Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population
Abstract Background In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the...
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| Veröffentlicht in: | Journal of affective disorders 2014-06, Vol.161, p.73-78 |
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| creator | Shen, Xinhua Wu, Yanfeng Guan, Tiefeng Wang, Xiaoquan Qian, Mincai Lin, Min Shen, Zhongxia Sun, Jushui Zhong, Hua Yang, Jianhong Li, Liang Yuan, Yonggui |
| description | Abstract Background In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. In this study, we investigate the association of COMT/MTHFR and their interactions with MDD and antidepressant response in Chinese Han population. Methods Three hundred and sixty eight depressed patients who met DSM-IV criteria for MDD were recruited for the study. Two hundred and nineteen normal controls were recruited from the local community. Patients and normal controls were genotyped for the functional COMT val158met and MTHFR C677T polymorphisms. Patients were characterized for clinical response to antidepressant treatment as measured by intra-individual changes of Hamilton Depression (HAMD-17) scores over 6 weeks. Results The T allele (OR=1.81; CI95%=1.40–2.34, P |
| doi_str_mv | 10.1016/j.jad.2014.03.008 |
| format | Article |
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In this study, we investigate the association of COMT/MTHFR and their interactions with MDD and antidepressant response in Chinese Han population. Methods Three hundred and sixty eight depressed patients who met DSM-IV criteria for MDD were recruited for the study. Two hundred and nineteen normal controls were recruited from the local community. Patients and normal controls were genotyped for the functional COMT val158met and MTHFR C677T polymorphisms. Patients were characterized for clinical response to antidepressant treatment as measured by intra-individual changes of Hamilton Depression (HAMD-17) scores over 6 weeks. Results The T allele (OR=1.81; CI95%=1.40–2.34, P <0.001) and C/T genotype (OR=3.66; CI95% =2.53–5.28, P <0.001) of MTHFR C677T were significantly different between case and control groups. The COMT Met/Val genotype was more common among depressed individuals than among controls (OR=1.52, CI95%=1.04–2.21, P =0.02). Limitation There is disequilibrium in age and sex between case and control groups. Though we control the two variables in the statistic analysis, to be more accurate, we need to increase sample size in further study. Conclusion Individuals with the genotype COMT Met/Val and MTHFR C/T have more probability of suffering from MDD. However, there is no association between gene polymorphism and treatment response.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2014.03.008</identifier><identifier>PMID: 24751310</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Alleles ; Antidepressant drugs ; Antidepressant response ; Antidepressive Agents - therapeutic use ; Base Sequence ; Biological and medical sciences ; Catechol O-Methyltransferase - genetics ; Catechol-O-methyltransferase ; Depression ; Depressive Disorder, Major - drug therapy ; Depressive Disorder, Major - genetics ; Depressive personality disorders ; Diagnostic and Statistical Manual of Mental Disorders ; DNA Primers ; Female ; Genes ; Genotype ; Humans ; Major depressive disorder ; Male ; Medical sciences ; Methylenetetrahydrofolate reductase ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; Miscellaneous ; Mood disorders ; Neuropharmacology ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Polymorphism ; Polymorphism, Single Nucleotide ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Suffering</subject><ispartof>Journal of affective disorders, 