Effects of 5-hydroxytryptamine applied into nucleus raphe magnus on nociceptive thresholds and neuronal firing rate
The effect of iontophoretically applied 5-hydroxytryptamine on neurones in nucleus raphe magnus, and the effect of microinjection of 5-hydroxytryptamine into nucleus raphe magnus on nociceptive thresholds were examined in the rat. Iontophoretically applied 5-hydroxytryptamine excited 66% and inhibit...
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| Veröffentlicht in: | Brain research 1983-01, Vol.258 (1), p.59-68 |
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| creator | Llewelyn, Meirion B. Azami, John Roberts, Malcolm H.T. |
| description | The effect of iontophoretically applied 5-hydroxytryptamine on neurones in nucleus raphe magnus, and the effect of microinjection of 5-hydroxytryptamine into nucleus raphe magnus on nociceptive thresholds were examined in the rat. Iontophoretically applied 5-hydroxytryptamine excited 66% and inhibited 6% of the neurones encountered in the nucleus raphe magnus. The excitatory reponse to 5-hydroxytryptamine was reduced by the putative serotonergic antagonist cinanserin in 21 of 24 cases. In 12 of these neurones the responses to iontophoretically applied glutamate were also examined. In 11 of the 12 studies the responses to glutamate were reduced by cinanserin. Microinjection of 5 μg of 5-hydroxytryptamine into the nucleus raphe magnus produced analgesia as assessed by the tail-flick response to noxious heat stimulation, but no analgesia as assessed by the paw withdrawal response to pressure. Microinjection of 5 μg of 5-hydroxytryptamine into the adjacent nucleus reticularis paragigantocellularis had no analgesic effect in either test. These results indicate that 5-hydroxytryptamine mainly excites neurones in nucleus raphe magnus and that 5-hydroxytryptamine has an action on neurones in nucleus raphe magnus which modulate the nociceptive threshold. |
| doi_str_mv | 10.1016/0006-8993(83)91226-X |
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Iontophoretically applied 5-hydroxytryptamine excited 66% and inhibited 6% of the neurones encountered in the nucleus raphe magnus. The excitatory reponse to 5-hydroxytryptamine was reduced by the putative serotonergic antagonist cinanserin in 21 of 24 cases. In 12 of these neurones the responses to iontophoretically applied glutamate were also examined. In 11 of the 12 studies the responses to glutamate were reduced by cinanserin. Microinjection of 5 μg of 5-hydroxytryptamine into the nucleus raphe magnus produced analgesia as assessed by the tail-flick response to noxious heat stimulation, but no analgesia as assessed by the paw withdrawal response to pressure. Microinjection of 5 μg of 5-hydroxytryptamine into the adjacent nucleus reticularis paragigantocellularis had no analgesic effect in either test. These results indicate that 5-hydroxytryptamine mainly excites neurones in nucleus raphe magnus and that 5-hydroxytryptamine has an action on neurones in nucleus raphe magnus which modulate the nociceptive threshold.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(83)91226-X</identifier><identifier>PMID: 24010164</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>5-hydroxytryptamine ; Action Potentials - drug effects ; Action Potentials - physiology ; analgesia ; Analgesics, Opioid - pharmacology ; Animals ; Cinanserin - pharmacology ; Glutamic Acid - physiology ; Male ; Microinjections ; Morphine - pharmacology ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Nociceptors - drug effects ; Nociceptors - physiology ; nucleus raphe magnus ; Raphe Nuclei - drug effects ; Raphe Nuclei - physiology ; Rats ; Rats, Wistar ; Reaction Time - drug effects ; Reaction Time - physiology ; Serotonin - pharmacology ; Serotonin - physiology ; Serotonin Antagonists - pharmacology</subject><ispartof>Brain research, 1983-01, Vol.258 (1), p.59-68</ispartof><rights>1983 Elsevier Biomedical Press, Amtersdam</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-43da32a77dc51ec36f8bb9255cf8452ee0d1aa05dde2e4e8821bb3a1f52259583</citedby><cites>FETCH-LOGICAL-c422t-43da32a77dc51ec36f8bb9255cf8452ee0d1aa05dde2e4e8821bb3a1f52259583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(83)91226-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24010164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Llewelyn, Meirion B.</creatorcontrib><creatorcontrib>Azami, John</creatorcontrib><creatorcontrib>Roberts, Malcolm H.T.</creatorcontrib><title>Effects of 5-hydroxytryptamine applied into nucleus raphe magnus on nociceptive thresholds and neuronal firing rate</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effect of iontophoretically applied 5-hydroxytryptamine on neurones in nucleus raphe magnus, and the effect of microinjection of 5-hydroxytryptamine into nucleus raphe magnus on nociceptive thresholds were examined in the rat. Iontophoretically applied 5-hydroxytryptamine excited 66% and inhibited 6% of the neurones encountered in the nucleus raphe magnus. The excitatory reponse to 5-hydroxytryptamine was reduced by the putative serotonergic antagonist cinanserin in 21 of 24 cases. In 12 of these neurones the responses to iontophoretically applied glutamate were also examined. In 11 of the 12 studies the responses to glutamate were reduced by cinanserin. Microinjection of 5 μg of 5-hydroxytryptamine into the nucleus raphe magnus produced analgesia as assessed by the tail-flick response to noxious heat stimulation, but no analgesia as assessed by the paw withdrawal response to pressure. Microinjection of 5 μg of 5-hydroxytryptamine into the adjacent nucleus reticularis paragigantocellularis had no analgesic effect in either test. These results indicate that 5-hydroxytryptamine mainly excites neurones in nucleus raphe magnus and that 5-hydroxytryptamine has an action on neurones in nucleus raphe magnus which modulate the nociceptive threshold.