Evaluation of acetylcholinesterase activity and behavioural alterations induced by ketamine in an animal model of schizophrenia
Cognitive deficits in schizophrenia play a crucial role in its clinical manifestation and seem to be related to changes in the cholinergic system, specifically the action of acetylcholinesterase (AChE). Considering this context, the aim of this study was to evaluate the chronic effects of ketamine i...
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| Veröffentlicht in: | Acta neuropsychiatrica 2014-02, Vol.26 (1), p.43-50 |
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| creator | Zugno, Alexandra I. Matos, Maria Paula Canever, Leila Fraga, Daiane B. De Luca, Renata D. Ghedim, Fernando V. Deroza, Pedro F. de Oliveira, Mariana B. Pacheco, Felipe D. Valvassori, Samira S. Volpato, Ana Maria Budni, Josiane Quevedo, João |
| description | Cognitive deficits in schizophrenia play a crucial role in its clinical manifestation and seem to be related to changes in the cholinergic system, specifically the action of acetylcholinesterase (AChE). Considering this context, the aim of this study was to evaluate the chronic effects of ketamine in the activity of AChE, as well as in behavioural parameters involving learning and memory.
The ketamine was administered for 7 days. A duration of 24 h after the last injection, the animals were submitted to behavioural tests. The activity of AChE in prefrontal cortex, hippocampus and striatum was measured at different times after the last injection (1, 3, 6 and 24 h).
The results indicate that ketamine did not affect locomotor activity and stereotypical movements. However, a cognitive deficit was observed in these animals by examining their behaviour in inhibitory avoidance. In addition, an increase in AChE activity was observed in all structures analysed 1, 3 and 6 h after the last injection. Differently, serum activity of AChE was similar between groups.
Chronic administration of ketamine in an animal model of schizophrenia generates increased AChE levels in different brain tissues of rats that lead to cognitive deficits. Therefore, further studies are needed to elucidate the complex mechanisms associated with schizophrenia. |
| doi_str_mv | 10.1017/neu.2013.31 |
| format | Article |
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The ketamine was administered for 7 days. A duration of 24 h after the last injection, the animals were submitted to behavioural tests. The activity of AChE in prefrontal cortex, hippocampus and striatum was measured at different times after the last injection (1, 3, 6 and 24 h).
The results indicate that ketamine did not affect locomotor activity and stereotypical movements. However, a cognitive deficit was observed in these animals by examining their behaviour in inhibitory avoidance. In addition, an increase in AChE activity was observed in all structures analysed 1, 3 and 6 h after the last injection. Differently, serum activity of AChE was similar between groups.
Chronic administration of ketamine in an animal model of schizophrenia generates increased AChE levels in different brain tissues of rats that lead to cognitive deficits. Therefore, further studies are needed to elucidate the complex mechanisms associated with schizophrenia.</description><identifier>ISSN: 0924-2708</identifier><identifier>EISSN: 1601-5215</identifier><identifier>DOI: 10.1017/neu.2013.31</identifier><identifier>PMID: 25142099</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acetylcholinesterase - metabolism ; Alzheimer's disease ; Animal cognition ; Animals ; Brain - enzymology ; Corpus Striatum - enzymology ; Dementia ; Disease Models, Animal ; Enzymes ; Hippocampus - enzymology ; Ketamine ; Ketamine - toxicity ; Laboratories ; Male ; Memory ; Memory - drug effects ; Motor Activity - drug effects ; Nervous system ; Original Articles ; Prefrontal Cortex - enzymology ; Rats ; Rats, Wistar ; Schizophrenia ; Schizophrenia - chemically induced ; Schizophrenia - enzymology</subject><ispartof>Acta neuropsychiatrica, 2014-02, Vol.26 (1), p.43-50</ispartof><rights>Copyright © Scandinavian College of Neuropsychopharmacology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-1936117edc11e8cf6c4389184e7cc301db15b20f45fe3335c7a7631167fccc143</citedby><cites>FETCH-LOGICAL-c355t-1936117edc11e8cf6c4389184e7cc301db15b20f45fe3335c7a7631167fccc143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0924270813000318/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,781,785,27928,27929,55632</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25142099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zugno, Alexandra I.</creatorcontrib><creatorcontrib>Matos, Maria Paula</creatorcontrib><creatorcontrib>Canever, Leila</creatorcontrib><creatorcontrib>Fraga, Daiane B.</creatorcontrib><creatorcontrib>De Luca, Renata D.</creatorcontrib><creatorcontrib>Ghedim, Fernando V.</creatorcontrib><creatorcontrib>Deroza, Pedro F.</creatorcontrib><creatorcontrib>de Oliveira, Mariana B.</creatorcontrib><creatorcontrib>Pacheco, Felipe D.</creatorcontrib><creatorcontrib>Valvassori, Samira S.</creatorcontrib><creatorcontrib>Volpato, Ana Maria</creatorcontrib><creatorcontrib>Budni, Josiane</creatorcontrib><creatorcontrib>Quevedo, João</creatorcontrib><title>Evaluation of acetylcholinesterase activity and behavioural alterations induced by ketamine in an animal model of schizophrenia</title><title>Acta neuropsychiatrica</title><addtitle>Acta Neuropsychiatr</addtitle><description>Cognitive deficits in schizophrenia play a crucial role in its clinical manifestation and seem to be related to changes in the cholinergic system, specifically the action of acetylcholinesterase (AChE). Considering this context, the aim of this study was to evaluate the chronic effects of ketamine in the activity of AChE, as well as in behavioural parameters involving learning and memory.
