Distal Single Subcortical Infarction Had a Better Clinical Outcome Compared With Proximal Single Subcortical Infarction
BACKGROUND AND PURPOSE—Single subcortical infarction (SSI) may be classified as proximal SSI (pSSI) or distal SSI (dSSI) according to its location within the middle cerebral artery territory. Few studies have examined the differences in clinical outcome between the two. Our study investigated such d...
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| Veröffentlicht in: | Stroke (1970) 2014-09, Vol.45 (9), p.2613-2619 |
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| container_title | Stroke (1970) |
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| creator | Zhang, Changqing Wang, Yilong Zhao, Xingquan Wang, David Liu, Liping Wang, Chunxue Pu, Yuehua Zou, Xinying Du, Wanliang Jing, Jing Pan, Yuesong Wong, Ka Sing Wang, Yongjun |
| description | BACKGROUND AND PURPOSE—Single subcortical infarction (SSI) may be classified as proximal SSI (pSSI) or distal SSI (dSSI) according to its location within the middle cerebral artery territory. Few studies have examined the differences in clinical outcome between the two. Our study investigated such differences in patients with pSSI or dSSI and examined their baseline characteristics and indicators for small-vessel disease.
METHODS—We prospectively enrolled 400 patients with SSI (208 pSSI and 192 dSSI) who had no middle cerebral artery disease on MR angiography. Data compared included clinical information, lesion size, prevalence of lacune and leukoaraiosis at baseline, National Institutes of Health Stroke Scale score and modified Rankin Scale score at discharge, and any deterioration during admission or recurrence of ischemic stroke |
| doi_str_mv | 10.1161/STROKEAHA.114.005634 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1557081629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1557081629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5264-f93de26ded11977d77b7f50596d2caaa9670b17b67cd5c39d9d0729285e7f4653</originalsourceid><addsrcrecordid>eNqFkMtuEzEUQK0K1IbCH1TIG6RuptgeP8bLNC2kolIQKWI58tiextQzTm2PAn-PS0LZwerqXp37OgCcYXSBMcfv13dfVp-u58t5SekFQozX9AjMMCO0opw0L8AMoVpWhEp5Al6l9B0hROqGHYMTwhAjNRYzsLtyKSsP12689xaup06HmJ0upZuxV1FnF0a4VAYqeGlzthEuvBt_A6sp6zBYuAjDVkVr4DeXN_BzDD_c8L-Rr8HLXvlk3xziKfj64fpusaxuVx9vFvPbSjPCadXL2ljCjTUYSyGMEJ3oy_GSG6KVUpIL1GHRcaEN07U00iBBJGmYFT3lrD4F5_u52xgeJ5tyO7ikrfdqtGFKLWZMoAZzIgtK96iOIaVo-3YbyyPxZ4tR-6S8fVZeUtrulZe2t4cNUzdY89z0x3EB3h0AlYqEPqpRu_SXa4QgFD_tb_bcLvjiOT34aWdju7HK582_b_gFxKyczw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1557081629</pqid></control><display><type>article</type><title>Distal Single Subcortical Infarction Had a Better Clinical Outcome Compared With Proximal Single Subcortical Infarction</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Zhang, Changqing ; Wang, Yilong ; Zhao, Xingquan ; Wang, David ; Liu, Liping ; Wang, Chunxue ; Pu, Yuehua ; Zou, Xinying ; Du, Wanliang ; Jing, Jing ; Pan, Yuesong ; Wong, Ka Sing ; Wang, Yongjun</creator><creatorcontrib>Zhang, Changqing ; Wang, Yilong ; Zhao, Xingquan ; Wang, David ; Liu, Liping ; Wang, Chunxue ; Pu, Yuehua ; Zou, Xinying ; Du, Wanliang ; Jing, Jing ; Pan, Yuesong ; Wong, Ka Sing ; Wang, Yongjun ; Chinese Intracranial Atherosclerosis Study Group</creatorcontrib><description>BACKGROUND AND PURPOSE—Single subcortical infarction (SSI) may be classified as proximal SSI (pSSI) or distal SSI (dSSI) according to its location within the middle cerebral artery territory. Few studies have examined the differences in clinical outcome between the two. Our study investigated such differences in patients with pSSI or dSSI and examined their baseline characteristics and indicators for small-vessel disease.
