Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders Gender and diurnal urine regulation
Aim We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2. Methods Fifteen young women in mid‐follicular phase and 22 young men (20–33 years) were included. All participants underwent a 24‐h circadian in...
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| Veröffentlicht in: | Acta Physiologica 2014-09, Vol.212 (1), p.97-105 |
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| creator | Graugaard-Jensen, C. Hvistendahl, G. M. Frøkiær, J. Bie, P. Djurhuus, J. C. |
| description | Aim
We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2.
Methods
Fifteen young women in mid‐follicular phase and 22 young men (20–33 years) were included. All participants underwent a 24‐h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin‐2 and prostaglandin E2.
Results
Plasma vasopressin expressed a diurnal rhythm with a night‐time increase in both genders (P |
| doi_str_mv | 10.1111/apha.12337 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1559008623</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3418525951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4287-3c31ad81711b9495d98b6bf00c3ffb17d7612f386904acbbcaab60ff0b0e10753</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi0EotXSCw-ALHFBSFk8dhI7x6WCLVIFFWpB4mLZzqS4ZJ1gJ233ypOTzbZ74IAPHkvzzT-e-Ql5CWwJ03ln-p9mCVwI-YQcg8xVBhLKp4c3U0fkJKUbxhhwEDnnz8kRz6uyUKU6Jn-uog8mbqnrgsMwRDP4LtC6w0RDN1C8d-2Y_C22Wxp315TsW5M2ht6a1PURU_JhSVc0DWO9pRaHO8RArzHUGBNdz5GaUNPajzGYlo5TR5zErsd2bvaCPGtMm_DkIS7I1ccPl6dn2fmX9afT1Xnmcq5kJpwAU6tpOrBVXhV1pWxpG8acaBoLspYl8EaosmK5cdY6Y2zJmoZZhsBkIRbkzV63j93vEdOgNz45bFsTsBuThqKoGFPltMsFef0PetPNn58plVccYEe93VMudilFbHQf_WZapgamd-bonTl6NmeCXz1IjnaD9QF9tGICYA_c-Ra3_5HSq4uz1aNotq_xacD7Q42Jv3QphSz0989rfSG-ri_5t_f6h_gLgX-qlw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1558492113</pqid></control><display><type>article</type><title>Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders Gender and diurnal urine regulation</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Graugaard-Jensen, C. ; Hvistendahl, G. M. ; Frøkiær, J. ; Bie, P. ; Djurhuus, J. C.</creator><creatorcontrib>Graugaard-Jensen, C. ; Hvistendahl, G. M. ; Frøkiær, J. ; Bie, P. ; Djurhuus, J. C.</creatorcontrib><description>Aim
We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2.
Methods
Fifteen young women in mid‐follicular phase and 22 young men (20–33 years) were included. All participants underwent a 24‐h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin‐2 and prostaglandin E2.
Results
Plasma vasopressin expressed a diurnal rhythm with a night‐time increase in both genders (P < 0.001). The ratio between mean daytime and mean night‐time was 1.57 [95% CI: 1.33–1.84] P < 0.001 in men and 1.35 [95% CI: 1.11–1.64] P = 0.002 in women. P‐vasopressin was higher in males during the night (P < 0.05). There was no difference in diuresis (P = 0.43), urine osmolality (P = 0.12) or aquaporin‐2 excretion (P = 0.80) between genders. We found a trend towards a higher reabsorption of free water in males (P = 0.07). The excretion of prostaglandin E2 was higher in males (P < 0.001). There was no diurnal rhythm in p‐oxytocin (P = 0.37) and no correlation to diuresis, urine osmolality or aquaporin‐2 excretions.
