Dimorphic changes of some features of loving relationships during long-term use of antidepressants in depressed outpatients
Abstract The present study aimed at investigating the possible changes of some features of loving relationships during long-term treatment of depression with both selective serotonin reuptake inhibitors (SSRIs) and tricyclics (TCAs), by means of a specifically designed test, the so-called “Sex, Atta...
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| Veröffentlicht in: | Journal of affective disorders 2014-09, Vol.166, p.151-155 |
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| container_title | Journal of affective disorders |
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| creator | Marazziti, Donatella Akiskal, Hagop S Udo, Mieko Picchetti, Michela Baroni, Stefano Massimetti, Gabriele Albanese, Francesco Dell׳Osso, Liliana |
| description | Abstract The present study aimed at investigating the possible changes of some features of loving relationships during long-term treatment of depression with both selective serotonin reuptake inhibitors (SSRIs) and tricyclics (TCAs), by means of a specifically designed test, the so-called “Sex, Attachment, Love” (SALT) questionnaire. The sample was composed by 192 outpatients (123 women and 69 men, mean age±SD: 41.2±10.2 years), suffering from mild or moderate depression, according to DSM-IV-TR criteria, that were selected if they were treated with one antidepressant only for at least six months and were involved in a loving relationship. The results showed that SSRIs had a significant impact on the feelings of love and attachment towards the partner especially in men, while women taking TCAs complained of more sexual side effects than men. These data were supported also by the detection of a significant interaction between drug and sex on the “Love” and “Sex” domains. The present findings, while demonstrating a dimorphic effect of antidepressants on some component of loving relationships, need to be deepened in future studies. |
| doi_str_mv | 10.1016/j.jad.2014.04.043 |
| format | Article |
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The sample was composed by 192 outpatients (123 women and 69 men, mean age±SD: 41.2±10.2 years), suffering from mild or moderate depression, according to DSM-IV-TR criteria, that were selected if they were treated with one antidepressant only for at least six months and were involved in a loving relationship. The results showed that SSRIs had a significant impact on the feelings of love and attachment towards the partner especially in men, while women taking TCAs complained of more sexual side effects than men. These data were supported also by the detection of a significant interaction between drug and sex on the “Love” and “Sex” domains. The present findings, while demonstrating a dimorphic effect of antidepressants on some component of loving relationships, need to be deepened in future studies.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2014.04.043</identifier><identifier>PMID: 25012424</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antidepressant drugs ; Antidepressants ; Antidepressive Agents, Tricyclic - administration & dosage ; Antidepressive Agents, Tricyclic - adverse effects ; Attachment ; Biological and medical sciences ; Coitus ; Depression ; Depression - drug therapy ; Depression - epidemiology ; Depression - psychology ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - psychology ; Drug Administration Schedule ; Emotional blunting ; Family Characteristics ; Female ; Gender ; Heterosexuality - psychology ; Homosexuality - psychology ; Humans ; Italy - epidemiology ; Love ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Mood disorders ; Neuropharmacology ; Object Attachment ; Outpatients ; Pharmacology. Drug treatments ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Romantic relationships ; Self Report ; Serotonin reuptake inhibitors ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - adverse effects ; Severity of Illness Index ; Sex Factors ; Side effects</subject><ispartof>Journal of affective disorders, 2014-09, Vol.166, p.151-155</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-e0e27316c021fa2cb9cd9ef502d3959532ffdb56b9def927775b42f8a1cbb4a33</citedby><cites>FETCH-LOGICAL-c504t-e0e27316c021fa2cb9cd9ef502d3959532ffdb56b9def927775b42f8a1cbb4a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2014.04.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,31005,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28605710$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25012424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marazziti, Donatella</creatorcontrib><creatorcontrib>Akiskal, Hagop S</creatorcontrib><creatorcontrib>Udo, Mieko</creatorcontrib><creatorcontrib>Picchetti, Michela</creatorcontrib><creatorcontrib>Baroni, Stefano</creatorcontrib><creatorcontrib>Massimetti, Gabriele</creatorcontrib><creatorcontrib>Albanese, Francesco</creatorcontrib><creatorcontrib>Dell׳Osso, Liliana</creatorcontrib><title>Dimorphic changes of some features of loving relationships during long-term use of antidepressants in depressed outpatients</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract The present study aimed at investigating the possible changes of some features of loving relationships during long-term treatment of depression with both selective serotonin reuptake inhibitors (SSRIs) and tricyclics (TCAs), by means of a specifically designed test, the so-called “Sex, Attachment, Love” (SALT) questionnaire. The sample was composed by 192 outpatients (123 women and 69 men, mean age±SD: 41.2±10.2 years), suffering from mild or moderate depression, according to DSM-IV-TR criteria, that were selected if they were treated with one antidepressant only for at least six months and were involved in a loving relationship. The results showed that SSRIs had a significant impact on the feelings of love and attachment towards the partner especially in men, while women taking TCAs complained of more sexual side effects than men. These data were supported also by the detection of a significant interaction between drug and sex on the “Love” and “Sex” domains. The present findings, while demonstrating a dimorphic effect of antidepressants on some component of loving relationships, need to be deepened in future studies.