Improved prediction of carcinogenic potencies from mutagenic potencies for chemicals positive in rodents and the ames test

Most studies of correlation between logs of mutagenic potency (MP) and cancer potency (CP) have obtained relatively small but statistically significant estimates of correlation (r) and corresponding log‐log slope (b, in Log[CP] = a + b Log[)MP]). But for mutagenic carcinogens, multistage cancer theo...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1995, Vol.25 (1), p.37-49
1. Verfasser:	Bogen, Kenneth T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogens Chemical mutagenesis correlation Databases, Factual dose-response Dose-Response Relationship, Drug In Vitro Techniques linear Medical sciences Microsomes, Liver - metabolism mouse multistage model Mutagenicity Tests - standards Mutagens - administration & dosage rat Rats Regression Analysis Salmonella - drug effects slope Toxicology
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