Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

(S)-10-(2,6-Dimethyl-4-pyridinyl) 9-fluoro-3-methyl-7-oxo 2,3-dihydro-7H-pyrido[1,2,3-de] [1,4]benzothiazine-6-carboxylic acid (WIN 58161) is an enantiomerically pure quinolone with outstanding bacterial topoisomerase II (DNA gyrase, EC 5.99.1.3) inhibitory and antibacterial activity. Unlike most qu...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical pharmacology 1995-06, Vol.50 (1), p.111-122
Hauptverfasser:	COUGHLIN, S. A, DANZ, D. W, RAKE, J. B, ROBINSON, R. G, KLINGBEIL, K. M, WENTLAND, M. P, CORBETT, T. H, WAUD, W. R, ZWELLING, L. A, ALTSCHULER, E, BALES, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Chemotherapy Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!