Influence of air pollution on humoral immune response
To learn more about the effects of ambient air pollution on the human immune system, immunological parameters—16 serum proteins and circulating immune complexes—were determined for more than 500 women from the polluted area of Cologne, Germany, and a control area, Borken. The geometric mean values f...
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| Veröffentlicht in: | Journal of clinical epidemiology 1996-05, Vol.49 (5), p.527-534 |
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| creator | Stiller-Winkler, Renate Idel, Helga Leng, Gabriele Spix, Claudia Dolgner, Reinhard |
| description | To learn more about the effects of ambient air pollution on the human immune system, immunological parameters—16 serum proteins and circulating immune complexes—were determined for more than 500 women from the polluted area of Cologne, Germany, and a control area, Borken. The geometric mean values for immunoglobulins, complement components, haptoglobin, α1-acid glycoprotein, α
1-antitrypsin, ceruloplasmin, α
2-macroglobulin, prealbumin, and transferrin were statistically significantly higher in Cologne than in Borken. No differences were found for C-reactive protein, rheumatoid factors, and anti-streptolysin O. For each of the parameters a logistic regression was fitted, thus controlling for the influence of a number of confounding factors. After controlling for possible confounders, the percentages of values above the norm for immunoglobulins, complement components, haptoglobin, and α-1-glycoprotein were statistically significantly higher in Cologne than in Borken. Important confounders included overweight, high blood pressure, acute cold, fever in the preceding week, and smoking. The biochemical mechanisms underlying the observed interarea differences in protein profiles are as yet unknown and should be the subject of further, nonepidemiological research. |
| doi_str_mv | 10.1016/0895-4356(95)00579-X |
| format | Article |
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1-antitrypsin, ceruloplasmin, α
2-macroglobulin, prealbumin, and transferrin were statistically significantly higher in Cologne than in Borken. No differences were found for C-reactive protein, rheumatoid factors, and anti-streptolysin O. For each of the parameters a logistic regression was fitted, thus controlling for the influence of a number of confounding factors. After controlling for possible confounders, the percentages of values above the norm for immunoglobulins, complement components, haptoglobin, and α-1-glycoprotein were statistically significantly higher in Cologne than in Borken. Important confounders included overweight, high blood pressure, acute cold, fever in the preceding week, and smoking. The biochemical mechanisms underlying the observed interarea differences in protein profiles are as yet unknown and should be the subject of further, nonepidemiological research.</description><identifier>ISSN: 0895-4356</identifier><identifier>EISSN: 1878-5921</identifier><identifier>DOI: 10.1016/0895-4356(95)00579-X</identifier><identifier>PMID: 8636726</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Air ; Air Pollutants - analysis ; Air Pollutants - immunology ; Air Pollutants - pharmacology ; air pollution ; analysis ; Antibody Formation - drug effects ; Biological and medical sciences ; Blood Proteins - drug effects ; Confounding Factors (Epidemiology) ; Environmental pollutants toxicology ; Epidemiology ; Female ; Germany ; Health Status ; Humans ; humoral immune response ; Immunoglobulins - drug effects ; Immunomonitoring ; Medical sciences ; Middle Aged ; multivariate ; Regression Analysis ; study design ; Toxicology</subject><ispartof>Journal of clinical epidemiology, 1996-05, Vol.49 (5), p.527-534</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-5ed105c5d4ffccc5e89d40900ddf3bb41fc9a7539500b38e5b3b3bde1bd9c9063</citedby><cites>FETCH-LOGICAL-c417t-5ed105c5d4ffccc5e89d40900ddf3bb41fc9a7539500b38e5b3b3bde1bd9c9063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0895-4356(95)00579-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3190763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8636726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stiller-Winkler, Renate</creatorcontrib><creatorcontrib>Idel, Helga</creatorcontrib><creatorcontrib>Leng, Gabriele</creatorcontrib><creatorcontrib>Spix, Claudia</creatorcontrib><creatorcontrib>Dolgner, Reinhard</creatorcontrib><title>Influence of air pollution on humoral immune response</title><title>Journal of clinical epidemiology</title><addtitle>J Clin Epidemiol</addtitle><description>To learn more about the effects of ambient air pollution on the human immune system, immunological parameters—16 serum proteins and circulating immune complexes—were determined for more than 500 women from the polluted area of Cologne, Germany, and a control area, Borken. The geometric mean values for immunoglobulins, complement components, haptoglobin, α1-acid glycoprotein, α
1-antitrypsin, ceruloplasmin, α
