Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker
Abstract Background Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD). Methods T2*-weighted MRI was pe...
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| Veröffentlicht in: | Alzheimer's & dementia 2014-01, Vol.10 (1), p.e19-e26 |
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| creator | van Rooden, Sanneke Versluis, Maarten J Liem, Michael K Milles, Julien Maier, Andrea B Oleksik, Ania M Webb, Andrew G van Buchem, Mark A van der Grond, Jeroen |
| description | Abstract Background Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD). Methods T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups. Results Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions ( P < .005), and this was associated with individual Mini-Mental State Examination scores ( r = −0.54, P < .05). Conclusion Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages. |
| doi_str_mv | 10.1016/j.jalz.2013.02.002 |
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The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD). Methods T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups. Results Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions ( P < .005), and this was associated with individual Mini-Mental State Examination scores ( r = −0.54, P < .05). Conclusion Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2013.02.002</identifier><identifier>PMID: 23712002</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>AD pathology ; Aged ; Aged, 80 and over ; Alzheimer Disease - pathology ; Alzheimer's disease ; Biological markers ; Biomarker ; Brain imaging ; Cerebral Cortex - pathology ; Entorhinal cortex ; Female ; Hippocampus ; Human 7T MRI ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Neurology ; Pathology ; Phase changes ; Statistics, Nonparametric</subject><ispartof>Alzheimer's & dementia, 2014-01, Vol.10 (1), p.e19-e26</ispartof><rights>The Alzheimer's Association</rights><rights>2014 The Alzheimer's Association</rights><rights>Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5932-cf7bbe96b9694e849b3a78d3f4ca486bfa1daa1367d52d7f606fac101ff34c4b3</citedby><cites>FETCH-LOGICAL-c5932-cf7bbe96b9694e849b3a78d3f4ca486bfa1daa1367d52d7f606fac101ff34c4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2013.02.002$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2013.02.002$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,30999,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23712002$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Rooden, Sanneke</creatorcontrib><creatorcontrib>Versluis, Maarten J</creatorcontrib><creatorcontrib>Liem, Michael K</creatorcontrib><creatorcontrib>Milles, Julien</creatorcontrib><creatorcontrib>Maier, Andrea B</creatorcontrib><creatorcontrib>Oleksik, Ania M</creatorcontrib><creatorcontrib>Webb, Andrew G</creatorcontrib><creatorcontrib>van Buchem, Mark A</creatorcontrib><creatorcontrib>van der Grond, Jeroen</creatorcontrib><title>Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Abstract Background Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD). Methods T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups. Results Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions ( P < .005), and this was associated with individual Mini-Mental State Examination scores ( r = −0.54, P < .05). Conclusion Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.</description><subject>AD pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Biological markers</subject><subject>Biomarker</subject><subject>Brain imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Entorhinal cortex</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Human 7T MRI</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neurology</subject><subject>Pathology</subject><subject>Phase changes</subject><subject>Statistics, Nonparametric</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNUk1vEzEUXCEQLYU_wAH5Bpcszx-7XiNUaRVRaBVUCcqFi-X1vk283Y9gJ63SX49XCT1wgFxsy54Zv_dmkuQ1hZQCzd-3aWu6h5QB5SmwFIA9SU5plrFZxqR6-njO4SR5EUILIKCg2fPkhHFJWcSfJtfz0W-cNR1Zr0xAYldmWGIgbiBl97BC16N_G0jtAk7PZkPkDfn67fIDKckw3mFHXG-WbliS3vhb9C-TZ43pAr467GfJj4tPN_Mvs8X158t5uZjZTHE2s42sKlR5pXIlsBCq4kYWNW-ENaLIq8bQ2hjKc1lnrJZNDnljbOy6abiwouJnybu97tqPv7YYNrp3wWLXmQHHbdCx9UIpyJQ6AspFQWUuiiOgAFIWBYP_Q4UCKbIMpgLYHmr9GILHRq99nJrfaQp6clK3enJST05qYDo6E0lvDvrbqsf6kfLHuggo94B71-HuCEldLn5eXcVluoODxse9Bkar7hx6HazDwWLtPNqNrkf37xrP_6Lbzg1Tmm5xh6Edt36IIdBUh0jQ36c8TnGM38c5Msp_A_oZ1Kw</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>van Rooden, Sanneke</creator><creator>Versluis, Maarten J</creator><creator>Liem, Michael K</creator><creator>Milles, Julien</creator><creator>Maier, Andrea B</creator><creator>Oleksik, Ania M</creator><creator>Webb, Andrew G</creator><creator>van Buchem, Mark A</creator><creator>van der Grond, Jeroen</creator><general>Elsevier Inc</general><general>ALZHEIMER'S & DEMENTIA</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7QJ</scope></search><sort><creationdate>201401</creationdate><title>Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker</title><author>van Rooden, Sanneke ; Versluis, Maarten J ; Liem, Michael K ; Milles, Julien ; Maier, Andrea B ; Oleksik, Ania M ; Webb, Andrew G ; van Buchem, Mark A ; van der Grond, Jeroen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5932-cf7bbe96b9694e849b3a78d3f4ca486bfa1daa1367d52d7f606fac101ff34c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>AD pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Biological markers</topic><topic>Biomarker</topic><topic>Brain imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Entorhinal cortex</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Human 7T MRI</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neurology</topic><topic>Pathology</topic><topic>Phase changes</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Rooden, Sanneke</creatorcontrib><creatorcontrib>Versluis, Maarten J</creatorcontrib><creatorcontrib>Liem, Michael K</creatorcontrib><creatorcontrib>Milles, Julien</creatorcontrib><creatorcontrib>Maier, Andrea B</creatorcontrib><creatorcontrib>Oleksik, Ania M</creatorcontrib><creatorcontrib>Webb, Andrew G</creatorcontrib><creatorcontrib>van Buchem, Mark A</creatorcontrib><creatorcontrib>van der Grond, Jeroen</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Rooden, Sanneke</au><au>Versluis, Maarten J</au><au>Liem, Michael K</au><au>Milles, Julien</au><au>Maier, Andrea B</au><au>Oleksik, Ania M</au><au>Webb, Andrew G</au><au>van Buchem, Mark A</au><au>van der Grond, Jeroen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2014-01</date><risdate>2014</risdate><volume>10</volume><issue>1</issue><spage>e19</spage><epage>e26</epage><pages>e19-e26</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Abstract Background Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD). Methods T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups. Results Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions ( P < .005), and this was associated with individual Mini-Mental State Examination scores ( r = −0.54, P < .05). Conclusion Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23712002</pmid><doi>10.1016/j.jalz.2013.02.002</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | AD pathology Aged Aged, 80 and over Alzheimer Disease - pathology Alzheimer's disease Biological markers Biomarker Brain imaging Cerebral Cortex - pathology Entorhinal cortex Female Hippocampus Human 7T MRI Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Neurology Pathology Phase changes Statistics, Nonparametric |
| title | Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker |
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