Lipoprotein-Associated Phospholipase A2 Regulates Macrophage Apoptosis via the Akt and Caspase-7 Pathways

Aim: Mutations in lipoprotein-associated phospholipase A2 (Lp-PLA2) are related to atherosclerosis. However, the molecular effects of Lp-PLA2 on atherosclerosis have not been fully investigated. Therefore, this study attempted to elucidate this issue. Methods: Monocytes were isolated from randomly s...

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Veröffentlicht in:	Journal of Atherosclerosis and Thrombosis 2014/08/26, Vol.21(8), pp.839-853
Hauptverfasser:	Maeda, Toshinaga, Takeuchi, Keisuke, Xiaoling, Pang, Zankov, Dimitar P., Takashima, Naoyuki, Fujiyoshi, Akira, Kadowaki, Takashi, Miura, Katsuyuki, Ueshima, Hirotsugu, Ogita, Hisakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism Adult Aged Animals Apoptosis Atherosclerosis Blotting, Western Caspase 7 - metabolism Cell Proliferation Cells, Cultured Cercopithecus aethiops COS Cells Flow Cytometry Heterozygote Humans Lipoproteins, LDL - metabolism Macrophage Macrophages - metabolism Macrophages - pathology Male Middle Aged Monocytes - metabolism Monocytes - pathology Mutation - genetics Phospholipase Proto-Oncogene Proteins c-akt - metabolism Real-Time Polymerase Chain Reaction
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