Noninducibility in Postinfarction Ventricular Tachycardia as an End Point for Ventricular Tachycardia Ablation and Its Effects on Outcomes: A Meta-Analysis
BACKGROUND—Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal end points for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of noninducibility of postinfarction VT for l...
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| Veröffentlicht in: | Circulation. Arrhythmia and electrophysiology 2014-08, Vol.7 (4), p.677-683 |
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| creator | Ghanbari, Hamid Baser, Kazim Yokokawa, Miki Stevenson, William Della Bella, Paolo Vergara, Pasquale Deneke, Thomas Kuck, Karl-Heinz Kottkamp, Hans Fei, She Morady, Fred Bogun, Frank |
| description | BACKGROUND—Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal end points for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of noninducibility of postinfarction VT for long-term outcomes after VT ablation.
METHODS AND RESULTS—We performed a systematic review of MEDLINE (1950–2013), EMBASE (1988–2013), the Cochrane Controlled Trials Register (Fourth Quarter, 2012), and reports presented at scientific meetings (1994–2013). Randomized controlled trials, case–control, and cohort studies of VT ablation were included. Outcomes reported in eligible studies were freedom from VT/ventricular fibrillation and all-cause mortality. Of the 3895 studies evaluated, we identified 8 cohort studies enrolling 928 patients for the meta-analysis. Noninducibility after VT ablation was associated with a significant increase in arrhythmia-free survival compared with partial success (odds ratio, 0.49; 95% confidence interval, 0.29–0.84; P=0.009) or failed ablation procedure (odds ratio, 0.10; 95% confidence interval, 0.06–0.18; P |
| doi_str_mv | 10.1161/CIRCEP.113.001404 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1555247863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1555247863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2980-c3d9b127d93ea1e7775181c3a5ed3b8d08be057c8858f43495714b18bc5d94eb3</originalsourceid><addsrcrecordid>eNp1kU9rVDEUxYMo9o9-ADeSpZtXk5dkkrgbhlEHqi1S3Yb8e0w0k9QkjzKfxS9r2te6c3G5h8vvHLgcAN5gdIHxCr_f7L5tttddkwuEMEX0GTjFkuKBIEGfP2lM5Qk4q_UnQiss8OolOBmp4JILeQr-fM0pJDfbYEIM7QhDgte5tpAmXWwLOcEfPrUS7Bx1gTfa7o9WFxc01BXqBLfJdUNIDU65_Jddm6gfwnTHd63C7TR523c_Xc3N5oOvH-AafvFND-uk47GG-gq8mHSs_vXjPgffP25vNp-Hy6tPu836crCjFGiwxEmDR-4k8Rp7zjnrb1qimXfECIeE8YhxKwQTEyVUMo6pwcJY5iT1hpyDd0vubcm_Z1-bOoRqfYw6-TxXhRljI-ViRTqKF9SWXGvxk7ot4aDLUWGk7jtRSyddE7V00j1vH-Nnc_Dun-OphA7QBbjLsflSf8X5zhe19zq2vUKYEE4lGcb7OIEQGvqMiPwF8VaZNg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1555247863</pqid></control><display><type>article</type><title>Noninducibility in Postinfarction Ventricular Tachycardia as an End Point for Ventricular Tachycardia Ablation and Its Effects on Outcomes: A Meta-Analysis</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Ghanbari, Hamid ; Baser, Kazim ; Yokokawa, Miki ; Stevenson, William ; Della Bella, Paolo ; Vergara, Pasquale ; Deneke, Thomas ; Kuck, Karl-Heinz ; Kottkamp, Hans ; Fei, She ; Morady, Fred ; Bogun, Frank</creator><creatorcontrib>Ghanbari, Hamid ; Baser, Kazim ; Yokokawa, Miki ; Stevenson, William ; Della Bella, Paolo ; Vergara, Pasquale ; Deneke, Thomas ; Kuck, Karl-Heinz ; Kottkamp, Hans ; Fei, She ; Morady, Fred ; Bogun, Frank</creatorcontrib><description>BACKGROUND—Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal end points for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of noninducibility of postinfarction VT for long-term outcomes after VT ablation.
