Simultaneous determination of dorzolomide and timolol in aqueous humor: A novel salting out liquid–liquid microextraction combined with HPLC

A Snovel method for the simultaneous separation and determination of two antiglaucoma drugs namely, dorzolamide hydrochloride (DOR) and timolol maleate (TIM) in aqueous humor samples (AH) was developed by using salting-out assisted liquid–liquid microextraction (SALLME) combined with HPLC–UV method....

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Veröffentlicht in:	Talanta (Oxford) 2014-12, Vol.130, p.495-505
Hauptverfasser:	Mohamed, Abdel-Maaboud Ismail, Abdel-Wadood, Hanaa Mohammed, Mousa, Heba Salah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous Humor - chemistry Box–Behnken experimental design Chromatography, High Pressure Liquid - methods Dorzolamide HCl Female HPLC–UV Limit of Detection Liquid Phase Microextraction - methods Male Rabbit aqueous humor Rabbits Salting-out assisted liquid–liquid microextraction Solvents - chemistry Sulfonamides - analysis Sulfonamides - isolation & purification Sulfonamides - pharmacokinetics Thiophenes - analysis Thiophenes - isolation & purification Thiophenes - pharmacokinetics Timolol - analysis Timolol - isolation & purification Timolol - pharmacokinetics Timolol maleate Tissue Distribution
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