Effect of DNA-Induced Corrosion on Passivated Porous Silicon Biosensors
This work examines the influence of charge density and surface passivation on the DNA-induced corrosion of porous silicon (PSi) waveguides in order to improve PSi biosensor sensitivity, reliability, and reproducibility when exposed to negatively charged DNA molecules. Increasing the concentration of...
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| Veröffentlicht in: | ACS applied materials & interfaces 2014-08, Vol.6 (16), p.13510-13519 |
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| container_title | ACS applied materials & interfaces |
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| creator | Zhao, Yiliang Lawrie, Jenifer L Beavers, Kelsey R Laibinis, Paul E Weiss, Sharon M |
| description | This work examines the influence of charge density and surface passivation on the DNA-induced corrosion of porous silicon (PSi) waveguides in order to improve PSi biosensor sensitivity, reliability, and reproducibility when exposed to negatively charged DNA molecules. Increasing the concentration of either DNA probes or targets enhances the corrosion process and masks binding events. While passivation of the PSi surface by oxidation and silanization is shown to diminish the corrosion rate and lead to a saturation in the changes by corrosion after about 2 h, complete mitigation can be achieved by replacing the DNA probe molecules with charge-neutral PNA probe molecules. A model to explain the DNA-induced corrosion behavior, consistent with experimental characterization of the PSi through Fourier transform infrared spectroscopy and prism coupling optical measurements, is also introduced. |
| doi_str_mv | 10.1021/am502582s |
| format | Article |
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Increasing the concentration of either DNA probes or targets enhances the corrosion process and masks binding events. While passivation of the PSi surface by oxidation and silanization is shown to diminish the corrosion rate and lead to a saturation in the changes by corrosion after about 2 h, complete mitigation can be achieved by replacing the DNA probe molecules with charge-neutral PNA probe molecules. A model to explain the DNA-induced corrosion behavior, consistent with experimental characterization of the PSi through Fourier transform infrared spectroscopy and prism coupling optical measurements, is also introduced.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/am502582s</identifier><identifier>PMID: 25089918</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Biosensing Techniques ; Corrosion ; DNA - chemistry ; DNA Probes - chemistry ; Magnesium - chemistry ; Optical Phenomena ; Peptide Nucleic Acids - chemistry ; Porosity ; Silanes - chemistry ; Silicon - chemistry ; Spectroscopy, Fourier Transform Infrared</subject><ispartof>ACS applied materials & interfaces, 2014-08, Vol.6 (16), p.13510-13519</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a315t-cc757fe65fdd5b8e26b418c09c000759ad6dba9cce567477ccbdea7fd8d37bc53</citedby><cites>FETCH-LOGICAL-a315t-cc757fe65fdd5b8e26b418c09c000759ad6dba9cce567477ccbdea7fd8d37bc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/am502582s$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/am502582s$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25089918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Yiliang</creatorcontrib><creatorcontrib>Lawrie, Jenifer L</creatorcontrib><creatorcontrib>Beavers, Kelsey R</creatorcontrib><creatorcontrib>Laibinis, Paul E</creatorcontrib><creatorcontrib>Weiss, Sharon M</creatorcontrib><title>Effect of DNA-Induced Corrosion on Passivated Porous Silicon Biosensors</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. 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A model to explain the DNA-induced corrosion behavior, consistent with experimental characterization of the PSi through Fourier transform infrared spectroscopy and prism coupling optical measurements, is also introduced.</description><subject>Biosensing Techniques</subject><subject>Corrosion</subject><subject>DNA - chemistry</subject><subject>DNA Probes - chemistry</subject><subject>Magnesium - chemistry</subject><subject>Optical Phenomena</subject><subject>Peptide Nucleic Acids - chemistry</subject><subject>Porosity</subject><subject>Silanes - chemistry</subject><subject>Silicon - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkNFLwzAQxoMobk4f_AekL4I-VJM0adLHOeccDB2ozyW9JNDRNjNpBf97I5t7Eg7uuPvxcd-H0CXBdwRTcq9ajimXNByhMSkYSyXl9PgwMzZCZyFsMM4zivkpGlGOZVEQOUaLubUG-sTZ5PFlmi47PYDRycx570LtuiTWWoVQf6k-7tfOuyEkb3VTQ7w81C6YLjgfztGJVU0wF_s-QR9P8_fZc7p6XSxn01WqMsL7FEBwYU3Orda8kobmFSMScAEYY8ELpXNdqQLA8FwwIQAqbZSwWupMVMCzCbrZ6W69-xxM6Mu2DmCaRnUmflYSziUnkjES0dsdCtFK8MaWW1-3yn-XBJe_uZWH3CJ7tZcdqtboA_kXVASud4CCUG7c4Lvo8h-hHyPgdHs</recordid><startdate>20140827</startdate><enddate>20140827</enddate><creator>Zhao, Yiliang</creator><creator>Lawrie, Jenifer L</creator><creator>Beavers, Kelsey R</creator><creator>Laibinis, Paul E</creator><creator>Weiss, Sharon M</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140827</creationdate><title>Effect of DNA-Induced Corrosion on Passivated Porous Silicon Biosensors</title><author>Zhao, Yiliang ; Lawrie, Jenifer L ; Beavers, Kelsey R ; Laibinis, Paul E ; Weiss, Sharon M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a315t-cc757fe65fdd5b8e26b418c09c000759ad6dba9cce567477ccbdea7fd8d37bc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biosensing Techniques</topic><topic>Corrosion</topic><topic>DNA - chemistry</topic><topic>DNA Probes - chemistry</topic><topic>Magnesium - chemistry</topic><topic>Optical Phenomena</topic><topic>Peptide Nucleic Acids - chemistry</topic><topic>Porosity</topic><topic>Silanes - chemistry</topic><topic>Silicon - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yiliang</creatorcontrib><creatorcontrib>Lawrie, Jenifer L</creatorcontrib><creatorcontrib>Beavers, Kelsey R</creatorcontrib><creatorcontrib>Laibinis, Paul E</creatorcontrib><creatorcontrib>Weiss, Sharon M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yiliang</au><au>Lawrie, Jenifer L</au><au>Beavers, Kelsey R</au><au>Laibinis, Paul E</au><au>Weiss, Sharon M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of DNA-Induced Corrosion on Passivated Porous Silicon Biosensors</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2014-08-27</date><risdate>2014</risdate><volume>6</volume><issue>16</issue><spage>13510</spage><epage>13519</epage><pages>13510-13519</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>This work examines the influence of charge density and surface passivation on the DNA-induced corrosion of porous silicon (PSi) waveguides in order to improve PSi biosensor sensitivity, reliability, and reproducibility when exposed to negatively charged DNA molecules. Increasing the concentration of either DNA probes or targets enhances the corrosion process and masks binding events. While passivation of the PSi surface by oxidation and silanization is shown to diminish the corrosion rate and lead to a saturation in the changes by corrosion after about 2 h, complete mitigation can be achieved by replacing the DNA probe molecules with charge-neutral PNA probe molecules. 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| subjects | Biosensing Techniques Corrosion DNA - chemistry DNA Probes - chemistry Magnesium - chemistry Optical Phenomena Peptide Nucleic Acids - chemistry Porosity Silanes - chemistry Silicon - chemistry Spectroscopy, Fourier Transform Infrared |
| title | Effect of DNA-Induced Corrosion on Passivated Porous Silicon Biosensors |
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