Tumor necrosis factor alpha in mycobacterial infection

Highlights • In TB, TNF-α is produced primarily by myeloid cells and also by lymphocytes and its availability is regulated by cytokines, enzymes, lipid mediators and miRNAs. • Local gradients dictate the detrimental or beneficial role of TNF-α by fine-tuning antibacterial capacities and tissue damag...

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Veröffentlicht in:	Seminars in immunology 2014-06, Vol.26 (3), p.203-209
Hauptverfasser:	Dorhoi, Anca, Kaufmann, Stefan H.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cell death Granuloma Humans Immunotherapy Inflammation Mycobacterium tuberculosis Mycobacterium tuberculosis - physiology Tuberculosis - drug therapy Tuberculosis - immunology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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