Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes
Histamine exerts its immunoregulatory effects via the activation of 4 different histamine receptors (named H1R to H4R).4 Activation of histamine receptor 2 (H2R) is associated with potent immunoregulatory effects, and the anti-inflammatory effects of a histamine-secreting L rhamnosus strain were los...
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| creator | Ferstl, Ruth, PhD Frei, Remo, PhD Schiavi, Elisa, PhD Konieczna, Patrycja, PhD Barcik, Weronika, MSc Ziegler, Mario, Dipl-Ing Lauener, Roger P., MD Chassard, Christophe, PhD Lacroix, Christophe, PhD Akdis, Cezmi A., MD O'Mahony, Liam, PhD |
| description | Histamine exerts its immunoregulatory effects via the activation of 4 different histamine receptors (named H1R to H4R).4 Activation of histamine receptor 2 (H2R) is associated with potent immunoregulatory effects, and the anti-inflammatory effects of a histamine-secreting L rhamnosus strain were lost in H2R-deficient animals, suggesting that histamine derived from the microbiota could be immunoregulatory.5 To extend this observation and determine whether this phenomenon is a common feature of histamine-secreting microbes, we performed in vitro and murine studies with another Lactobacillus that is well recognized for its ability to secrete high levels of histamine, L saerimneri strain 30a (ATCC 33222).6 In vitro, the strain performed as expected. In vitro studies have demonstrated that TLR responses to microbial ligands are significantly influenced by histamine signaling through H2R.5,8 In this report, we demonstrate that the H2R is required for IL-6 and IL-17 mucosal responses, suggesting that H2R is a critical immunoregulatory receptor that significantly influences the in vivo immune response to histamine-secreting microbes within the intestine. |
| doi_str_mv | 10.1016/j.jaci.2014.04.034 |
| format | Article |
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In vitro studies have demonstrated that TLR responses to microbial ligands are significantly influenced by histamine signaling through H2R.5,8 In this report, we demonstrate that the H2R is required for IL-6 and IL-17 mucosal responses, suggesting that H2R is a critical immunoregulatory receptor that significantly influences the in vivo immune response to histamine-secreting microbes within the intestine.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2014.04.034</identifier><identifier>PMID: 24954261</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Allergy and Immunology ; Animals ; Biological and medical sciences ; Cell Line ; Coculture Techniques ; Cytokines - metabolism ; Famotidine - pharmacology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Histamine - metabolism ; Homeostasis ; Humans ; Immunity - drug effects ; Immunomodulation ; Immunopathology ; Intestines - immunology ; Intestines - microbiology ; Lactobacillus - physiology ; Ligands ; Medical sciences ; Mice ; Mice, Inbred Strains ; Mice, Knockout ; Microbiota - immunology ; NF-kappa B - metabolism ; Receptors, Histamine H2 - genetics ; Receptors, Histamine H2 - metabolism ; Rodents ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Statistical analysis ; Studies</subject><ispartof>Journal of allergy and clinical immunology, 2014-09, Vol.134 (3), p.744-746.e3</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Limited Sep 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-e7a93e0506fc2188adcc5523e9dbfcec8f56845bbb9b7bdcc38bd27e717add43</citedby><cites>FETCH-LOGICAL-c530t-e7a93e0506fc2188adcc5523e9dbfcec8f56845bbb9b7bdcc38bd27e717add43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28828590$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24954261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferstl, Ruth, PhD</creatorcontrib><creatorcontrib>Frei, Remo, PhD</creatorcontrib><creatorcontrib>Schiavi, Elisa, PhD</creatorcontrib><creatorcontrib>Konieczna, Patrycja, PhD</creatorcontrib><creatorcontrib>Barcik, Weronika, MSc</creatorcontrib><creatorcontrib>Ziegler, Mario, Dipl-Ing</creatorcontrib><creatorcontrib>Lauener, Roger P., MD</creatorcontrib><creatorcontrib>Chassard, Christophe, PhD</creatorcontrib><creatorcontrib>Lacroix, Christophe, PhD</creatorcontrib><creatorcontrib>Akdis, Cezmi A., MD</creatorcontrib><creatorcontrib>O'Mahony, Liam, PhD</creatorcontrib><title>Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Histamine exerts its immunoregulatory effects via the activation of 4 different histamine receptors (named H1R to H4R).4 Activation of histamine receptor 2 (H2R) is associated with potent immunoregulatory effects, and the anti-inflammatory effects of a histamine-secreting L rhamnosus strain were lost in H2R-deficient animals, suggesting that histamine derived from the microbiota could be immunoregulatory.5 To extend this observation and determine whether this phenomenon is a common feature of histamine-secreting microbes, we performed in vitro and murine studies with another Lactobacillus that is well recognized for its ability to secrete high levels of histamine, L saerimneri strain 30a (ATCC 33222).6 In vitro, the strain performed as expected. In vitro studies have demonstrated that TLR responses to microbial ligands are significantly influenced by histamine signaling through H2R.5,8 In this report, we demonstrate that the H2R is required for IL-6 and IL-17 mucosal responses, suggesting that H2R is a critical immunoregulatory receptor that significantly influences the in vivo immune response to histamine-secreting microbes within the intestine.