Effect of hydrophobicity of a drug on its release from hydrogels with different topological structures

The effect of the topological structure; that is, the network heterogeneity, of hydrophobically modified, slightly acidic hydrogels on the binding and release of low molar mass drugs has been studied using ibuprofen and ephedrine as model compounds with varying water solubility. The difference in th...

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Veröffentlicht in:	Journal of applied polymer science 1999-08, Vol.73 (6), p.1031-1039
Hauptverfasser:	Lowe, Tao Lu, Tenhu, Heikki, Tylli, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylics Applied sciences Biological and medical sciences Controlled drug delivery drug release Exact sciences and technology General pharmacology hydrophobic interaction Hydrophobicity Medical sciences N-isopropylacrylamide network heterogeneity Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Properties and characterization Solubility Solution and gel properties Structure (composition) Swelling
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