Force-clamp experiments reveal the free-energy profile and diffusion coefficient of the collapse of protein molecules

We present force-clamp data on the collapse of ubiquitin polyproteins from a highly extended state to the folded length, in response to a quench in the force from 110 pN to 5 or 10 pN. Using a recent method for free-energy reconstruction from the observed nonequilibrium trajectories, we find that th...

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Veröffentlicht in:	Physical review letters 2013-03, Vol.110 (12), p.128301-128301, Article 128301
Hauptverfasser:	Lannon, H, Haghpanah, J S, Montclare, J K, Vanden-Eijnden, E, Brujic, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Diffusion Microscopy, Atomic Force Protein Folding Proteins - chemistry Thermodynamics Ubiquitin - chemistry
Online-Zugang:	Volltext
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