2014-06, Vol.161, p.73-78</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-ac80f6677e154d5de854af143c96f5c11f474f5f4382a6c345a07d345245f3d3</citedby><cites>FETCH-LOGICAL-c504t-ac80f6677e154d5de854af143c96f5c11f474f5f4382a6c345a07d345245f3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165032714001104$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28422408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24751310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Xinhua</creatorcontrib><creatorcontrib>Wu, Yanfeng</creatorcontrib><creatorcontrib>Guan, Tiefeng</creatorcontrib><creatorcontrib>Wang, Xiaoquan</creatorcontrib><creatorcontrib>Qian, Mincai</creatorcontrib><creatorcontrib>Lin, Min</creatorcontrib><creatorcontrib>Shen, Zhongxia</creatorcontrib><creatorcontrib>Sun, Jushui</creatorcontrib><creatorcontrib>Zhong, Hua</creatorcontrib><creatorcontrib>Yang, Jianhong</creatorcontrib><creatorcontrib>Li, Liang</creatorcontrib><creatorcontrib>Yuan, Yonggui</creatorcontrib><title>Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Background In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. In this study, we investigate the association of COMT/MTHFR and their interactions with MDD and antidepressant response in Chinese Han population. Methods Three hundred and sixty eight depressed patients who met DSM-IV criteria for MDD were recruited for the study. Two hundred and nineteen normal controls were recruited from the local community. Patients and normal controls were genotyped for the functional COMT val158met and MTHFR C677T polymorphisms. Patients were characterized for clinical response to antidepressant treatment as measured by intra-individual changes of Hamilton Depression (HAMD-17) scores over 6 weeks. Results The T allele (OR=1.81; CI95%=1.40–2.34, P <0.001) and C/T genotype (OR=3.66; CI95% =2.53–5.28, P <0.001) of MTHFR C677T were significantly different between case and control groups. The COMT Met/Val genotype was more common among depressed individuals than among controls (OR=1.52, CI95%=1.04–2.21, P =0.02). Limitation There is disequilibrium in age and sex between case and control groups. Though we control the two variables in the statistic analysis, to be more accurate, we need to increase sample size in further study. Conclusion Individuals with the genotype COMT Met/Val and MTHFR C/T have more probability of suffering from MDD. However, there is no association between gene polymorphism and treatment response.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Antidepressant drugs</subject><subject>Antidepressant response</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Catechol-O-methyltransferase</subject><subject>Depression</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Depressive Disorder, Major - genetics</subject><subject>Depressive personality disorders</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>DNA Primers</subject><subject>Female</subject><subject>Genes</subject><subject>Genotype</subject><subject>Humans</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylenetetrahydrofolate reductase</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychiatry</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Suffering</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk9rGzEQxZfS0rhpP0AvZS-FXNYZ_dtdUygE09SFhEDru1ClEdZ2d7XV2AF_-8qxk0IPJae5_N4bad4rivcM5gxYfdnNO-PmHJicg5gDtC-KGVONqLhizctilhlVgeDNWfGGqAOAetHA6-KMy0YxwWBWbK6Iog1mG-JYmtH0ewpURl8u727Xl7fr1fX3cor9fohp2gQaKEOuHEwXU-lwSkgU7rF0gWJymMowlstNGJGwXJkxS6dd_2D-tnjlTU_47jTPi_X1l_VyVd3cff22vLqprAK5rYxtwdd10yBT0imHrZLGMynsovbKMuZlI73yUrTc1FZIZaBxeXCpvHDivLg42k4p_t4hbfUQyGLfmxHjjjRTql0sgAt4BipkK1WzaJ-Bsrbm-eoqo-yI2hSJEno9pTCYtNcM9CE13emcmj6kpkHonFrWfDjZ734O6J4UjzFl4OMJMGRN75MZbaC_XCs5lw9Gn44c5gvfB0yabMDRogsJ7Va7GP77jM__qG0fxpAX_sI9Uhd3KRck_1YT16B_HOp1aBeTAIyBFH8AVfvH3Q</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Shen, Xinhua</creator><creator>Wu, Yanfeng</creator><creator>Guan, Tiefeng</creator><creator>Wang, Xiaoquan</creator><creator>Qian, Mincai</creator><creator>Lin, Min</creator><creator>Shen, Zhongxia</creator><creator>Sun, Jushui</creator><creator>Zhong, Hua</creator><creator>Yang, Jianhong</creator><creator>Li, Liang</creator><creator>Yuan, Yonggui</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7QJ</scope></search><sort><creationdate>20140601</creationdate><title>Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population</title><author>Shen, Xinhua ; Wu, Yanfeng ; Guan, Tiefeng ; Wang, Xiaoquan ; Qian, Mincai ; Lin, Min ; Shen, Zhongxia ; Sun, Jushui ; Zhong, Hua ; Yang, Jianhong ; Li, Liang ; Yuan, Yonggui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-ac80f6677e154d5de854af143c96f5c11f474f5f4382a6c345a07d345245f3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Antidepressant drugs</topic><topic>Antidepressant response</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Catechol-O-methyltransferase</topic><topic>Depression</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Depressive Disorder, Major - genetics</topic><topic>Depressive personality disorders</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>DNA Primers</topic><topic>Female</topic><topic>Genes</topic><topic>Genotype</topic><topic>Humans</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylenetetrahydrofolate reductase</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psychiatry</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Suffering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Xinhua</creatorcontrib><creatorcontrib>Wu, Yanfeng</creatorcontrib><creatorcontrib>Guan, Tiefeng</creatorcontrib><creatorcontrib>Wang, Xiaoquan</creatorcontrib><creatorcontrib>Qian, Mincai</creatorcontrib><creatorcontrib>Lin, Min</creatorcontrib><creatorcontrib>Shen, Zhongxia</creatorcontrib><creatorcontrib>Sun, Jushui</creatorcontrib><creatorcontrib>Zhong, Hua</creatorcontrib><creatorcontrib>Yang, Jianhong</creatorcontrib><creatorcontrib>Li, Liang</creatorcontrib><creatorcontrib>Yuan, Yonggui</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Xinhua</au><au>Wu, Yanfeng</au><au>Guan, Tiefeng</au><au>Wang, Xiaoquan</au><au>Qian, Mincai</au><au>Lin, Min</au><au>Shen, Zhongxia</au><au>Sun, Jushui</au><au>Zhong, Hua</au><au>Yang, Jianhong</au><au>Li, Liang</au><au>Yuan, Yonggui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>161</volume><spage>73</spage><epage>78</epage><pages>73-78</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Abstract Background In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. In this study, we investigate the association of COMT/MTHFR and their interactions with MDD and antidepressant response in Chinese Han population. Methods Three hundred and sixty eight depressed patients who met DSM-IV criteria for MDD were recruited for the study. Two hundred and nineteen normal controls were recruited from the local community. Patients and normal controls were genotyped for the functional COMT val158met and MTHFR C677T polymorphisms. Patients were characterized for clinical response to antidepressant treatment as measured by intra-individual changes of Hamilton Depression (HAMD-17) scores over 6 weeks. Results The T allele (OR=1.81; CI95%=1.40–2.34, P <0.001) and C/T genotype (OR=3.66; CI95% =2.53–5.28, P <0.001) of MTHFR C677T were significantly different between case and control groups. The COMT Met/Val genotype was more common among depressed individuals than among controls (OR=1.52, CI95%=1.04–2.21, P =0.02). Limitation There is disequilibrium in age and sex between case and control groups. Though we control the two variables in the statistic analysis, to be more accurate, we need to increase sample size in further study. Conclusion Individuals with the genotype COMT Met/Val and MTHFR C/T have more probability of suffering from MDD. However, there is no association between gene polymorphism and treatment response.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>24751310</pmid><doi>10.1016/j.jad.2014.03.008</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Alleles Antidepressant drugs Antidepressant response Antidepressive Agents - therapeutic use Base Sequence Biological and medical sciences Catechol O-Methyltransferase - genetics Catechol-O-methyltransferase Depression Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Depressive personality disorders Diagnostic and Statistical Manual of Mental Disorders DNA Primers Female Genes Genotype Humans Major depressive disorder Male Medical sciences Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Miscellaneous Mood disorders Neuropharmacology Pharmacology. Drug treatments Polymerase Chain Reaction Polymorphism Polymorphism, Single Nucleotide Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Suffering |
| title | Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population |
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