METHODS—We prospectively enrolled 400 patients with SSI (208 pSSI and 192 dSSI) who had no middle cerebral artery disease on MR angiography. Data compared included clinical information, lesion size, prevalence of lacune and leukoaraiosis at baseline, National Institutes of Health Stroke Scale score and modified Rankin Scale score at discharge, and any deterioration during admission or recurrence of ischemic stroke <1 year.
RESULTS—In multivariable logistic regression analysis, dSSI was independently associated with patient’s history of stroke, admission National Institutes of Health Stroke Scale score ≤3, Fazekas score ≥3, presence of lacune, but not hyperlipidemia. Patients with dSSI had shorter length of hospital stay, lower rate of functional dependence at discharge (modified Rankin Scale score ≥2), and lower deterioration or recurrence risk of ischemic stroke in 1 year. Multivariable logistic regression analysis showed that factors associated with higher deterioration or recurrence risk of ischemic stroke at 1 year included female sex, history of coronary heart disease, pSSI, and not on antithrombotics <48 hours of admission.
CONCLUSIONS—Compared with pSSI, patients with dSSI likely had small-vessel diseases but better clinical outcome.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.114.005634</identifier><identifier>PMID: 25052317</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cerebral Infarction - mortality ; Cerebral Infarction - therapy ; Female ; Humans ; Infarction, Middle Cerebral Artery - mortality ; Infarction, Middle Cerebral Artery - therapy ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Neurology ; Prospective Studies ; Radionuclide investigations ; Recurrence ; Regression Analysis ; Risk Factors ; Stroke - mortality ; Stroke - therapy ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system ; Young Adult</subject><ispartof>Stroke (1970), 2014-09, Vol.45 (9), p.2613-2619</ispartof><rights>2014 American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5264-f93de26ded11977d77b7f50596d2caaa9670b17b67cd5c39d9d0729285e7f4653</citedby><cites>FETCH-LOGICAL-c5264-f93de26ded11977d77b7f50596d2caaa9670b17b67cd5c39d9d0729285e7f4653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28772419$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25052317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Changqing</creatorcontrib><creatorcontrib>Wang, Yilong</creatorcontrib><creatorcontrib>Zhao, Xingquan</creatorcontrib><creatorcontrib>Wang, David</creatorcontrib><creatorcontrib>Liu, Liping</creatorcontrib><creatorcontrib>Wang, Chunxue</creatorcontrib><creatorcontrib>Pu, Yuehua</creatorcontrib><creatorcontrib>Zou, Xinying</creatorcontrib><creatorcontrib>Du, Wanliang</creatorcontrib><creatorcontrib>Jing, Jing</creatorcontrib><creatorcontrib>Pan, Yuesong</creatorcontrib><creatorcontrib>Wong, Ka Sing</creatorcontrib><creatorcontrib>Wang, Yongjun</creatorcontrib><creatorcontrib>Chinese Intracranial Atherosclerosis Study Group</creatorcontrib><title>Distal Single Subcortical Infarction Had a Better Clinical Outcome Compared With Proximal Single Subcortical Infarction</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—Single subcortical infarction (SSI) may be classified as proximal SSI (pSSI) or distal SSI (dSSI) according to its location within the middle cerebral artery territory. Few studies have examined the differences in clinical outcome between the two. Our study investigated such differences in patients with pSSI or dSSI and examined their baseline characteristics and indicators for small-vessel disease.
