Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction
Aortic-valve stenosis is a progressive condition; end-stage disease leads to death due to obstruction of left ventricular outflow. Aortic-valve replacement is the only effective therapy. Transcatheter aortic-valve replacement is appropriate in patients at very high surgical risk. Valvular aortic ste...
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| Veröffentlicht in: | The New England journal of medicine 2014-08, Vol.371 (8), p.744-756 |
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| container_title | The New England journal of medicine |
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| creator | Otto, Catherine M Prendergast, Bernard |
| description | Aortic-valve stenosis is a progressive condition; end-stage disease leads to death due to obstruction of left ventricular outflow. Aortic-valve replacement is the only effective therapy. Transcatheter aortic-valve replacement is appropriate in patients at very high surgical risk.
Valvular aortic stenosis is a progressive disease in which the end stage is characterized by obstruction of left ventricular outflow, resulting in inadequate cardiac output, decreased exercise capacity, heart failure, and death from cardiovascular causes. The prevalence of aortic stenosis is only about 0.2% among adults between the ages of 50 and 59 years but increases to 9.8% in octogenarians, with an overall prevalence of 2.8% in adults older than 75 years of age.
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Although mortality is not increased when aortic stenosis is asymptomatic, the rate of death is more than 50% at 2 years for patients with symptomatic . . . |
| doi_str_mv | 10.1056/NEJMra1313875 |
| format | Article |
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Valvular aortic stenosis is a progressive disease in which the end stage is characterized by obstruction of left ventricular outflow, resulting in inadequate cardiac output, decreased exercise capacity, heart failure, and death from cardiovascular causes. The prevalence of aortic stenosis is only about 0.2% among adults between the ages of 50 and 59 years but increases to 9.8% in octogenarians, with an overall prevalence of 2.8% in adults older than 75 years of age.
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Although mortality is not increased when aortic stenosis is asymptomatic, the rate of death is more than 50% at 2 years for patients with symptomatic . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMra1313875</identifier><identifier>PMID: 25140960</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Age ; Aortic Valve Stenosis - classification ; Aortic Valve Stenosis - physiopathology ; Aortic Valve Stenosis - surgery ; Biological and medical sciences ; Calcification ; Cardiology ; Cardiovascular disease ; Coronary vessels ; Disease Progression ; General aspects ; Heart ; Heart surgery ; Heart Valve Prosthesis Implantation ; Humans ; Lipoproteins ; Medical sciences ; Mortality ; Risk Factors ; Stenosis ; Ventricle ; Ventricular Function, Left</subject><ispartof>The New England journal of medicine, 2014-08, Vol.371 (8), p.744-756</ispartof><rights>Copyright © 2014 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-3a6c0ef05696a394b3146bd0033f981874a48103d375ec3c7e752ac0fc99d9a93</citedby><cites>FETCH-LOGICAL-c491t-3a6c0ef05696a394b3146bd0033f981874a48103d375ec3c7e752ac0fc99d9a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMra1313875$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1555299240?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28759472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25140960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otto, Catherine M</creatorcontrib><creatorcontrib>Prendergast, Bernard</creatorcontrib><title>Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Aortic-valve stenosis is a progressive condition; end-stage disease leads to death due to obstruction of left ventricular outflow. Aortic-valve replacement is the only effective therapy. Transcatheter aortic-valve replacement is appropriate in patients at very high surgical risk.
Valvular aortic stenosis is a progressive disease in which the end stage is characterized by obstruction of left ventricular outflow, resulting in inadequate cardiac output, decreased exercise capacity, heart failure, and death from cardiovascular causes. The prevalence of aortic stenosis is only about 0.2% among adults between the ages of 50 and 59 years but increases to 9.8% in octogenarians, with an overall prevalence of 2.8% in adults older than 75 years of age.
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Although mortality is not increased when aortic stenosis is asymptomatic, the rate of death is more than 50% at 2 years for patients with symptomatic . . .</description><subject>Age</subject><subject>Aortic Valve Stenosis - classification</subject><subject>Aortic Valve Stenosis - physiopathology</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Biological and medical sciences</subject><subject>Calcification</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Disease Progression</subject><subject>General aspects</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Heart Valve Prosthesis Implantation</subject><subject>Humans</subject><subject>Lipoproteins</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Risk Factors</subject><subject>Stenosis</subject><subject>Ventricle</subject><subject>Ventricular Function, Left</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10E9LwzAYBvAgipvTo1cJiOClmjRJ2xzH2Pw3nTj1WtI0hcy2mUk68OaH8BP6SaxuOhR8L7n88rwvDwD7GJ1gxKLTm-HltRWYYJLEbAN0MSMkoBRFm6CLUJgENOakA3acm6F2MOXboBMyTBGPUBdc9Y31WgaPolwoOPWqNk47-P76BkfWVPBWeK1q76Dw8E67J-gNnKqFsgouv0wy520jvTb1LtgqROnU3urtgYfR8H5wHownZxeD_jiQlGMfEBFJpIr2eB4JwmlGMI2yHCFCCp7gJKaCJhiRnMRMSSJjFbNQSFRIznMuOOmB42Xu3JrnRjmfVtpJVZaiVqZxKWaMRWHCcNLSwz90Zhpbt9d9qZDzkKJWBUslrXHOqiKdW10J-5JilH62nP5qufUHq9Qmq1T-o79rbcHRCggnRVlYUUvt1q4N4TQO166qXFqrWfXPwg9S245r</recordid><startdate>20140821</startdate><enddate>20140821</enddate><creator>Otto, Catherine M</creator><creator>Prendergast, Bernard</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140821</creationdate><title>Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction</title><author>Otto, Catherine M ; 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end-stage disease leads to death due to obstruction of left ventricular outflow. Aortic-valve replacement is the only effective therapy. Transcatheter aortic-valve replacement is appropriate in patients at very high surgical risk.
Valvular aortic stenosis is a progressive disease in which the end stage is characterized by obstruction of left ventricular outflow, resulting in inadequate cardiac output, decreased exercise capacity, heart failure, and death from cardiovascular causes. The prevalence of aortic stenosis is only about 0.2% among adults between the ages of 50 and 59 years but increases to 9.8% in octogenarians, with an overall prevalence of 2.8% in adults older than 75 years of age.
1
,
2
Although mortality is not increased when aortic stenosis is asymptomatic, the rate of death is more than 50% at 2 years for patients with symptomatic . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>25140960</pmid><doi>10.1056/NEJMra1313875</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland |
| subjects | Age Aortic Valve Stenosis - classification Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - surgery Biological and medical sciences Calcification Cardiology Cardiovascular disease Coronary vessels Disease Progression General aspects Heart Heart surgery Heart Valve Prosthesis Implantation Humans Lipoproteins Medical sciences Mortality Risk Factors Stenosis Ventricle Ventricular Function, Left |
| title | Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction |
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