Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population
Cyclin E1 (CCNE1) is a key proto-oncogene. The present study aimed to investigate the effects of single nucleotide polymorphisms in CCNE1 on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women w...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2014-10, Vol.31 (10), p.189-189, Article 189 |
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| container_title | Medical oncology (Northwood, London, England) |
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| creator | Amininia, Shadi Hashemi, Mohammad Ebrahimi, Mahboubeh Mashhadi, Mohammad Ali Hashemi, Seyed Mehdi Taheri, Mohsen Ghavami, Saeid |
| description | Cyclin E1 (CCNE1) is a key proto-oncogene. The present study aimed to investigate the effects of single nucleotide polymorphisms in
CCNE1
on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women were participated in the study. Genotyping of
CCNE1
rs3218073 and 72010703 polymorphisms was done using allele-specific polymerase chain reaction (AS-PCR) and rs1406 by PCR–RFLP method.Our findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95 % CI 1.05–2.43,
p
= 0.032 CA vs CC; OR 2.35, 95 % CI 1.23–4.49,
p
= 0.011 AA vs CC) and dominant (OR 1.69, 95 % CI 1.22–2.56,
p
= 0.012 CA + AA vs CC) inheritance models. The rs1406 A allele increased the risk of BC (OR 1.37, 95 % CI 1.06–1.76,
p
= 0.019) in comparison with C allele. On the other hand,
CCNE1
rs72010703 (4-bp I/D) and rs3218073 polymorphisms did not show any significant association with BC. This study indicates that
CCNE1
rs1406 polymorphism may contribute to BC risk. |
| doi_str_mv | 10.1007/s12032-014-0189-z |
| format | Article |
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CCNE1
on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women were participated in the study. Genotyping of
CCNE1
rs3218073 and 72010703 polymorphisms was done using allele-specific polymerase chain reaction (AS-PCR) and rs1406 by PCR–RFLP method.Our findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95 % CI 1.05–2.43,
p
= 0.032 CA vs CC; OR 2.35, 95 % CI 1.23–4.49,
p
= 0.011 AA vs CC) and dominant (OR 1.69, 95 % CI 1.22–2.56,
p
= 0.012 CA + AA vs CC) inheritance models. The rs1406 A allele increased the risk of BC (OR 1.37, 95 % CI 1.06–1.76,
p
= 0.019) in comparison with C allele. On the other hand,
CCNE1
rs72010703 (4-bp I/D) and rs3218073 polymorphisms did not show any significant association with BC. This study indicates that
CCNE1
rs1406 polymorphism may contribute to BC risk.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-014-0189-z</identifier><identifier>PMID: 25159285</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Alleles ; Breast cancer ; Breast Neoplasms - genetics ; Case-Control Studies ; Cyclin E - genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Hematology ; Humans ; Internal Medicine ; Iran ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncogene Proteins - genetics ; Oncology ; Original Paper ; Pathology ; Polymerase Chain Reaction ; Polymorphism, Genetic</subject><ispartof>Medical oncology (Northwood, London, England), 2014-10, Vol.31 (10), p.189-189, Article 189</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-364c6288d2d75a3e9d85a2494d3e539b7a109ce104de87ec22b83ba1536bc0d33</citedby><cites>FETCH-LOGICAL-c442t-364c6288d2d75a3e9d85a2494d3e539b7a109ce104de87ec22b83ba1536bc0d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-014-0189-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-014-0189-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25159285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amininia, Shadi</creatorcontrib><creatorcontrib>Hashemi, Mohammad</creatorcontrib><creatorcontrib>Ebrahimi, Mahboubeh</creatorcontrib><creatorcontrib>Mashhadi, Mohammad Ali</creatorcontrib><creatorcontrib>Hashemi, Seyed Mehdi</creatorcontrib><creatorcontrib>Taheri, Mohsen</creatorcontrib><creatorcontrib>Ghavami, Saeid</creatorcontrib><title>Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Cyclin E1 (CCNE1) is a key proto-oncogene. The present study aimed to investigate the effects of single nucleotide polymorphisms in
CCNE1
on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women were participated in the study. Genotyping of
CCNE1
rs3218073 and 72010703 polymorphisms was done using allele-specific polymerase chain reaction (AS-PCR) and rs1406 by PCR–RFLP method.Our findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95 % CI 1.05–2.43,
p
= 0.032 CA vs CC; OR 2.35, 95 % CI 1.23–4.49,
p
= 0.011 AA vs CC) and dominant (OR 1.69, 95 % CI 1.22–2.56,