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Coculture Techniques</subject><subject>Cytokines - metabolism</subject><subject>Famotidine - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Histamine - metabolism</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immunity - drug effects</subject><subject>Immunomodulation</subject><subject>Immunopathology</subject><subject>Intestines - immunology</subject><subject>Intestines - microbiology</subject><subject>Lactobacillus - physiology</subject><subject>Ligands</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mice, Knockout</subject><subject>Microbiota - immunology</subject><subject>NF-kappa B - metabolism</subject><subject>Receptors, Histamine H2 - genetics</subject><subject>Receptors, Histamine H2 - metabolism</subject><subject>Rodents</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Histamine - metabolism</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immunity - drug effects</topic><topic>Immunomodulation</topic><topic>Immunopathology</topic><topic>Intestines - immunology</topic><topic>Intestines - microbiology</topic><topic>Lactobacillus - physiology</topic><topic>Ligands</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mice, Knockout</topic><topic>Microbiota - immunology</topic><topic>NF-kappa B - metabolism</topic><topic>Receptors, Histamine H2 - genetics</topic><topic>Receptors, Histamine H2 - metabolism</topic><topic>Rodents</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Statistical analysis</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferstl, Ruth, PhD</creatorcontrib><creatorcontrib>Frei, Remo, PhD</creatorcontrib><creatorcontrib>Schiavi, Elisa, PhD</creatorcontrib><creatorcontrib>Konieczna, Patrycja, PhD</creatorcontrib><creatorcontrib>Barcik, Weronika, MSc</creatorcontrib><creatorcontrib>Ziegler, Mario, Dipl-Ing</creatorcontrib><creatorcontrib>Lauener, Roger P., MD</creatorcontrib><creatorcontrib>Chassard, Christophe, PhD</creatorcontrib><creatorcontrib>Lacroix, Christophe, PhD</creatorcontrib><creatorcontrib>Akdis, Cezmi A., MD</creatorcontrib><creatorcontrib>O'Mahony, Liam, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferstl, Ruth, PhD</au><au>Frei, Remo, PhD</au><au>Schiavi, Elisa, PhD</au><au>Konieczna, Patrycja, PhD</au><au>Barcik, Weronika, MSc</au><au>Ziegler, Mario, Dipl-Ing</au><au>Lauener, Roger P., MD</au><au>Chassard, Christophe, PhD</au><au>Lacroix, Christophe, PhD</au><au>Akdis, Cezmi A., MD</au><au>O'Mahony, Liam, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>134</volume><issue>3</issue><spage>744</spage><epage>746.e3</epage><pages>744-746.e3</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Histamine exerts its immunoregulatory effects via the activation of 4 different histamine receptors (named H1R to H4R).4 Activation of histamine receptor 2 (H2R) is associated with potent immunoregulatory effects, and the anti-inflammatory effects of a histamine-secreting L rhamnosus strain were lost in H2R-deficient animals, suggesting that histamine derived from the microbiota could be immunoregulatory.5 To extend this observation and determine whether this phenomenon is a common feature of histamine-secreting microbes, we performed in vitro and murine studies with another Lactobacillus that is well recognized for its ability to secrete high levels of histamine, L saerimneri strain 30a (ATCC 33222).6 In vitro, the strain performed as expected. In vitro studies have demonstrated that TLR responses to microbial ligands are significantly influenced by histamine signaling through H2R.5,8 In this report, we demonstrate that the H2R is required for IL-6 and IL-17 mucosal responses, suggesting that H2R is a critical immunoregulatory receptor that significantly influences the in vivo immune response to histamine-secreting microbes within the intestine.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>24954261</pmid><doi>10.1016/j.jaci.2014.04.034</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Allergy and Immunology Animals Biological and medical sciences Cell Line Coculture Techniques Cytokines - metabolism Famotidine - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Histamine - metabolism Homeostasis Humans Immunity - drug effects Immunomodulation Immunopathology Intestines - immunology Intestines - microbiology Lactobacillus - physiology Ligands Medical sciences Mice Mice, Inbred Strains Mice, Knockout Microbiota - immunology NF-kappa B - metabolism Receptors, Histamine H2 - genetics Receptors, Histamine H2 - metabolism Rodents Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Statistical analysis Studies |
| title | Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes |
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