The ketamine was administered for 7 days. A duration of 24 h after the last injection, the animals were submitted to behavioural tests. The activity of AChE in prefrontal cortex, hippocampus and striatum was measured at different times after the last injection (1, 3, 6 and 24 h).
The results indicate that ketamine did not affect locomotor activity and stereotypical movements. However, a cognitive deficit was observed in these animals by examining their behaviour in inhibitory avoidance. In addition, an increase in AChE activity was observed in all structures analysed 1, 3 and 6 h after the last injection. Differently, serum activity of AChE was similar between groups.
Chronic administration of ketamine in an animal model of schizophrenia generates increased AChE levels in different brain tissues of rats that lead to cognitive deficits. Therefore, further studies are needed to elucidate the complex mechanisms associated with schizophrenia.</description><subject>Acetylcholinesterase - metabolism</subject><subject>Alzheimer's disease</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Brain - enzymology</subject><subject>Corpus Striatum - enzymology</subject><subject>Dementia</subject><subject>Disease Models, Animal</subject><subject>Enzymes</subject><subject>Hippocampus - enzymology</subject><subject>Ketamine</subject><subject>Ketamine - toxicity</subject><subject>Laboratories</subject><subject>Male</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Motor Activity - drug effects</subject><subject>Nervous system</subject><subject>Original Articles</subject><subject>Prefrontal Cortex - enzymology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Schizophrenia</subject><subject>Schizophrenia - chemically induced</subject><subject>Schizophrenia - enzymology</subject><issn>0924-2708</issn><issn>1601-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkUFr3DAQhUVoSDZpT70HQy-F4K1Gsiz5GEKSFgK5pGchy-OuEtnaSPbC9tK_HplsWygFgWD0vTd6PEI-Al0DBfllxHnNKPA1hyOygppCKRiId2RFG1aVTFJ1Ss5SeqKZbig7IadMQMVo06zIr5ud8bOZXBiL0BfG4rT3dhO8GzFNGE3CPJzczk37woxd0eLG7FyYo_GF8QuxaFPhxm62mN_3xTNOZsj6PMuSfNyQ4SF06JcdyW7cz7DdRBydeU-Oe-MTfjjc5-T77c3j9dfy_uHu2_XVfWm5EFMJDa8BJHYWAJXta1tx1YCqUFrLKXQtiJbRvhI9cs6FlUbWHKCWvbUWKn5OPr_5bmN4mXM0Pbhk0XszYpiTBiFEzbhSPKOf_kGfctwx_04zqZSoJKtVpi7fKBtDShF7vY05Z9xroHrpRede9NKL5pDpi4Pn3A7Y_WF_F5GB8mBnhja67gf-3fo_w1fISplD</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Zugno, Alexandra I.</creator><creator>Matos, Maria Paula</creator><creator>Canever, Leila</creator><creator>Fraga, Daiane B.</creator><creator>De Luca, Renata D.</creator><creator>Ghedim, Fernando V.</creator><creator>Deroza, Pedro F.</creator><creator>de Oliveira, Mariana B.</creator><creator>Pacheco, Felipe D.</creator><creator>Valvassori, Samira S.</creator><creator>Volpato, Ana Maria</creator><creator>Budni, Josiane</creator><creator>Quevedo, João</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Evaluation of acetylcholinesterase activity and behavioural alterations induced by ketamine in an animal model of schizophrenia</title><author>Zugno, Alexandra I. ; 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Considering this context, the aim of this study was to evaluate the chronic effects of ketamine in the activity of AChE, as well as in behavioural parameters involving learning and memory.
The ketamine was administered for 7 days. A duration of 24 h after the last injection, the animals were submitted to behavioural tests. The activity of AChE in prefrontal cortex, hippocampus and striatum was measured at different times after the last injection (1, 3, 6 and 24 h).
The results indicate that ketamine did not affect locomotor activity and stereotypical movements. However, a cognitive deficit was observed in these animals by examining their behaviour in inhibitory avoidance. In addition, an increase in AChE activity was observed in all structures analysed 1, 3 and 6 h after the last injection. Differently, serum activity of AChE was similar between groups.
Chronic administration of ketamine in an animal model of schizophrenia generates increased AChE levels in different brain tissues of rats that lead to cognitive deficits. Therefore, further studies are needed to elucidate the complex mechanisms associated with schizophrenia.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>25142099</pmid><doi>10.1017/neu.2013.31</doi><tpages>8</tpages></addata></record> |
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| subjects | Acetylcholinesterase - metabolism Alzheimer's disease Animal cognition Animals Brain - enzymology Corpus Striatum - enzymology Dementia Disease Models, Animal Enzymes Hippocampus - enzymology Ketamine Ketamine - toxicity Laboratories Male Memory Memory - drug effects Motor Activity - drug effects Nervous system Original Articles Prefrontal Cortex - enzymology Rats Rats, Wistar Schizophrenia Schizophrenia - chemically induced Schizophrenia - enzymology |
| title | Evaluation of acetylcholinesterase activity and behavioural alterations induced by ketamine in an animal model of schizophrenia |
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