p
= 0.012 CA + AA vs CC) inheritance models. The rs1406 A allele increased the risk of BC (OR 1.37, 95 % CI 1.06–1.76,
p
= 0.019) in comparison with C allele. On the other hand,
CCNE1
rs72010703 (4-bp I/D) and rs3218073 polymorphisms did not show any significant association with BC. This study indicates that
CCNE1
rs1406 polymorphism may contribute to BC risk.</description><subject>Adult</subject><subject>Alleles</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Case-Control Studies</subject><subject>Cyclin E - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Iran</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncogene Proteins - genetics</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUtLxTAQhYMovn-AGwm4cVPNo2mbpVx8gehGwV1I07labZOaaRH99eZ6VURwMWTgfHMmzCFkj7Mjzlh5jFwwKTLG81SVzt5XyCZXSmdc8vvV1EtVZkwVbINsIT4xJrgSep1sCMWVFpXaJC8niMG1dmyDpzWMrwCezmbXp5wOoXvrQxweW-yRWt_Q8RFobPGZhjmtI1gcqbPeQaStp5ai7YcOFiKGKbEL_TJa31qfzIap-9yyQ9bmtkPY_Xq3yd3Z6e3sIru6Ob-cnVxlLs_FmMkid4WoqkY0pbISdFMpK3KdNxKU1HVpOdMOOMsbqEpwQtSVrC1Xsqgda6TcJodL3yGGlwlwNH2LDrrOeggTmnSoSomy1CqhB3_QpzBFn36XqKJQmqdLJoovKRcDYoS5GWLb2_hmODOLPMwyD5PyMIs8zHua2f9ynuoemp-J7wASIJYAJsk_QPy1-l_XD3pGli0</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Amininia, Shadi</creator><creator>Hashemi, Mohammad</creator><creator>Ebrahimi, Mahboubeh</creator><creator>Mashhadi, Mohammad Ali</creator><creator>Hashemi, Seyed Mehdi</creator><creator>Taheri, Mohsen</creator><creator>Ghavami, Saeid</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population</title><author>Amininia, Shadi ; Hashemi, Mohammad ; Ebrahimi, Mahboubeh ; Mashhadi, Mohammad Ali ; Hashemi, Seyed Mehdi ; Taheri, Mohsen ; Ghavami, Saeid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-364c6288d2d75a3e9d85a2494d3e539b7a109ce104de87ec22b83ba1536bc0d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Case-Control Studies</topic><topic>Cyclin E - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Iran</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncogene Proteins - genetics</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amininia, Shadi</creatorcontrib><creatorcontrib>Hashemi, Mohammad</creatorcontrib><creatorcontrib>Ebrahimi, Mahboubeh</creatorcontrib><creatorcontrib>Mashhadi, Mohammad Ali</creatorcontrib><creatorcontrib>Hashemi, Seyed Mehdi</creatorcontrib><creatorcontrib>Taheri, Mohsen</creatorcontrib><creatorcontrib>Ghavami, Saeid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amininia, Shadi</au><au>Hashemi, Mohammad</au><au>Ebrahimi, Mahboubeh</au><au>Mashhadi, Mohammad Ali</au><au>Hashemi, Seyed Mehdi</au><au>Taheri, Mohsen</au><au>Ghavami, Saeid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>31</volume><issue>10</issue><spage>189</spage><epage>189</epage><pages>189-189</pages><artnum>189</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>Cyclin E1 (CCNE1) is a key proto-oncogene. The present study aimed to investigate the effects of single nucleotide polymorphisms in
CCNE1
on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women were participated in the study. Genotyping of
CCNE1
rs3218073 and 72010703 polymorphisms was done using allele-specific polymerase chain reaction (AS-PCR) and rs1406 by PCR–RFLP method.Our findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95 % CI 1.05–2.43,
p
= 0.032 CA vs CC; OR 2.35, 95 % CI 1.23–4.49,
p
= 0.011 AA vs CC) and dominant (OR 1.69, 95 % CI 1.22–2.56,
p
= 0.012 CA + AA vs CC) inheritance models. The rs1406 A allele increased the risk of BC (OR 1.37, 95 % CI 1.06–1.76,
p
= 0.019) in comparison with C allele. On the other hand,
CCNE1
rs72010703 (4-bp I/D) and rs3218073 polymorphisms did not show any significant association with BC. This study indicates that
CCNE1
rs1406 polymorphism may contribute to BC risk.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25159285</pmid><doi>10.1007/s12032-014-0189-z</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1357-0560 |
| ispartof | Medical oncology (Northwood, London, England), 2014-10, Vol.31 (10), p.189-189, Article 189 |
| issn | 1357-0560 1559-131X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Alleles Breast cancer Breast Neoplasms - genetics Case-Control Studies Cyclin E - genetics Female Genetic Predisposition to Disease Genotype Hematology Humans Internal Medicine Iran Medicine Medicine & Public Health Middle Aged Oncogene Proteins - genetics Oncology Original Paper Pathology Polymerase Chain Reaction Polymorphism, Genetic |
| title | Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population |
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