The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells

The structurally related immunosuppressive macrolides FK-506 and rapamycin (RAP) were previously shown to inhibit T cell stimulation through different mechanisms. FK-506 acts similarly to cyclosporin A (CsA) and prevents IL-2 production and IL-2R expression. RAP has little or no effect on these even...

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Veröffentlicht in:	The Journal of immunology (1950) 1990-02, Vol.144 (4), p.1418-1424
Hauptverfasser:	Dumont, FJ, Melino, MR, Staruch, MJ, Koprak, SL, Fischer, PA, Sigal, NH
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - antagonists & inhibitors Anti-Bacterial Agents - pharmacology Binding, Competitive Biological and medical sciences Cyclosporins - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression - drug effects Immunobiology Immunosuppressive Agents - pharmacology In Vitro Techniques Interleukin-2 - genetics Ionomycin - pharmacology Lymphocyte Activation - drug effects Mice Mice, Inbred C57BL Modulation of the immune response (stimulation, suppression) Polyenes - antagonists & inhibitors Polyenes - pharmacology Receptors, Interleukin-2 - metabolism Signal Transduction - drug effects Sirolimus T-Lymphocytes - drug effects Tacrolimus Tetradecanoylphorbol Acetate - pharmacology
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