$Rapid clozapine titration in treatment-refractory bipolar disorder$

Rapid clozapine titration in treatment-refractory bipolar disorder

Abstract Background Clozapine is effective in treatment-refractory bipolar disorder (BD). Guidelines recommend slow titration to prevent seizures, hypotension and myocarditis, but this stance is not supported by comparative data. Objective To evaluate the safety and effectiveness of rapid clozapine...

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Veröffentlicht in:	Journal of affective disorders 2014-09, Vol.166, p.168-172
Hauptverfasser:	Ifteni, Petru, Correll, Christoph U, Nielsen, Jimmi, Burtea, Victoria, Kane, John M, Manu, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Antipsychotic Agents - administration & dosage Antipsychotic Agents - adverse effects Biological and medical sciences Bipolar affective disorder Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - psychology Bipolar disorders Clozapine Clozapine - administration & dosage Clozapine - adverse effects Cohort Studies Day Care, Medical Discharge Drug Administration Schedule Female Gender Hospitalization Hospitals Hospitals, Psychiatric Humans Hypotension Length of Stay Male Medical Records Medical sciences Middle Aged Miscellaneous Mood disorders Neuropharmacology Pharmacology. Drug treatments Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Rapid titration Readiness Retrospective Studies Symptom control Tolerability Treatment Outcome
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