</description><subject>5-hydroxytryptamine</subject><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>analgesia</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Cinanserin - pharmacology</subject><subject>Glutamic Acid - physiology</subject><subject>Male</subject><subject>Microinjections</subject><subject>Morphine - pharmacology</subject><subject>Naloxone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Nociceptors - drug effects</subject><subject>Nociceptors - physiology</subject><subject>nucleus raphe magnus</subject><subject>Raphe Nuclei - drug effects</subject><subject>Raphe Nuclei - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin - physiology</subject><subject>Serotonin Antagonists - pharmacology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1rFTEUhoMo9rb6D0SykroYzedMZiOUUqtQcKPQXcgkZ3ojM8mYZIr335vx1i6Lq3DI874HzoPQG0o-UELbj4SQtlF9z88Vf99Txtrm9hnaUdWxpmWCPEe7R-QEneb8s46c9-QlOqnfW4fYoXw1jmBLxnHEstkfXIq_DyUdlmJmHwCbZZk8OOxDiTisdoI142SWPeDZ3IU6xIBDtN7CUvw94LJPkPdxchmb4HCANcVgJjz65MNdjRZ4hV6MZsrw-uE9Qz8-X32__NLcfLv-enlx01jBWGkEd4Yz03XOSgqWt6Mahp5JaUclJAMgjhpDpHPAQIBSjA4DN3SUjMleKn6G3h17lxR_rZCLnn22ME0mQFyzplJ2RBHxPyDvaMcreP40KDhlPVfd1imOqE0x5wSjXpKfTTpoSvR2fL3Z0Zsdrbj-K1Df1tjbhw3rMIN7DP0zVoFPRwDq5e49JJ2th2DB-VRFahf90xv-AC9QrBo</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Llewelyn, Meirion B.</creator><creator>Azami, John</creator><creator>Roberts, Malcolm H.T.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>19830101</creationdate><title>Effects of 5-hydroxytryptamine applied into nucleus raphe magnus on nociceptive thresholds and neuronal firing rate</title><author>Llewelyn, Meirion B. ; Azami, John ; Roberts, Malcolm H.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-43da32a77dc51ec36f8bb9255cf8452ee0d1aa05dde2e4e8821bb3a1f52259583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>5-hydroxytryptamine</topic><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>analgesia</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Cinanserin - pharmacology</topic><topic>Glutamic Acid - physiology</topic><topic>Male</topic><topic>Microinjections</topic><topic>Morphine - pharmacology</topic><topic>Naloxone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Nociceptors - drug effects</topic><topic>Nociceptors - physiology</topic><topic>nucleus raphe magnus</topic><topic>Raphe Nuclei - drug effects</topic><topic>Raphe Nuclei - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin - physiology</topic><topic>Serotonin Antagonists - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Llewelyn, Meirion B.</creatorcontrib><creatorcontrib>Azami, John</creatorcontrib><creatorcontrib>Roberts, Malcolm H.T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Llewelyn, Meirion B.</au><au>Azami, John</au><au>Roberts, Malcolm H.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 5-hydroxytryptamine applied into nucleus raphe magnus on nociceptive thresholds and neuronal firing rate</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>258</volume><issue>1</issue><spage>59</spage><epage>68</epage><pages>59-68</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>The effect of iontophoretically applied 5-hydroxytryptamine on neurones in nucleus raphe magnus, and the effect of microinjection of 5-hydroxytryptamine into nucleus raphe magnus on nociceptive thresholds were examined in the rat. Iontophoretically applied 5-hydroxytryptamine excited 66% and inhibited 6% of the neurones encountered in the nucleus raphe magnus. The excitatory reponse to 5-hydroxytryptamine was reduced by the putative serotonergic antagonist cinanserin in 21 of 24 cases. In 12 of these neurones the responses to iontophoretically applied glutamate were also examined. In 11 of the 12 studies the responses to glutamate were reduced by cinanserin. Microinjection of 5 μg of 5-hydroxytryptamine into the nucleus raphe magnus produced analgesia as assessed by the tail-flick response to noxious heat stimulation, but no analgesia as assessed by the paw withdrawal response to pressure. Microinjection of 5 μg of 5-hydroxytryptamine into the adjacent nucleus reticularis paragigantocellularis had no analgesic effect in either test. These results indicate that 5-hydroxytryptamine mainly excites neurones in nucleus raphe magnus and that 5-hydroxytryptamine has an action on neurones in nucleus raphe magnus which modulate the nociceptive threshold.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24010164</pmid><doi>10.1016/0006-8993(83)91226-X</doi><tpages>10</tpages></addata></record> |
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| subjects | 5-hydroxytryptamine Action Potentials - drug effects Action Potentials - physiology analgesia Analgesics, Opioid - pharmacology Animals Cinanserin - pharmacology Glutamic Acid - physiology Male Microinjections Morphine - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Nociceptors - drug effects Nociceptors - physiology nucleus raphe magnus Raphe Nuclei - drug effects Raphe Nuclei - physiology Rats Rats, Wistar Reaction Time - drug effects Reaction Time - physiology Serotonin - pharmacology Serotonin - physiology Serotonin Antagonists - pharmacology |
| title | Effects of 5-hydroxytryptamine applied into nucleus raphe magnus on nociceptive thresholds and neuronal firing rate |
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