Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation

In this study we have examined the immunostimulatory effects of the macrocyclic lactone bryostatin 1 on various aspects of B cell activation and proliferation using human tonsillar B cells. Bryostatin 1 is an activator of protein kinase C (PKC) and its properties were compared to those of the classi...

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Veröffentlicht in:	European journal of immunology 1990-01, Vol.20 (1), p.119-127
Hauptverfasser:	Drexler, Hans G., Gignac, Suzanne M., Pettit, George R., Hoffbrand, A. Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Antibody Formation - drug effects B-Lymphocytes - cytology B-Lymphocytes - physiology Biological and medical sciences Bryostatins Calcimycin - pharmacology Cell Cycle - drug effects Cyclosporins - pharmacology DNA - biosynthesis Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology In Vitro Techniques Isoquinolines - pharmacology Lactones - pharmacology Lymphocyte Activation - drug effects Macrolides Modulation of the immune response (stimulation, suppression) Piperazines - pharmacology Protein Kinase C - metabolism RNA - biosynthesis Tetradecanoylphorbol Acetate - pharmacology
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