Evolutionary Analysis Identifies an MX2 Haplotype Associated with Natural Resistance to HIV-1 Infection

The protein product of the myxovirus resistance 2 (MX2) gene restricts HIV-1 and simian retroviruses. We demonstrate that MX2 evolved adaptively in mammals with distinct sites representing selection targets in distinct branches; selection mainly involved residues in loop 4, previously shown to carry...

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Veröffentlicht in:	Molecular biology and evolution 2014-09, Vol.31 (9), p.2402-2414
Hauptverfasser:	Sironi, Manuela, Biasin, Mara, Cagliani, Rachele, Gnudi, Federica, Saulle, Irma, Ibba, Salomè, Filippi, Giulia, Yahyaei, Sarah, Tresoldi, Claudia, Riva, Stefania, Trabattoni, Daria, De Gioia, Luca, Lo Caputo, Sergio, Mazzotta, Francesco, Forni, Diego, Pontremoli, Chiara, Pineda, Juan Antonio, Pozzoli, Uberto, Rivero-Juarez, Antonio, Caruz, Antonio, Clerici, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Asian Continental Ancestry Group - genetics Computational Biology - methods Disease Resistance European Continental Ancestry Group - genetics Evolution, Molecular Evolutionary biology Genetic Variation Genetics Haplotypes HIV HIV Infections - genetics HIV Infections - immunology HIV-1 - pathogenicity Human immunodeficiency virus Human populations Humans Melanoma Models, Genetic Molecular biology Myxovirus Resistance Proteins - chemistry Myxovirus Resistance Proteins - genetics Phylogeny Population genetics Selection, Genetic Viral infections
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