2-macroglobulin, prealbumin, and transferrin were statistically significantly higher in Cologne than in Borken. No differences were found for C-reactive protein, rheumatoid factors, and anti-streptolysin O. For each of the parameters a logistic regression was fitted, thus controlling for the influence of a number of confounding factors. After controlling for possible confounders, the percentages of values above the norm for immunoglobulins, complement components, haptoglobin, and α-1-glycoprotein were statistically significantly higher in Cologne than in Borken. Important confounders included overweight, high blood pressure, acute cold, fever in the preceding week, and smoking. The biochemical mechanisms underlying the observed interarea differences in protein profiles are as yet unknown and should be the subject of further, nonepidemiological research.</description><subject>Air</subject><subject>Air Pollutants - analysis</subject><subject>Air Pollutants - immunology</subject><subject>Air Pollutants - pharmacology</subject><subject>air pollution</subject><subject>analysis</subject><subject>Antibody Formation - drug effects</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - drug effects</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Environmental pollutants toxicology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Germany</subject><subject>Health Status</subject><subject>Humans</subject><subject>humoral immune response</subject><subject>Immunoglobulins - drug effects</subject><subject>Immunomonitoring</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>multivariate</subject><subject>Regression Analysis</subject><subject>study design</subject><subject>Toxicology</subject><issn>0895-4356</issn><issn>1878-5921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A4UeRPRQnZhO21wEWfyCBS8KewtpMsFI26zJVvDf23WXPcoMzOF9Zhgexk45XHPg5Q3UEvNCYHkp8QoAK5nPd9iE11Wdo7zlu2yyRQ7YYUqfALyCCvfZfl2KsrotJwxfetcO1BvKgsu0j9kitO2w9KHPxv4YuhB1m_muG3rKIqVF6BMdsz2n20Qnm3nE3h8f3qbP-ez16WV6P8tNwatljmQ5oEFbOGeMQaqlLUACWOtE0xTcGakrFBIBGlETNmIsS7yx0kgoxRG7WN9dxPA1UFqqzidDbat7CkNSHLFGKYsRLNagiSGlSE4tou90_FEc1MqWWqlQKxVqnH-21HxcO9vcH5qO7HZpo2fMzze5Tka3Lure-LTFBJdQlWLE7tYYjS6-PUWVjF85tT6SWSob_P9__AKwqIZo</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>Stiller-Winkler, Renate</creator><creator>Idel, Helga</creator><creator>Leng, Gabriele</creator><creator>Spix, Claudia</creator><creator>Dolgner, Reinhard</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19960501</creationdate><title>Influence of air pollution on humoral immune response</title><author>Stiller-Winkler, Renate ; Idel, Helga ; Leng, Gabriele ; Spix, Claudia ; Dolgner, Reinhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-5ed105c5d4ffccc5e89d40900ddf3bb41fc9a7539500b38e5b3b3bde1bd9c9063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Air</topic><topic>Air Pollutants - analysis</topic><topic>Air Pollutants - immunology</topic><topic>Air Pollutants - pharmacology</topic><topic>air pollution</topic><topic>analysis</topic><topic>Antibody Formation - drug effects</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - drug effects</topic><topic>Confounding Factors (Epidemiology)</topic><topic>Environmental pollutants toxicology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Germany</topic><topic>Health Status</topic><topic>Humans</topic><topic>humoral immune response</topic><topic>Immunoglobulins - drug effects</topic><topic>Immunomonitoring</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>multivariate</topic><topic>Regression Analysis</topic><topic>study design</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stiller-Winkler, Renate</creatorcontrib><creatorcontrib>Idel, Helga</creatorcontrib><creatorcontrib>Leng, Gabriele</creatorcontrib><creatorcontrib>Spix, Claudia</creatorcontrib><creatorcontrib>Dolgner, Reinhard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of clinical epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stiller-Winkler, Renate</au><au>Idel, Helga</au><au>Leng, Gabriele</au><au>Spix, Claudia</au><au>Dolgner, Reinhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of air pollution on humoral immune response</atitle><jtitle>Journal of clinical epidemiology</jtitle><addtitle>J Clin Epidemiol</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>49</volume><issue>5</issue><spage>527</spage><epage>534</epage><pages>527-534</pages><issn>0895-4356</issn><eissn>1878-5921</eissn><abstract>To learn more about the effects of ambient air pollution on the human immune system, immunological parameters—16 serum proteins and circulating immune complexes—were determined for more than 500 women from the polluted area of Cologne, Germany, and a control area, Borken. The geometric mean values for immunoglobulins, complement components, haptoglobin, α1-acid glycoprotein, α
1-antitrypsin, ceruloplasmin, α
2-macroglobulin, prealbumin, and transferrin were statistically significantly higher in Cologne than in Borken. No differences were found for C-reactive protein, rheumatoid factors, and anti-streptolysin O. For each of the parameters a logistic regression was fitted, thus controlling for the influence of a number of confounding factors. After controlling for possible confounders, the percentages of values above the norm for immunoglobulins, complement components, haptoglobin, and α-1-glycoprotein were statistically significantly higher in Cologne than in Borken. Important confounders included overweight, high blood pressure, acute cold, fever in the preceding week, and smoking. The biochemical mechanisms underlying the observed interarea differences in protein profiles are as yet unknown and should be the subject of further, nonepidemiological research.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8636726</pmid><doi>10.1016/0895-4356(95)00579-X</doi><tpages>8</tpages></addata></record> |
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| subjects | Air Air Pollutants - analysis Air Pollutants - immunology Air Pollutants - pharmacology air pollution analysis Antibody Formation - drug effects Biological and medical sciences Blood Proteins - drug effects Confounding Factors (Epidemiology) Environmental pollutants toxicology Epidemiology Female Germany Health Status Humans humoral immune response Immunoglobulins - drug effects Immunomonitoring Medical sciences Middle Aged multivariate Regression Analysis study design Toxicology |
| title | Influence of air pollution on humoral immune response |
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