Tumor Dormancy and Cell Signaling: Anti-μ -Induced Apoptosis in Human B-Lymphoma Cells is not Caused by an APO-1-APO-1 Ligand Interaction
Signal transduction initiated by crosslinking of antigen-specific receptors on T- and B-lymphoma cells induces apoptosis. In T-lymphoma cells, such crosslinking results in upregulation of the APO-1 ligand, which then interacts with induced or constitutively expressed APO-1, thereby triggering apopto...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1996-03, Vol.93 (5), p.2165-2168 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Racila, Emilian Hsueh, Robert Marches, Radu Tucker, Thomas F. Krammer, Peter H. Scheuermann, Richard H. Uhr, Jonathan W. |
| description | Signal transduction initiated by crosslinking of antigen-specific receptors on T- and B-lymphoma cells induces apoptosis. In T-lymphoma cells, such crosslinking results in upregulation of the APO-1 ligand, which then interacts with induced or constitutively expressed APO-1, thereby triggering apoptosis. Here we show that crosslinking the membrane immunoglobulin on human lymphoma cells (Daudi) (that constitutively express APO-1) does not induce synthesis of APO-1 ligand. Further, a noncytotoxic fragment of anti-APO-1 antibody that blocks T-cell-receptor-mediated apoptosis in T-lymphoma cells does not block anti-μ -induced apoptosis. Hence, in B-lymphoma cells, apoptosis induced by signaling via membrane IgM is not mediated by the APO-1 ligand. |
| doi_str_mv | 10.1073/pnas.93.5.2165 |
| format | Article |
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In T-lymphoma cells, such crosslinking results in upregulation of the APO-1 ligand, which then interacts with induced or constitutively expressed APO-1, thereby triggering apoptosis. Here we show that crosslinking the membrane immunoglobulin on human lymphoma cells (Daudi) (that constitutively express APO-1) does not induce synthesis of APO-1 ligand. Further, a noncytotoxic fragment of anti-APO-1 antibody that blocks T-cell-receptor-mediated apoptosis in T-lymphoma cells does not block anti-μ -induced apoptosis. Hence, in B-lymphoma cells, apoptosis induced by signaling via membrane IgM is not mediated by the APO-1 ligand.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.93.5.2165</identifier><identifier>PMID: 8700902</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Antibodies ; Apoptosis ; B-Lymphocytes - cytology ; B-Lymphocytes - immunology ; Base Sequence ; Cell cycle ; Crosslinking ; Delta cells ; DNA Primers - chemistry ; fas Receptor - physiology ; Humans ; Immunity (Disease) ; Immunoglobulin mu-Chains ; Ligands ; Lymphocyte Activation ; Medical research ; Membranes ; Messenger RNA ; Molecular Sequence Data ; Receptors ; Receptors, Antigen, B-Cell - physiology ; Signal Transduction ; T cell lymphoma ; T lymphocytes ; T-Lymphocytes - cytology ; T-Lymphocytes - immunology ; Tumor Cells, Cultured</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1996-03, Vol.93 (5), p.2165-2168</ispartof><rights>Copyright 1996 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Mar 5, 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-cbafe96fac9408ad67bd316d30396545c8332245b6b6e8bca98f284edda3a1913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/93/5.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/38484$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/38484$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27915,27916,53782,53784,58008,58241</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8700902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Racila, Emilian</creatorcontrib><creatorcontrib>Hsueh, Robert</creatorcontrib><creatorcontrib>Marches, Radu</creatorcontrib><creatorcontrib>Tucker, Thomas F.</creatorcontrib><creatorcontrib>Krammer, Peter H.</creatorcontrib><creatorcontrib>Scheuermann, Richard H.