbiology ; Microbial Sensitivity Tests ; Nitric oxide ; Nitric Oxide - chemistry ; Polymeric particles ; Polyphosphates - chemistry ; S.aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - growth & development ; Thiomalates - chemistry ; Thiomalates - pharmacology</subject><ispartof>International journal of pharmaceutics, 2014-10, Vol.473 (1-2), p.20-29</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-309c30959f2de41dcef957d6688cd1b6343bb485fbd67c5ca1158fdd0f42c78f3</citedby><cites>FETCH-LOGICAL-c365t-309c30959f2de41dcef957d6688cd1b6343bb485fbd67c5ca1158fdd0f42c78f3</cites><orcidid>0000-0002-8696-6388</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517314004803$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24979535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cardozo, Viviane F.</creatorcontrib><creatorcontrib>Lancheros, Cesar A.C.</creatorcontrib><creatorcontrib>Narciso, Adélia M.</creatorcontrib><creatorcontrib>Valereto, Elaine C.S.</creatorcontrib><creatorcontrib>Kobayashi, Renata K.T.</creatorcontrib><creatorcontrib>Seabra, Amedea B.</creatorcontrib><creatorcontrib>Nakazato, Gerson</creatorcontrib><title>Evaluation of antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus and Escherichia coli from bovine mastitis</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Bovine mastitis is a serious veterinary disease that causes great loss to the dairy industry worldwide. It is a major infectious disease and is difficult to manage and control. Furthermore, emerging multidrug resistant bacteria that cause mastitis have complicated such management. The free radical nitric oxide (NO) is a potent antimicrobial agent. Thus, the aims of this study were to prepare and evaluate the antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus (MBSA) and Escherichia coli (MBEC), which were isolated from bovine mastitis. Fifteen MBSA isolates and fifteen MBEC were collected from subclinical and clinical bovine mastitis. Biocompatible polymeric particles composed of alginate/chitosan or chitosan/sodium tripolyphosphate (TPP) were prepared and used to encapsulate mercaptosuccinic acid (MSA), which is a thiol-containing molecule. Nitrosation of thiol groups of MSA-containing particles formed S-nitroso-MSA particles, which are NO donors. The NO release kinetics from the S-nitroso-MSA particles showed sustained and controlled NO release over several hours. The antibacterial activity of NO-releasing particles was evaluated by incubating the particles with an MBSA multi-resistant strain, which is responsible for bovine mastitis. The minimum inhibitory concentration for S-nitroso-MSA-alginate/chitosan particles against MBSA ranged from 125μg/mL to 250μg/mL. The results indicate that NO-releasing polymeric particles are an interesting approach to combating bacteria resistance in bovine mastitis treatment and prevention.</description><subject>Alginates - chemistry</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Bovine mastitis</subject><subject>Cattle</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Chitosan - chemistry</subject><subject>E.coli</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - growth & development</subject><subject>Female</subject><subject>Humans</subject><subject>Mastitis, Bovine - microbiology</subject><subject>Microbial Sensitivity Tests</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - chemistry</subject><subject>Polymeric particles</subject><subject>Polyphosphates - chemistry</subject><subject>S.aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - growth & development</subject><subject>Thiomalates - chemistry</subject><subject>Thiomalates - pharmacology</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO1DAMhiMEYoeFRwDlyKUlaZq0PSG0GmCllTgA5yhN3B2P0qYk6Yh5FZ6WVjNw3YNly_5_W9ZHyFvOSs64-nAs8TgfTBzLivG6ZKpkkj8jO942ohB1o56THRNNW0jeiBvyKqUjY0xVXLwkN1XdNZ0Uckf-7E_GLyZjmGgYqJky9sZmiGg8XQs8YT5vkwlzREvDb3RQRPBgEk6PdA7-PMI2mU3MaD0kah4NTinT79nMh7MPNli7rO0lwpYmR_fJHjbTAQ21wSMdYhhpH044AR1NypgxvSYvBuMTvLnmW_Lz8_7H3dfi4duX-7tPD4UVSuZCsM6uIbuhclBzZ2HoZOOUalvreK9ELfq-buXQO9VYaQ3nsh2cY0Nd2aYdxC15f9k7x_BrgZT1iMmC92aCsCTNpewY6zirVqm8SG0MKUUY9BxxNPGsOdMbFn3UVyx6w6KZ0iuW1ffuemLpR3D_Xf84rIKPFwGsj54Qok4WYbLgMILN2gV84sRf-bGmOg</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Cardozo, Viviane F.</creator><creator>Lancheros, Cesar A.C.</creator><creator>Narciso, Adélia M.</creator><creator>Valereto, Elaine C.S.</creator><creator>Kobayashi, Renata K.T.</creator><creator>Seabra, Amedea B.