Conclusion
Similar urinary flows and osmolalities are associated with levels of plasma vasopressin and renal PGE2, which are higher in males than in females. Oxytocin does not seem to play a role in the diurnal urine formation, whereas prostaglandin E2 could represent a mediator of the gender difference, not only as a mediator of the vasopressin response, but also as an independent factor. These findings need further elucidation.</description><identifier>ISSN: 1748-1708</identifier><identifier>EISSN: 1748-1716</identifier><identifier>DOI: 10.1111/apha.12337</identifier><identifier>PMID: 24965868</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aquaporin 2 - urine ; arginine vasopressin ; Arginine Vasopressin - blood ; Circadian Rhythm - physiology ; Dinoprostone - urine ; diuresis ; diurnal rhythm ; Female ; Humans ; Male ; oxytocin ; Oxytocin - blood ; prostaglandin E2 ; Radioimmunoassay ; Sex Characteristics ; Urination - physiology ; Young Adult</subject><ispartof>Acta Physiologica, 2014-09, Vol.212 (1), p.97-105</ispartof><rights>2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd</rights><rights>2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4287-3c31ad81711b9495d98b6bf00c3ffb17d7612f386904acbbcaab60ff0b0e10753</citedby><cites>FETCH-LOGICAL-c4287-3c31ad81711b9495d98b6bf00c3ffb17d7612f386904acbbcaab60ff0b0e10753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapha.12337$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapha.12337$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24965868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graugaard-Jensen, C.</creatorcontrib><creatorcontrib>Hvistendahl, G. M.</creatorcontrib><creatorcontrib>Frøkiær, J.</creatorcontrib><creatorcontrib>Bie, P.</creatorcontrib><creatorcontrib>Djurhuus, J. C.</creatorcontrib><title>Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders Gender and diurnal urine regulation</title><title>Acta Physiologica</title><addtitle>Acta Physiol</addtitle><description>Aim
We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2.
Methods
Fifteen young women in mid‐follicular phase and 22 young men (20–33 years) were included. All participants underwent a 24‐h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin‐2 and prostaglandin E2.
Results
Plasma vasopressin expressed a diurnal rhythm with a night‐time increase in both genders (P < 0.001). The ratio between mean daytime and mean night‐time was 1.57 [95% CI: 1.33–1.84] P < 0.001 in men and 1.35 [95% CI: 1.11–1.64] P = 0.002 in women. P‐vasopressin was higher in males during the night (P < 0.05). There was no difference in diuresis (P = 0.43), urine osmolality (P = 0.12) or aquaporin‐2 excretion (P = 0.80) between genders. We found a trend towards a higher reabsorption of free water in males (P = 0.07). The excretion of prostaglandin E2 was higher in males (P < 0.001). There was no diurnal rhythm in p‐oxytocin (P = 0.37) and no correlation to diuresis, urine osmolality or aquaporin‐2 excretions.
Conclusion
Similar urinary flows and osmolalities are associated with levels of plasma vasopressin and renal PGE2, which are higher in males than in females. Oxytocin does not seem to play a role in the diurnal urine formation, whereas prostaglandin E2 could represent a mediator of the gender difference, not only as a mediator of the vasopressin response, but also as an independent factor. These findings need further elucidation.</description><subject>Adult</subject><subject>Aquaporin 2 - urine</subject><subject>arginine vasopressin</subject><subject>Arginine Vasopressin - blood</subject><subject>Circadian Rhythm - physiology</subject><subject>Dinoprostone - urine</subject><subject>diuresis</subject><subject>diurnal rhythm</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>oxytocin</subject><subject>Oxytocin - blood</subject><subject>prostaglandin E2</subject><subject>Radioimmunoassay</subject><subject>Sex Characteristics</subject><subject>Urination - physiology</subject><subject>Young Adult</subject><issn>1748-1708</issn><issn>1748-1716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EotXSCw-ALHFBSFk8dhI7x6WCLVIFFWpB4mLZzqS4ZJ1gJ233ypOTzbZ74IAPHkvzzT-e-Ql5CWwJ03ln-p9mCVwI-YQcg8xVBhLKp4c3U0fkJKUbxhhwEDnnz8kRz6uyUKU6Jn-uog8mbqnrgsMwRDP4LtC6w0RDN1C8d-2Y_C22Wxp315TsW5M2ht6a1PURU_JhSVc0DWO9pRaHO8RArzHUGBNdz5GaUNPajzGYlo5TR5zErsd2bvaCPGtMm_DkIS7I1ccPl6dn2fmX9afT1Xnmcq5kJpwAU6tpOrBVXhV1pWxpG8acaBoLspYl8EaosmK5cdY6Y2zJmoZZhsBkIRbkzV63j93vEdOgNz45bFsTsBuThqKoGFPltMsFef0PetPNn58plVccYEe93VMudilFbHQf_WZapgamd-bonTl6NmeCXz1IjnaD9QF9tGICYA_c-Ra3_5HSq4uz1aNotq_xacD7Q42Jv3QphSz0989rfSG-ri_5t_f6h_gLgX-qlw</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Graugaard-Jensen, C.