METHODS—We prospectively enrolled 400 patients with SSI (208 pSSI and 192 dSSI) who had no middle cerebral artery disease on MR angiography. Data compared included clinical information, lesion size, prevalence of lacune and leukoaraiosis at baseline, National Institutes of Health Stroke Scale score and modified Rankin Scale score at discharge, and any deterioration during admission or recurrence of ischemic stroke <1 year.
RESULTS—In multivariable logistic regression analysis, dSSI was independently associated with patient’s history of stroke, admission National Institutes of Health Stroke Scale score ≤3, Fazekas score ≥3, presence of lacune, but not hyperlipidemia. Patients with dSSI had shorter length of hospital stay, lower rate of functional dependence at discharge (modified Rankin Scale score ≥2), and lower deterioration or recurrence risk of ischemic stroke in 1 year. Multivariable logistic regression analysis showed that factors associated with higher deterioration or recurrence risk of ischemic stroke at 1 year included female sex, history of coronary heart disease, pSSI, and not on antithrombotics <48 hours of admission.
CONCLUSIONS—Compared with pSSI, patients with dSSI likely had small-vessel diseases but better clinical outcome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cerebral Infarction - mortality</subject><subject>Cerebral Infarction - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Infarction, Middle Cerebral Artery - mortality</subject><subject>Infarction, Middle Cerebral Artery - therapy</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Angiography</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Prospective Studies</subject><subject>Radionuclide investigations</subject><subject>Recurrence</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Stroke - mortality</subject><subject>Stroke - therapy</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Young Adult</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtuEzEUQK0K1IbCH1TIG6RuptgeP8bLNC2kolIQKWI58tiextQzTm2PAn-PS0LZwerqXp37OgCcYXSBMcfv13dfVp-u58t5SekFQozX9AjMMCO0opw0L8AMoVpWhEp5Al6l9B0hROqGHYMTwhAjNRYzsLtyKSsP12689xaup06HmJ0upZuxV1FnF0a4VAYqeGlzthEuvBt_A6sp6zBYuAjDVkVr4DeXN_BzDD_c8L-Rr8HLXvlk3xziKfj64fpusaxuVx9vFvPbSjPCadXL2ljCjTUYSyGMEJ3oy_GSG6KVUpIL1GHRcaEN07U00iBBJGmYFT3lrD4F5_u52xgeJ5tyO7ikrfdqtGFKLWZMoAZzIgtK96iOIaVo-3YbyyPxZ4tR-6S8fVZeUtrulZe2t4cNUzdY89z0x3EB3h0AlYqEPqpRu_SXa4QgFD_tb_bcLvjiOT34aWdju7HK582_b_gFxKyczw</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Zhang, Changqing</creator><creator>Wang, Yilong</creator><creator>Zhao, Xingquan</creator><creator>Wang, David</creator><creator>Liu, Liping</creator><creator>Wang, Chunxue</creator><creator>Pu, Yuehua</creator><creator>Zou, Xinying</creator><creator>Du, Wanliang</creator><creator>Jing, Jing</creator><creator>Pan, Yuesong</creator><creator>Wong, Ka Sing</creator><creator>Wang, Yongjun</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Distal Single Subcortical Infarction Had a Better Clinical Outcome Compared With Proximal Single Subcortical Infarction</title><author>Zhang, Changqing ; Wang, Yilong ; Zhao, Xingquan ; Wang, David ; Liu, Liping ; Wang, Chunxue ; Pu, Yuehua ; Zou, Xinying ; Du, Wanliang ; Jing, Jing ; Pan, Yuesong ; Wong, Ka Sing ; Wang, Yongjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5264-f93de26ded11977d77b7f50596d2caaa9670b17b67cd5c39d9d0729285e7f4653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cerebral Infarction - mortality</topic><topic>Cerebral Infarction - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Infarction, Middle Cerebral Artery - mortality</topic><topic>Infarction, Middle Cerebral Artery - therapy</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Angiography</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Prospective Studies</topic><topic>Radionuclide investigations</topic><topic>Recurrence</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Stroke - mortality</topic><topic>Stroke - therapy</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Changqing</creatorcontrib><creatorcontrib>Wang, Yilong</creatorcontrib><creatorcontrib>Zhao, Xingquan</creatorcontrib><creatorcontrib>Wang, David</creatorcontrib><creatorcontrib>Liu, Liping</creatorcontrib><creatorcontrib>Wang, Chunxue</creatorcontrib><creatorcontrib>Pu, Yuehua</creatorcontrib><creatorcontrib>Zou, Xinying</creatorcontrib><creatorcontrib>Du, Wanliang</creatorcontrib><creatorcontrib>Jing, Jing</creatorcontrib><creatorcontrib>Pan, Yuesong</creatorcontrib><creatorcontrib>Wong, Ka Sing</creatorcontrib><creatorcontrib>Wang, Yongjun</creatorcontrib><creatorcontrib>Chinese Intracranial Atherosclerosis Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Changqing</au><au>Wang, Yilong</au><au>Zhao, Xingquan</au><au>Wang, David</au><au>Liu, Liping</au><au>Wang, Chunxue</au><au>Pu, Yuehua</au><au>Zou, Xinying</au><au>Du, Wanliang</au><au>Jing, Jing</au><au>Pan, Yuesong</au><au>Wong, Ka Sing</au><au>Wang, Yongjun</au><aucorp>Chinese Intracranial Atherosclerosis Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distal Single Subcortical Infarction Had a Better Clinical Outcome Compared With Proximal Single Subcortical Infarction</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2014-09</date><risdate>2014</risdate><volume>45</volume><issue>9</issue><spage>2613</spage><epage>2619</epage><pages>2613-2619</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>BACKGROUND AND PURPOSE—Single subcortical infarction (SSI) may be classified as proximal SSI (pSSI) or distal SSI (dSSI) according to its location within the middle cerebral artery territory. Few studies have examined the differences in clinical outcome between the two. Our study investigated such differences in patients with pSSI or dSSI and examined their baseline characteristics and indicators for small-vessel disease.
METHODS—We prospectively enrolled 400 patients with SSI (208 pSSI and 192 dSSI) who had no middle cerebral artery disease on MR angiography. Data compared included clinical information, lesion size, prevalence of lacune and leukoaraiosis at baseline, National Institutes of Health Stroke Scale score and modified Rankin Scale score at discharge, and any deterioration during admission or recurrence of ischemic stroke <1 year.
RESULTS—In multivariable logistic regression analysis, dSSI was independently associated with patient’s history of stroke, admission National Institutes of Health Stroke Scale score ≤3, Fazekas score ≥3, presence of lacune, but not hyperlipidemia. Patients with dSSI had shorter length of hospital stay, lower rate of functional dependence at discharge (modified Rankin Scale score ≥2), and lower deterioration or recurrence risk of ischemic stroke in 1 year. Multivariable logistic regression analysis showed that factors associated with higher deterioration or recurrence risk of ischemic stroke at 1 year included female sex, history of coronary heart disease, pSSI, and not on antithrombotics <48 hours of admission.
CONCLUSIONS—Compared with pSSI, patients with dSSI likely had small-vessel diseases but better clinical outcome.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>25052317</pmid><doi>10.1161/STROKEAHA.114.005634</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Cerebral Infarction - mortality Cerebral Infarction - therapy Female Humans Infarction, Middle Cerebral Artery - mortality Infarction, Middle Cerebral Artery - therapy Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Angiography Magnetic Resonance Imaging Male Medical sciences Middle Aged Nervous system Neurology Prospective Studies Radionuclide investigations Recurrence Regression Analysis Risk Factors Stroke - mortality Stroke - therapy Treatment Outcome Vascular diseases and vascular malformations of the nervous system Young Adult |
| title | Distal Single Subcortical Infarction Had a Better Clinical Outcome Compared With Proximal Single Subcortical Infarction |
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