METHODS AND RESULTS—We performed a systematic review of MEDLINE (1950–2013), EMBASE (1988–2013), the Cochrane Controlled Trials Register (Fourth Quarter, 2012), and reports presented at scientific meetings (1994–2013). Randomized controlled trials, case–control, and cohort studies of VT ablation were included. Outcomes reported in eligible studies were freedom from VT/ventricular fibrillation and all-cause mortality. Of the 3895 studies evaluated, we identified 8 cohort studies enrolling 928 patients for the meta-analysis. Noninducibility after VT ablation was associated with a significant increase in arrhythmia-free survival compared with partial success (odds ratio, 0.49; 95% confidence interval, 0.29–0.84; P=0.009) or failed ablation procedure (odds ratio, 0.10; 95% confidence interval, 0.06–0.18; P<0.001). There was also a significant reduction in all-cause mortality if patients were noninducible after VT ablation compared with patients with partial success (odds ratio, 0.59; 95% confidence interval, 0.36–0.98; P=0.04) or failed ablation (odds ratio, 0.32; 95% confidence interval, 0.10–0.99; P=0.049).
CONCLUSIONS—Noninducibility of VT after VT ablation is associated with improved arrhythmia-free survival and all-cause mortality.</description><identifier>ISSN: 1941-3149</identifier><identifier>EISSN: 1941-3084</identifier><identifier>DOI: 10.1161/CIRCEP.113.001404</identifier><identifier>PMID: 24879789</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Cardiac Pacing, Artificial ; Catheter Ablation - adverse effects ; Catheter Ablation - mortality ; Disease-Free Survival ; Electrophysiologic Techniques, Cardiac ; Humans ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Odds Ratio ; Predictive Value of Tests ; Recurrence ; Risk Assessment ; Risk Factors ; Tachycardia, Ventricular - diagnosis ; Tachycardia, Ventricular - etiology ; Tachycardia, Ventricular - mortality ; Tachycardia, Ventricular - physiopathology ; Tachycardia, Ventricular - surgery ; Time Factors ; Treatment Outcome</subject><ispartof>Circulation. Arrhythmia and electrophysiology, 2014-08, Vol.7 (4), p.677-683</ispartof><rights>2014 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2980-c3d9b127d93ea1e7775181c3a5ed3b8d08be057c8858f43495714b18bc5d94eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3685,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24879789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghanbari, Hamid</creatorcontrib><creatorcontrib>Baser, Kazim</creatorcontrib><creatorcontrib>Yokokawa, Miki</creatorcontrib><creatorcontrib>Stevenson, William</creatorcontrib><creatorcontrib>Della Bella, Paolo</creatorcontrib><creatorcontrib>Vergara, Pasquale</creatorcontrib><creatorcontrib>Deneke, Thomas</creatorcontrib><creatorcontrib>Kuck, Karl-Heinz</creatorcontrib><creatorcontrib>Kottkamp, Hans</creatorcontrib><creatorcontrib>Fei, She</creatorcontrib><creatorcontrib>Morady, Fred</creatorcontrib><creatorcontrib>Bogun, Frank</creatorcontrib><title>Noninducibility in Postinfarction Ventricular Tachycardia as an End Point for Ventricular Tachycardia Ablation and Its Effects on Outcomes: A Meta-Analysis</title><title>Circulation. Arrhythmia and electrophysiology</title><addtitle>Circ Arrhythm Electrophysiol</addtitle><description>BACKGROUND—Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal end points for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of noninducibility of postinfarction VT for long-term outcomes after VT ablation.
