Oxycodone recycling: A novel hypothesis of opioid tolerance development in humans

Abstract We hypothesize that oxycodone (OC) recycling promotes sustained synaptic OC content, which prolongs OC’s exposure to local μ-opioid receptors ( μ ORs). In that way, OC recycling gives rise to OC tolerance in humans. To pilot test our hypothesis, we developed a whole-body OC mass transport t...

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Veröffentlicht in:	Medical hypotheses 2014-09, Vol.83 (3), p.326-331
Hauptverfasser:	Linares, Oscar A, Fudin, Jeffrey, Schiesser, William E, Daly Linares, Annemarie, Boston, Raymond C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Alleles Analgesics, Opioid - pharmacokinetics Biological Transport Cytochrome P-450 CYP2D6 - genetics Drug Tolerance Genotype Humans Internal Medicine Kinetics Male Opioid-Related Disorders - physiopathology Oxycodone - pharmacokinetics Phenotype Receptors, Opioid, mu - metabolism Time Factors Young Adult
Online-Zugang:	Volltext
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