</creator><creator>Hvistendahl, G. M.</creator><creator>Frøkiær, J.</creator><creator>Bie, P.</creator><creator>Djurhuus, J. C.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders Gender and diurnal urine regulation</title><author>Graugaard-Jensen, C. ; Hvistendahl, G. M. ; Frøkiær, J. ; Bie, P. ; Djurhuus, J. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4287-3c31ad81711b9495d98b6bf00c3ffb17d7612f386904acbbcaab60ff0b0e10753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aquaporin 2 - urine</topic><topic>arginine vasopressin</topic><topic>Arginine Vasopressin - blood</topic><topic>Circadian Rhythm - physiology</topic><topic>Dinoprostone - urine</topic><topic>diuresis</topic><topic>diurnal rhythm</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>oxytocin</topic><topic>Oxytocin - blood</topic><topic>prostaglandin E2</topic><topic>Radioimmunoassay</topic><topic>Sex Characteristics</topic><topic>Urination - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graugaard-Jensen, C.</creatorcontrib><creatorcontrib>Hvistendahl, G. M.</creatorcontrib><creatorcontrib>Frøkiær, J.</creatorcontrib><creatorcontrib>Bie, P.</creatorcontrib><creatorcontrib>Djurhuus, J. C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Physiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graugaard-Jensen, C.</au><au>Hvistendahl, G. M.</au><au>Frøkiær, J.</au><au>Bie, P.</au><au>Djurhuus, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders Gender and diurnal urine regulation</atitle><jtitle>Acta Physiologica</jtitle><addtitle>Acta Physiol</addtitle><date>2014-09</date><risdate>2014</risdate><volume>212</volume><issue>1</issue><spage>97</spage><epage>105</epage><pages>97-105</pages><issn>1748-1708</issn><eissn>1748-1716</eissn><abstract>Aim
We investigated the influence of gender on the diurnal regulation of urine production with special focus on vasopressin, oxytocin and prostaglandin E2.
Methods
Fifteen young women in mid‐follicular phase and 22 young men (20–33 years) were included. All participants underwent a 24‐h circadian inpatient study under standardized conditions for measurements of plasma vasopressin, oxytocin, sodium and osmolality. Urine was fractionally collected for measurements of electrolytes, aquaporin‐2 and prostaglandin E2.
Results
Plasma vasopressin expressed a diurnal rhythm with a night‐time increase in both genders (P < 0.001). The ratio between mean daytime and mean night‐time was 1.57 [95% CI: 1.33–1.84] P < 0.001 in men and 1.35 [95% CI: 1.11–1.64] P = 0.002 in women. P‐vasopressin was higher in males during the night (P < 0.05). There was no difference in diuresis (P = 0.43), urine osmolality (P = 0.12) or aquaporin‐2 excretion (P = 0.80) between genders. We found a trend towards a higher reabsorption of free water in males (P = 0.07). The excretion of prostaglandin E2 was higher in males (P < 0.001). There was no diurnal rhythm in p‐oxytocin (P = 0.37) and no correlation to diuresis, urine osmolality or aquaporin‐2 excretions.
Conclusion
Similar urinary flows and osmolalities are associated with levels of plasma vasopressin and renal PGE2, which are higher in males than in females. Oxytocin does not seem to play a role in the diurnal urine formation, whereas prostaglandin E2 could represent a mediator of the gender difference, not only as a mediator of the vasopressin response, but also as an independent factor. These findings need further elucidation.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24965868</pmid><doi>10.1111/apha.12337</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aquaporin 2 - urine arginine vasopressin Arginine Vasopressin - blood Circadian Rhythm - physiology Dinoprostone - urine diuresis diurnal rhythm Female Humans Male oxytocin Oxytocin - blood prostaglandin E2 Radioimmunoassay Sex Characteristics Urination - physiology Young Adult |
| title | Urinary concentration does not exclusively rely on plasma vasopressin. A study between genders Gender and diurnal urine regulation |
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