METHODS AND RESULTS—We performed a systematic review of MEDLINE (1950–2013), EMBASE (1988–2013), the Cochrane Controlled Trials Register (Fourth Quarter, 2012), and reports presented at scientific meetings (1994–2013). Randomized controlled trials, case–control, and cohort studies of VT ablation were included. Outcomes reported in eligible studies were freedom from VT/ventricular fibrillation and all-cause mortality. Of the 3895 studies evaluated, we identified 8 cohort studies enrolling 928 patients for the meta-analysis. Noninducibility after VT ablation was associated with a significant increase in arrhythmia-free survival compared with partial success (odds ratio, 0.49; 95% confidence interval, 0.29–0.84; P=0.009) or failed ablation procedure (odds ratio, 0.10; 95% confidence interval, 0.06–0.18; P<0.001). There was also a significant reduction in all-cause mortality if patients were noninducible after VT ablation compared with patients with partial success (odds ratio, 0.59; 95% confidence interval, 0.36–0.98; P=0.04) or failed ablation (odds ratio, 0.32; 95% confidence interval, 0.10–0.99; P=0.049).
CONCLUSIONS—Noninducibility of VT after VT ablation is associated with improved arrhythmia-free survival and all-cause mortality.</description><subject>Cardiac Pacing, Artificial</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheter Ablation - mortality</subject><subject>Disease-Free Survival</subject><subject>Electrophysiologic Techniques, Cardiac</subject><subject>Humans</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Recurrence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Tachycardia, Ventricular - diagnosis</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Tachycardia, Ventricular - mortality</subject><subject>Tachycardia, Ventricular - physiopathology</subject><subject>Tachycardia, Ventricular - surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1941-3149</issn><issn>1941-3084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9rVDEUxYMo9o9-ADeSpZtXk5dkkrgbhlEHqi1S3Yb8e0w0k9QkjzKfxS9r2te6c3G5h8vvHLgcAN5gdIHxCr_f7L5tttddkwuEMEX0GTjFkuKBIEGfP2lM5Qk4q_UnQiss8OolOBmp4JILeQr-fM0pJDfbYEIM7QhDgte5tpAmXWwLOcEfPrUS7Bx1gTfa7o9WFxc01BXqBLfJdUNIDU65_Jddm6gfwnTHd63C7TR523c_Xc3N5oOvH-AafvFND-uk47GG-gq8mHSs_vXjPgffP25vNp-Hy6tPu836crCjFGiwxEmDR-4k8Rp7zjnrb1qimXfECIeE8YhxKwQTEyVUMo6pwcJY5iT1hpyDd0vubcm_Z1-bOoRqfYw6-TxXhRljI-ViRTqKF9SWXGvxk7ot4aDLUWGk7jtRSyddE7V00j1vH-Nnc_Dun-OphA7QBbjLsflSf8X5zhe19zq2vUKYEE4lGcb7OIEQGvqMiPwF8VaZNg</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Ghanbari, Hamid</creator><creator>Baser, Kazim</creator><creator>Yokokawa, Miki</creator><creator>Stevenson, William</creator><creator>Della Bella, Paolo</creator><creator>Vergara, Pasquale</creator><creator>Deneke, Thomas</creator><creator>Kuck, Karl-Heinz</creator><creator>Kottkamp, Hans</creator><creator>Fei, She</creator><creator>Morady, Fred</creator><creator>Bogun, Frank</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Noninducibility in Postinfarction Ventricular Tachycardia as an End Point for Ventricular Tachycardia Ablation and Its Effects on Outcomes: A Meta-Analysis</title><author>Ghanbari, Hamid ; Baser, Kazim ; Yokokawa, Miki ; Stevenson, William ; Della Bella, Paolo ; Vergara, Pasquale ; Deneke, Thomas ; Kuck, Karl-Heinz ; Kottkamp, Hans ; Fei, She ; Morady, Fred ; Bogun, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2980-c3d9b127d93ea1e7775181c3a5ed3b8d08be057c8858f43495714b18bc5d94eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cardiac Pacing, Artificial</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheter Ablation - mortality</topic><topic>Disease-Free Survival</topic><topic>Electrophysiologic Techniques, Cardiac</topic><topic>Humans</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Recurrence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Tachycardia, Ventricular - diagnosis</topic><topic>Tachycardia, Ventricular - etiology</topic><topic>Tachycardia, Ventricular - mortality</topic><topic>Tachycardia, Ventricular - physiopathology</topic><topic>Tachycardia, Ventricular - surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghanbari, Hamid</creatorcontrib><creatorcontrib>Baser, Kazim</creatorcontrib><creatorcontrib>Yokokawa, Miki</creatorcontrib><creatorcontrib>Stevenson, William</creatorcontrib><creatorcontrib>Della Bella, Paolo</creatorcontrib><creatorcontrib>Vergara, Pasquale</creatorcontrib><creatorcontrib>Deneke, Thomas</creatorcontrib><creatorcontrib>Kuck, Karl-Heinz</creatorcontrib><creatorcontrib>Kottkamp, Hans</creatorcontrib><creatorcontrib>Fei, She</creatorcontrib><creatorcontrib>Morady, Fred</creatorcontrib><creatorcontrib>Bogun, Frank</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation. Arrhythmia and electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghanbari, Hamid</au><au>Baser, Kazim</au><au>Yokokawa, Miki</au><au>Stevenson, William</au><au>Della Bella, Paolo</au><au>Vergara, Pasquale</au><au>Deneke, Thomas</au><au>Kuck, Karl-Heinz</au><au>Kottkamp, Hans</au><au>Fei, She</au><au>Morady, Fred</au><au>Bogun, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninducibility in Postinfarction Ventricular Tachycardia as an End Point for Ventricular Tachycardia Ablation and Its Effects on Outcomes: A Meta-Analysis</atitle><jtitle>Circulation. Arrhythmia and electrophysiology</jtitle><addtitle>Circ Arrhythm Electrophysiol</addtitle><date>2014-08</date><risdate>2014</risdate><volume>7</volume><issue>4</issue><spage>677</spage><epage>683</epage><pages>677-683</pages><issn>1941-3149</issn><eissn>1941-3084</eissn><abstract>BACKGROUND—Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal end points for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of noninducibility of postinfarction VT for long-term outcomes after VT ablation.
METHODS AND RESULTS—We performed a systematic review of MEDLINE (1950–2013), EMBASE (1988–2013), the Cochrane Controlled Trials Register (Fourth Quarter, 2012), and reports presented at scientific meetings (1994–2013). Randomized controlled trials, case–control, and cohort studies of VT ablation were included. Outcomes reported in eligible studies were freedom from VT/ventricular fibrillation and all-cause mortality. Of the 3895 studies evaluated, we identified 8 cohort studies enrolling 928 patients for the meta-analysis. Noninducibility after VT ablation was associated with a significant increase in arrhythmia-free survival compared with partial success (odds ratio, 0.49; 95% confidence interval, 0.29–0.84; P=0.009) or failed ablation procedure (odds ratio, 0.10; 95% confidence interval, 0.06–0.18; P<0.001). There was also a significant reduction in all-cause mortality if patients were noninducible after VT ablation compared with patients with partial success (odds ratio, 0.59; 95% confidence interval, 0.36–0.98; P=0.04) or failed ablation (odds ratio, 0.32; 95% confidence interval, 0.10–0.99; P=0.049).
CONCLUSIONS—Noninducibility of VT after VT ablation is associated with improved arrhythmia-free survival and all-cause mortality.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>24879789</pmid><doi>10.1161/CIRCEP.113.001404</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1941-3149 |
| ispartof | Circulation. Arrhythmia and electrophysiology, 2014-08, Vol.7 (4), p.677-683 |
| issn | 1941-3149 1941-3084 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cardiac Pacing, Artificial Catheter Ablation - adverse effects Catheter Ablation - mortality Disease-Free Survival Electrophysiologic Techniques, Cardiac Humans Myocardial Infarction - complications Myocardial Infarction - mortality Odds Ratio Predictive Value of Tests Recurrence Risk Assessment Risk Factors Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - etiology Tachycardia, Ventricular - mortality Tachycardia, Ventricular - physiopathology Tachycardia, Ventricular - surgery Time Factors Treatment Outcome |
| title | Noninducibility in Postinfarction Ventricular Tachycardia as an End Point for Ventricular Tachycardia Ablation and Its Effects on Outcomes: A Meta-Analysis |
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