</creatorcontrib><creatorcontrib>Uhr, Jonathan W.</creatorcontrib><title>Tumor Dormancy and Cell Signaling: Anti-μ -Induced Apoptosis in Human B-Lymphoma Cells is not Caused by an APO-1-APO-1 Ligand Interaction</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Signal transduction initiated by crosslinking of antigen-specific receptors on T- and B-lymphoma cells induces apoptosis. In T-lymphoma cells, such crosslinking results in upregulation of the APO-1 ligand, which then interacts with induced or constitutively expressed APO-1, thereby triggering apoptosis. Here we show that crosslinking the membrane immunoglobulin on human lymphoma cells (Daudi) (that constitutively express APO-1) does not induce synthesis of APO-1 ligand. Further, a noncytotoxic fragment of anti-APO-1 antibody that blocks T-cell-receptor-mediated apoptosis in T-lymphoma cells does not block anti-μ -induced apoptosis. Hence, in B-lymphoma cells, apoptosis induced by signaling via membrane IgM is not mediated by the APO-1 ligand.</description><subject>Antibodies</subject><subject>Apoptosis</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - immunology</subject><subject>Base Sequence</subject><subject>Cell cycle</subject><subject>Crosslinking</subject><subject>Delta cells</subject><subject>DNA Primers - chemistry</subject><subject>fas Receptor - physiology</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Immunoglobulin mu-Chains</subject><subject>Ligands</subject><subject>Lymphocyte Activation</subject><subject>Medical research</subject><subject>Membranes</subject><subject>Messenger RNA</subject><subject>Molecular Sequence Data</subject><subject>Receptors</subject><subject>Receptors, Antigen, B-Cell - physiology</subject><subject>Signal Transduction</subject><subject>T cell lymphoma</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Cells, Cultured</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuO0zAUhi3EaCgDWxZISBYLdim-xImN2JQCM5UqDRLD2nIcp-MqsTO2g-gr8Ew8A89EMi1VQUhsbEv_9x3fDgDPMJpjVNLXvVNxLuiczQku2AMww0jgrMgFeghmCJEy4znJH4HHMW4RQoJxdA7OeTkuEZmB7zdD5wN870OnnN5B5Wq4NG0LP9uNU611mzdw4ZLNfv6A2crVgzY1XPS-Tz7aCK2DV8NownfZetf1t75T9_qYROh8gks1xNGopspw8ek6w9n9CNd2M-21cskEpZP17gk4a1QbzdPDfAG-fPxws7zK1teXq-VinWmGacp0pRojikZpkSOu6qKsaoqLmiIqCpYzzSklJGdVURWGV1oJ3hCem7pWVGGB6QV4u6_bD1Vnam1cCqqVfbCdCjvplZV_Js7eyo3_KqkQhI_6q4Me_N1gYpKdjXq8s3LGD1GWHAsuSPFfEDNWclJO4Mu_wK0fwvj6URKECS8EYiM030M6-BiDaY4HxkhOnSCnTpCCSianThiFF6fXPOKHrz853uT9To--bIa2TeZbOin0T3DMn-_zbUw-HAHKc57TX-s00Cc</recordid><startdate>19960305</startdate><enddate>19960305</enddate><creator>Racila, Emilian</creator><creator>Hsueh, Robert</creator><creator>Marches, Radu</creator><creator>Tucker, Thomas F.</creator><creator>Krammer, Peter H.</creator><creator>Scheuermann, Richard H.</creator><creator>Uhr, Jonathan W.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960305</creationdate><title>Tumor Dormancy and Cell Signaling: Anti-μ -Induced Apoptosis in Human B-Lymphoma Cells is not Caused by an APO-1-APO-1 Ligand Interaction</title><author>Racila, Emilian ; 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| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Antibodies Apoptosis B-Lymphocytes - cytology B-Lymphocytes - immunology Base Sequence Cell cycle Crosslinking Delta cells DNA Primers - chemistry fas Receptor - physiology Humans Immunity (Disease) Immunoglobulin mu-Chains Ligands Lymphocyte Activation Medical research Membranes Messenger RNA Molecular Sequence Data Receptors Receptors, Antigen, B-Cell - physiology Signal Transduction T cell lymphoma T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - immunology Tumor Cells, Cultured |
| title | Tumor Dormancy and Cell Signaling: Anti-μ -Induced Apoptosis in Human B-Lymphoma Cells is not Caused by an APO-1-APO-1 Ligand Interaction |
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