</creator><creator>Nakazato, Gerson</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8696-6388</orcidid></search><sort><creationdate>20141001</creationdate><title>Evaluation of antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus and Escherichia coli from bovine mastitis</title><author>Cardozo, Viviane F. ; Lancheros, Cesar A.C. ; Narciso, Adélia M. ; Valereto, Elaine C.S. ; Kobayashi, Renata K.T. ; Seabra, Amedea B. ; Nakazato, Gerson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-309c30959f2de41dcef957d6688cd1b6343bb485fbd67c5ca1158fdd0f42c78f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alginates - chemistry</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Bovine mastitis</topic><topic>Cattle</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Chitosan - chemistry</topic><topic>E.coli</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - growth & development</topic><topic>Female</topic><topic>Humans</topic><topic>Mastitis, Bovine - microbiology</topic><topic>Microbial Sensitivity Tests</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - chemistry</topic><topic>Polymeric particles</topic><topic>Polyphosphates - chemistry</topic><topic>S.aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - growth & development</topic><topic>Thiomalates - chemistry</topic><topic>Thiomalates - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardozo, Viviane F.</creatorcontrib><creatorcontrib>Lancheros, Cesar A.C.</creatorcontrib><creatorcontrib>Narciso, Adélia M.</creatorcontrib><creatorcontrib>Valereto, Elaine C.S.</creatorcontrib><creatorcontrib>Kobayashi, Renata K.T.</creatorcontrib><creatorcontrib>Seabra, Amedea B.</creatorcontrib><creatorcontrib>Nakazato, Gerson</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardozo, Viviane F.</au><au>Lancheros, Cesar A.C.</au><au>Narciso, Adélia M.</au><au>Valereto, Elaine C.S.</au><au>Kobayashi, Renata K.T.</au><au>Seabra, Amedea B.</au><au>Nakazato, Gerson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus and Escherichia coli from bovine mastitis</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>473</volume><issue>1-2</issue><spage>20</spage><epage>29</epage><pages>20-29</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Bovine mastitis is a serious veterinary disease that causes great loss to the dairy industry worldwide. It is a major infectious disease and is difficult to manage and control. Furthermore, emerging multidrug resistant bacteria that cause mastitis have complicated such management. The free radical nitric oxide (NO) is a potent antimicrobial agent. Thus, the aims of this study were to prepare and evaluate the antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus (MBSA) and Escherichia coli (MBEC), which were isolated from bovine mastitis. Fifteen MBSA isolates and fifteen MBEC were collected from subclinical and clinical bovine mastitis. Biocompatible polymeric particles composed of alginate/chitosan or chitosan/sodium tripolyphosphate (TPP) were prepared and used to encapsulate mercaptosuccinic acid (MSA), which is a thiol-containing molecule. Nitrosation of thiol groups of MSA-containing particles formed S-nitroso-MSA particles, which are NO donors. The NO release kinetics from the S-nitroso-MSA particles showed sustained and controlled NO release over several hours. The antibacterial activity of NO-releasing particles was evaluated by incubating the particles with an MBSA multi-resistant strain, which is responsible for bovine mastitis. The minimum inhibitory concentration for S-nitroso-MSA-alginate/chitosan particles against MBSA ranged from 125μg/mL to 250μg/mL. The results indicate that NO-releasing polymeric particles are an interesting approach to combating bacteria resistance in bovine mastitis treatment and prevention.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24979535</pmid><doi>10.1016/j.ijpharm.2014.06.051</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8696-6388</orcidid></addata></record> |
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| subjects | Alginates - chemistry Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Bovine mastitis Cattle Cell Line, Tumor Cell Survival - drug effects Chitosan - chemistry E.coli Escherichia coli - drug effects Escherichia coli - growth & development Female Humans Mastitis, Bovine - microbiology Microbial Sensitivity Tests Nitric oxide Nitric Oxide - chemistry Polymeric particles Polyphosphates - chemistry S.aureus Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Thiomalates - chemistry Thiomalates - pharmacology |
| title | Evaluation of antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus and Escherichia coli from bovine mastitis |
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