Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells

Highlights • HS-527 inhibits the angiogenesis of pancreatic cancer. • HS-527 induces the apoptosis of pancreatic cancer. • HS-527 inhibit PI3K/Akt signaling pathway.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-10, Vol.353 (1), p.68-77
Hauptverfasser:	Ryu, Ye-Lim, Jung, Kyung Hee, Son, Mi Kwon, Yan, Hong Hua, Kim, Soo Jung, Shin, Sanghye, Hong, Sungwoo, Hong, Soon-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Aminopyridines - toxicity Angiogenesis Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - toxicity Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chromatography Dose-Response Relationship, Drug Hematology, Oncology and Palliative Medicine HS-527 Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - enzymology Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kinases Mice Mitochondria Molecular Targeted Therapy Neovascularization, Physiologic - drug effects Pancreas Pancreatic cancer Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - pathology Phosphatidylinositol 3-Kinase - antagonists & inhibitors Phosphatidylinositol 3-Kinase - metabolism PI3K Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - toxicity Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Studies Sulfonamides - pharmacology Sulfonamides - toxicity Time Factors Vascular Endothelial Growth Factor A - metabolism
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Beschreibung
Zusammenfassung:	Highlights • HS-527 inhibits the angiogenesis of pancreatic cancer. • HS-527 induces the apoptosis of pancreatic cancer. • HS-527 inhibit PI3K/Akt signaling pathway.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.07.001