The Molecular Mechanism of Intestinal Levodopa Absorption and Its Possible Implications for the Treatment of Parkinson’s Disease

Levodopa (L-DOPA) is the naturally occurring precursor amino acid for dopamine and the main therapeutic agent for neurologic disorders due to dopamine depletion, such as Parkinson’s disease. l-DOPA absorption in small intestine has been suggested to be mediated by the large neutral amino acids trans...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2014-10, Vol.351 (1), p.114-123
Hauptverfasser:	Camargo, Simone M.R., Vuille-dit-Bille, Raphael N., Mariotta, Luca, Ramadan, Tamara, Huggel, Katja, Singer, Dustin, Götze, Oliver, Verrey, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems, Basic - metabolism Amino Acid Transport Systems, Neutral - metabolism Animals Antiparkinson Agents - pharmacokinetics Dogs Humans Intestinal Absorption Intestine, Small - metabolism Levodopa - pharmacokinetics Madin Darby Canine Kidney Cells Mice Mice, Inbred C57BL Xenopus
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