Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

Interleukin-6 (IL-6) and gamma-interferon (IFNgamma) activate an overlapping set of genes via the Jak/STAT pathway. However, at least in human cells, a differential activation of STAT transcription factors was observed: IL-6 activates both acute phase response factor (APRF)/STAT3 and STAT1, whereas...

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Veröffentlicht in:	The Journal of biological chemistry 1996-05, Vol.271 (22), p.12991-12998
Hauptverfasser:	Gerhartz, C, Heesel, B, Sasse, J, Hemmann, U, Landgraf, C, Schneider-Mergener, J, Horn, F, Heinrich, P C, Graeve, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Amino Acid Sequence Animals Antigens, CD - chemistry Antigens, CD - metabolism Base Sequence Cell Line Cytokine Receptor gp130 Cytoplasm - metabolism DNA-Binding Proteins - metabolism Humans Interleukin-6 - metabolism Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Molecular Sequence Data Mutagenesis, Site-Directed Oligodeoxyribonucleotides Phosphotyrosine - metabolism Signal Transduction STAT1 Transcription Factor STAT3 Transcription Factor Trans-Activators - metabolism
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