Acquired Von Willebrand Syndrome Secondary to Mitral and Aortic Regurgitation
Abstract The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovas...
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| Veröffentlicht in: | Canadian journal of cardiology 2014-09, Vol.30 (9), p.1108.e9-1108.e10 |
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| container_end_page | 1108.e10 |
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| container_issue | 9 |
| container_start_page | 1108.e9 |
| container_title | Canadian journal of cardiology |
| container_volume | 30 |
| creator | Wan, Siu-Hin, MD Liang, Jackson J., DO Vaidya, Rakhee, MBBS Blackshear, Joseph L., MD Chen, Dong, MD, PhD |
| description | Abstract The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from high shear forces, and desmopressin leads to transient clinical improvement. |
| doi_str_mv | 10.1016/j.cjca.2014.02.010 |
| format | Article |
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We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from high shear forces, and desmopressin leads to transient clinical improvement.</description><identifier>ISSN: 0828-282X</identifier><identifier>EISSN: 1916-7075</identifier><identifier>DOI: 10.1016/j.cjca.2014.02.010</identifier><identifier>PMID: 24994586</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aortic Valve Insufficiency - complications ; Aortic Valve Insufficiency - etiology ; Cardiovascular ; Endocarditis - complications ; Humans ; Male ; Middle Aged ; Mitral Valve Insufficiency - complications ; von Willebrand Diseases - etiology</subject><ispartof>Canadian journal of cardiology, 2014-09, Vol.30 (9), p.1108.e9-1108.e10</ispartof><rights>Canadian Cardiovascular Society</rights><rights>2014 Canadian Cardiovascular Society</rights><rights>Copyright © 2014 Canadian Cardiovascular Society. Published by Elsevier Inc. 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We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from high shear forces, and desmopressin leads to transient clinical improvement.</description><subject>Aortic Valve Insufficiency - complications</subject><subject>Aortic Valve Insufficiency - etiology</subject><subject>Cardiovascular</subject><subject>Endocarditis - complications</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitral Valve Insufficiency - complications</subject><subject>von Willebrand Diseases - etiology</subject><issn>0828-282X</issn><issn>1916-7075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQhy0EokvhBTigHLkkjB3bcSSEtKr4JxWQ2LZwsxx7Ujlk49ZOkPZteBaerI62cODAaS6_76eZbwh5TqGiQOWrobKDNRUDyitgFVB4QDa0pbJsoBEPyQYUUyVT7PsJeZLSAMBp08jH5ITxtuVCyQ35vLW3i4_oiqswFd_8OGIXzeSK3WFyMeyx2KENkzPxUMyh-OTnaMYiB37_2oY4e1t8xeslXvvZzD5MT8mj3owJn93PU3L57u3F2Yfy_Mv7j2fb89JyRedS5FUaCyhrY7GBrqet6jmKvgOJRnStUdxy7mgvXesUdrSRincMahCtMKI-JS-PvTcx3C6YZr33yeI4mgnDkjQVQjLVqBpylB2jNoaUIvb6Jvp9vkdT0KtHPejVo149amA6e8zQi_v-pduj-4v8EZcDr48BzFf-9Bh1sh4niy7LtLN2wf-__80_uB395K0Zf-AB0xCWOGV_muqUAb1bP7k-knLIOOf1HegmmWc</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Wan, Siu-Hin, MD</creator><creator>Liang, Jackson J., DO</creator><creator>Vaidya, Rakhee, MBBS</creator><creator>Blackshear, Joseph L., MD</creator><creator>Chen, Dong, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Acquired Von Willebrand Syndrome Secondary to Mitral and Aortic Regurgitation</title><author>Wan, Siu-Hin, MD ; Liang, Jackson J., DO ; Vaidya, Rakhee, MBBS ; Blackshear, Joseph L., MD ; Chen, Dong, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-50047c0e63ace70bf198f4e5fb06ea5b9a84c44d1f6d9d8eb17684b2030595a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aortic Valve Insufficiency - complications</topic><topic>Aortic Valve Insufficiency - etiology</topic><topic>Cardiovascular</topic><topic>Endocarditis - complications</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitral Valve Insufficiency - complications</topic><topic>von Willebrand Diseases - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wan, Siu-Hin, MD</creatorcontrib><creatorcontrib>Liang, Jackson J., DO</creatorcontrib><creatorcontrib>Vaidya, Rakhee, MBBS</creatorcontrib><creatorcontrib>Blackshear, Joseph L., MD</creatorcontrib><creatorcontrib>Chen, Dong, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wan, Siu-Hin, MD</au><au>Liang, Jackson J., DO</au><au>Vaidya, Rakhee, MBBS</au><au>Blackshear, Joseph L., MD</au><au>Chen, Dong, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acquired Von Willebrand Syndrome Secondary to Mitral and Aortic Regurgitation</atitle><jtitle>Canadian journal of cardiology</jtitle><addtitle>Can J Cardiol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>30</volume><issue>9</issue><spage>1108.e9</spage><epage>1108.e10</epage><pages>1108.e9-1108.e10</pages><issn>0828-282X</issn><eissn>1916-7075</eissn><abstract>Abstract The association between aortic stenosis and gastrointenstinal bleeding due to acquired von Willebrand syndrome (AVWS) has been well established. We report a patient with AVWS from underlying severe endocarditis-associated aortic regurgitation and pre-existing mitral regurgitation. Cardiovascular disease-related AVWS occurs from a selective loss of the largest multimers of von Willebrand factor from high shear forces, and desmopressin leads to transient clinical improvement.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>24994586</pmid><doi>10.1016/j.cjca.2014.02.010</doi></addata></record> |
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| identifier | ISSN: 0828-282X |
| ispartof | Canadian journal of cardiology, 2014-09, Vol.30 (9), p.1108.e9-1108.e10 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aortic Valve Insufficiency - complications Aortic Valve Insufficiency - etiology Cardiovascular Endocarditis - complications Humans Male Middle Aged Mitral Valve Insufficiency - complications von Willebrand Diseases - etiology |
| title | Acquired Von Willebrand Syndrome Secondary to Mitral and Aortic Regurgitation |
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