Interaction of 1-methyl-4-phenylpyridinium ion with human platelets

When uptake of the Parkinson's syndrome inducing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its major brain metabolite MPP + (1-methyl-4-phenylpyridinium ion) by human platelets were compared in platelet rich plasma, a much higher rate was observed for the metabolite. Th...

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Veröffentlicht in:	Biochemical and biophysical research communications 1988-03, Vol.151 (2), p.897-904
Hauptverfasser:	Buckman, Trent D., Chang, Ruth, Sutphin, Mary S., Eiduson, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenylpyridinium Adenosine Triphosphate - blood Biological and medical sciences Biological Transport Blood coagulation. Blood cells Blood Platelets - metabolism Fundamental and applied biological sciences. Psychology Humans Kinetics Molecular and cellular biology Neurotoxins - blood Platelet Pyridines - blood Pyridinium Compounds - blood Rotenone - pharmacology Serotonin Antagonists - pharmacology
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