Rheology of human blood plasma: viscoelastic versus Newtonian behavior
We investigate the rheological characteristics of human blood plasma in shear and elongational flows. While we can confirm a Newtonian behavior in shear flow within experimental resolution, we find a viscoelastic behavior of blood plasma in the pure extensional flow of a capillary breakup rheometer....
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| Veröffentlicht in: | Physical review letters 2013-02, Vol.110 (7), p.078305-078305, Article 078305 |
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| container_title | Physical review letters |
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| creator | Brust, M Schaefer, C Doerr, R Pan, L Garcia, M Arratia, P E Wagner, C |
| description | We investigate the rheological characteristics of human blood plasma in shear and elongational flows. While we can confirm a Newtonian behavior in shear flow within experimental resolution, we find a viscoelastic behavior of blood plasma in the pure extensional flow of a capillary breakup rheometer. The influence of the viscoelasticity of blood plasma on capillary blood flow is tested in a microfluidic device with a contraction-expansion geometry. Differential pressure measurements revealed that the plasma has a pronounced flow resistance compared to that of pure water. Supplementary measurements indicate that the viscoelasticity of the plasma might even lead to viscoelastic instabilities under certain conditions. Our findings show that the viscoelastic properties of plasma should not be ignored in future studies on blood flow. |
| doi_str_mv | 10.1103/physrevlett.110.078305 |
| format | Article |
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While we can confirm a Newtonian behavior in shear flow within experimental resolution, we find a viscoelastic behavior of blood plasma in the pure extensional flow of a capillary breakup rheometer. The influence of the viscoelasticity of blood plasma on capillary blood flow is tested in a microfluidic device with a contraction-expansion geometry. Differential pressure measurements revealed that the plasma has a pronounced flow resistance compared to that of pure water. Supplementary measurements indicate that the viscoelasticity of the plasma might even lead to viscoelastic instabilities under certain conditions. Our findings show that the viscoelastic properties of plasma should not be ignored in future studies on blood flow.</description><subject>Blood Viscosity - physiology</subject><subject>Humans</subject><subject>Microfluidic Analytical Techniques</subject><subject>Plasma - chemistry</subject><subject>Plasma - physiology</subject><subject>Rheology - methods</subject><subject>Viscosity</subject><issn>0031-9007</issn><issn>1079-7114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9Lw0AQxRdRbK1-hZKjl9TZbPZPvEmxKhSVouew2U5MJOnGbJLSb--GVk_DPN6befwImVNYUArsrikOrsWhwq4bhQVIxYCfkSkFmYSS0vicTAEYDRMAOSFXzn0DAI2EuiSTiFMhYiqnZLUp0Fb26xDYPCj6Wu-CrLJ2GzSVdrW-D4bSGYt-6UoTDNi63gWvuO_srhy9WOihtO01uch15fDmNGfkc_X4sXwO129PL8uHdWhiqbowk9sElNRCa42SCa0k6Fih75wow5nheZYlRjGMQUY5x4xHqESCCg0FLtiM3B7vNq396dF1ae37YVXpHdrepZRzxaOYJpG3iqPVtNZ5VnnatGWt20NKIR0Zpu-e4QaHtWc4CumRoQ_OTz_6rMbtf-wPGvsF8M1xFQ</recordid><startdate>20130215</startdate><enddate>20130215</enddate><creator>Brust, M</creator><creator>Schaefer, C</creator><creator>Doerr, R</creator><creator>Pan, L</creator><creator>Garcia, M</creator><creator>Arratia, P E</creator><creator>Wagner, C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130215</creationdate><title>Rheology of human blood plasma: viscoelastic versus Newtonian behavior</title><author>Brust, M ; Schaefer, C ; Doerr, R ; Pan, L ; Garcia, M ; Arratia, P E ; Wagner, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-b7d9087a6aaae736a870a48e07998c53c5fbb9c83e4072f5eb52e869e8ec10563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Blood Viscosity - physiology</topic><topic>Humans</topic><topic>Microfluidic Analytical Techniques</topic><topic>Plasma - chemistry</topic><topic>Plasma - physiology</topic><topic>Rheology - methods</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brust, M</creatorcontrib><creatorcontrib>Schaefer, C</creatorcontrib><creatorcontrib>Doerr, R</creatorcontrib><creatorcontrib>Pan, L</creatorcontrib><creatorcontrib>Garcia, M</creatorcontrib><creatorcontrib>Arratia, P E</creatorcontrib><creatorcontrib>Wagner, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physical review letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brust, M</au><au>Schaefer, C</au><au>Doerr, R</au><au>Pan, L</au><au>Garcia, M</au><au>Arratia, P E</au><au>Wagner, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheology of human blood plasma: viscoelastic versus Newtonian behavior</atitle><jtitle>Physical review letters</jtitle><addtitle>Phys Rev Lett</addtitle><date>2013-02-15</date><risdate>2013</risdate><volume>110</volume><issue>7</issue><spage>078305</spage><epage>078305</epage><pages>078305-078305</pages><artnum>078305</artnum><issn>0031-9007</issn><eissn>1079-7114</eissn><abstract>We investigate the rheological characteristics of human blood plasma in shear and elongational flows. 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| source | MEDLINE; APS: American Physical Society E-Journals (Physics) |
| subjects | Blood Viscosity - physiology Humans Microfluidic Analytical Techniques Plasma - chemistry Plasma - physiology Rheology - methods Viscosity |
| title | Rheology of human blood plasma: viscoelastic versus Newtonian behavior |
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