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antidepressant drugs</subject><subject>Antidepressants</subject><subject>Antidepressive Agents, Tricyclic - administration & dosage</subject><subject>Antidepressive Agents, Tricyclic - adverse effects</subject><subject>Attachment</subject><subject>Biological and medical sciences</subject><subject>Coitus</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Depression - epidemiology</subject><subject>Depression - psychology</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Drug Administration Schedule</subject><subject>Emotional blunting</subject><subject>Family Characteristics</subject><subject>Female</subject><subject>Gender</subject><subject>Heterosexuality - psychology</subject><subject>Homosexuality - psychology</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Love</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Neuropharmacology</subject><subject>Object Attachment</subject><subject>Outpatients</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatry</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Romantic relationships</subject><subject>Self Report</subject><subject>Serotonin reuptake inhibitors</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>Serotonin Uptake Inhibitors - adverse effects</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Side effects</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk2LFDEQhoMo7rj6A7xIXwQvPVaSTmeCIMj6CQse1HNIJ5WZjN2dNuleWPzzpplRwYMsFCSpPFUp3jeEPKWwpUDbl8ft0bgtA9psYQ1-j2yokLxmgsr7ZFMYUQNn8oI8yvkIAK2S8JBcMAGUNazZkJ9vwxDTdAi2sgcz7jFX0Vc5Dlh5NPOSTok-3oRxXyXszRzimA9hypVb0prs47ivZ0xDtWRcYTPOweFUSnPZ5iqM1fmIrorLPJUeWC4ekwfe9BmfnNdL8u39u69XH-vrzx8-Xb25rq2AZq4RkElOWwuMesNsp6xT6AUwx5VQgjPvXSfaTjn0ikkpRdcwvzPUdl1jOL8kL059pxR_LJhnPYRsse_NiHHJmgqxUwoUsLugjWqo4u1dUNoyVYQuKD2hNsWcE3o9pTCYdKsp6NVJfdTFSb06qWGNdehn5_ZLN6D7U_HbugI8PwMmW9P7ZEYb8l9u14KQFAr36sRhkfgmYNLZFvktupDQztrF8N8xXv9TbfswhvLgd7zFfIxLGot3murMNOgv65dbfxxtoMgpJf8FVQrRuw</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Marazziti, Donatella</creator><creator>Akiskal, Hagop S</creator><creator>Udo, Mieko</creator><creator>Picchetti, Michela</creator><creator>Baroni, Stefano</creator><creator>Massimetti, Gabriele</creator><creator>Albanese, Francesco</creator><creator>Dell׳Osso, Liliana</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>7QJ</scope></search><sort><creationdate>20140901</creationdate><title>Dimorphic changes of some features of loving relationships during long-term use of antidepressants in depressed outpatients</title><author>Marazziti, Donatella ; Akiskal, Hagop S ; Udo, Mieko ; Picchetti, Michela ; Baroni, Stefano ; Massimetti, Gabriele ; Albanese, Francesco ; Dell׳Osso, Liliana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-e0e27316c021fa2cb9cd9ef502d3959532ffdb56b9def927775b42f8a1cbb4a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antidepressant drugs</topic><topic>Antidepressants</topic><topic>Antidepressive Agents, Tricyclic - administration & dosage</topic><topic>Antidepressive Agents, Tricyclic - adverse effects</topic><topic>Attachment</topic><topic>Biological and medical sciences</topic><topic>Coitus</topic><topic>Depression</topic><topic>Depression - drug therapy</topic><topic>Depression - epidemiology</topic><topic>Depression - psychology</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Drug Administration Schedule</topic><topic>Emotional blunting</topic><topic>Family Characteristics</topic><topic>Female</topic><topic>Gender</topic><topic>Heterosexuality - psychology</topic><topic>Homosexuality - psychology</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Love</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Neuropharmacology</topic><topic>Object Attachment</topic><topic>Outpatients</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatry</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Romantic relationships</topic><topic>Self Report</topic><topic>Serotonin reuptake inhibitors</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>Serotonin Uptake Inhibitors - adverse effects</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Side effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marazziti, Donatella</creatorcontrib><creatorcontrib>Akiskal, Hagop S</creatorcontrib><creatorcontrib>Udo, Mieko</creatorcontrib><creatorcontrib>Picchetti, Michela</creatorcontrib><creatorcontrib>Baroni, Stefano</creatorcontrib><creatorcontrib>Massimetti, Gabriele</creatorcontrib><creatorcontrib>Albanese, Francesco</creatorcontrib><creatorcontrib>Dell׳Osso, Liliana</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marazziti, Donatella</au><au>Akiskal, Hagop S</au><au>Udo, Mieko</au><au>Picchetti, Michela</au><au>Baroni, Stefano</au><au>Massimetti, Gabriele</au><au>Albanese, Francesco</au><au>Dell׳Osso, Liliana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dimorphic changes of some features of loving relationships during long-term use of antidepressants in depressed outpatients</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>166</volume><spage>151</spage><epage>155</epage><pages>151-155</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Abstract The present study aimed at investigating the possible changes of some features of loving relationships during long-term treatment of depression with both selective serotonin reuptake inhibitors (SSRIs) and tricyclics (TCAs), by means of a specifically designed test, the so-called “Sex, Attachment, Love” (SALT) questionnaire. 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| ispartof | Journal of affective disorders, 2014-09, Vol.166, p.151-155 |
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| language | eng |
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| subjects | Adult Adult and adolescent clinical studies Antidepressant drugs Antidepressants Antidepressive Agents, Tricyclic - administration & dosage Antidepressive Agents, Tricyclic - adverse effects Attachment Biological and medical sciences Coitus Depression Depression - drug therapy Depression - epidemiology Depression - psychology Depressive Disorder, Major - drug therapy Depressive Disorder, Major - psychology Drug Administration Schedule Emotional blunting Family Characteristics Female Gender Heterosexuality - psychology Homosexuality - psychology Humans Italy - epidemiology Love Male Medical sciences Middle Aged Miscellaneous Mood disorders Neuropharmacology Object Attachment Outpatients Pharmacology. Drug treatments Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Romantic relationships Self Report Serotonin reuptake inhibitors Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - adverse effects Severity of Illness Index Sex Factors Side effects |
| title | Dimorphic changes of some features of loving relationships during long-term use of antidepressants in depressed outpatients |
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