Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam
The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy). After this the rats received either the agonist, diazepam, or the antagonist, flumazenil (Ro 15-1788...
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| Veröffentlicht in: | European journal of pharmacology 1990-03, Vol.178 (1), p.111-114 |
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| container_title | European journal of pharmacology |
| container_volume | 178 |
| creator | Peeters, Bernard W.M.M. Van Rijn, Clementina M. Nutt, David J. Titulaer, Miriam N.G. Vossen, Joseph M.H. Coenen, Anton M.L. |
| description | The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy). After this the rats received either the agonist, diazepam, or the antagonist, flumazenil (Ro 15-1788). EEG analyses showed that both compounds increased the amount of absence epilepsy-like phenomena. This suggests that repeated administration of diazepam moves the benzodiazepine receptor spectrum towards the inverse agonist end. |
| doi_str_mv | 10.1016/0014-2999(90)94801-4 |
| format | Article |
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After this the rats received either the agonist, diazepam, or the antagonist, flumazenil (Ro 15-1788). EEG analyses showed that both compounds increased the amount of absence epilepsy-like phenomena. This suggests that repeated administration of diazepam moves the benzodiazepine receptor spectrum towards the inverse agonist end.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(90)94801-4</identifier><identifier>PMID: 2110065</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Diazepam ; Diazepam - pharmacology ; Electroencephalography ; Epilepsy (non-convulsive) ; Epilepsy - chemically induced ; Epilepsy - genetics ; Epilepsy - physiopathology ; Flumazenil - pharmacology ; Hypnotics and Sedatives ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Ro 15-1788 ; Tolerance ; WAG/Rij inbred strain</subject><ispartof>European journal of pharmacology, 1990-03, Vol.178 (1), p.111-114</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-a225e66191ce7fd9a3da9b2f4fe95eb30b6d95dc523d60c247b210906e65c57c3</citedby><cites>FETCH-LOGICAL-c417t-a225e66191ce7fd9a3da9b2f4fe95eb30b6d95dc523d60c247b210906e65c57c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299990948014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6920042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2110065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peeters, Bernard W.M.M.</creatorcontrib><creatorcontrib>Van Rijn, Clementina M.</creatorcontrib><creatorcontrib>Nutt, David J.</creatorcontrib><creatorcontrib>Titulaer, Miriam N.G.</creatorcontrib><creatorcontrib>Vossen, Joseph M.H.</creatorcontrib><creatorcontrib>Coenen, Anton M.L.</creatorcontrib><title>Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy). After this the rats received either the agonist, diazepam, or the antagonist, flumazenil (Ro 15-1788). EEG analyses showed that both compounds increased the amount of absence epilepsy-like phenomena. This suggests that repeated administration of diazepam moves the benzodiazepine receptor spectrum towards the inverse agonist end.</description><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Diazepam</subject><subject>Diazepam - pharmacology</subject><subject>Electroencephalography</subject><subject>Epilepsy (non-convulsive)</subject><subject>Epilepsy - chemically induced</subject><subject>Epilepsy - genetics</subject><subject>Epilepsy - physiopathology</subject><subject>Flumazenil - pharmacology</subject><subject>Hypnotics and Sedatives</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Ro 15-1788</subject><subject>Tolerance</subject><subject>WAG/Rij inbred strain</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAURUVoSSdp_kEKWpSSLNy8J0uytSmEfLUQKISWLoUsPVMFj-1KntLpr68nY2bZ1Vvccy-Pw9g5wkcE1FcAKAthjLkwcGlkDVjII7bCujIFVChesdUBecNOcn4GAGWEOmbHAhFAqxVzt9H9pdGtuesDfxo4qgKruuax94lcJu6aTL0nTmPsaMzbOeE_rh-unuIzT27K3P9MQx-967otpz_jkCnwaeBhGX7LXreuy3S23FP2_f7u283n4vHrw5eb68fCS6ymwgmhSGs06Klqg3FlcKYRrWzJKGpKaHQwKnglyqDBC1k1AsGAJq28qnx5yj7sd8c0_NpQnuw6Zk9d53oaNtmiUrWoy3oG5R70acg5UWvHFNcubS2C3Zm1O212p80asC9mrZxr75b9TbOmcCgtKuf8_ZK7PMtok-t9zAdMGwEgxYx92mM0u_gdKdns405wiIn8ZMMQ___HP3PCkwE</recordid><startdate>19900313</startdate><enddate>19900313</enddate><creator>Peeters, Bernard W.M.M.</creator><creator>Van Rijn, Clementina M.</creator><creator>Nutt, David J.</creator><creator>Titulaer, Miriam N.G.</creator><creator>Vossen, Joseph M.H.</creator><creator>Coenen, Anton M.L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19900313</creationdate><title>Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam</title><author>Peeters, Bernard W.M.M. ; Van Rijn, Clementina M. ; Nutt, David J. ; Titulaer, Miriam N.G. ; Vossen, Joseph M.H. ; Coenen, Anton M.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-a225e66191ce7fd9a3da9b2f4fe95eb30b6d95dc523d60c247b210906e65c57c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Diazepam</topic><topic>Diazepam - pharmacology</topic><topic>Electroencephalography</topic><topic>Epilepsy (non-convulsive)</topic><topic>Epilepsy - chemically induced</topic><topic>Epilepsy - genetics</topic><topic>Epilepsy - physiopathology</topic><topic>Flumazenil - pharmacology</topic><topic>Hypnotics and Sedatives</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. 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| ispartof | European journal of pharmacology, 1990-03, Vol.178 (1), p.111-114 |
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| language | eng |
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| subjects | Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Diazepam Diazepam - pharmacology Electroencephalography Epilepsy (non-convulsive) Epilepsy - chemically induced Epilepsy - genetics Epilepsy - physiopathology Flumazenil - pharmacology Hypnotics and Sedatives Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Ro 15-1788 Tolerance WAG/Rij inbred strain |
| title | Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam |
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