Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells

Despite progress in the understanding of the biology and genetics of melanoma, no effective treatment against this cancer is available. The adjacent microenvironment has an important role in melanoma progression. Defining the molecular signals that control the bidirectional dialog between malignant...

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Veröffentlicht in:	Oncogene 2014-06, Vol.33 (26), p.3364-3373
Hauptverfasser:	Albinet, V, Bats, M-L, Huwiler, A, Rochaix, P, Chevreau, C, Ségui, B, Levade, T, Andrieu-Abadie, N
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1813/1634 631/67/322 631/80/86 Aldehyde-Lyases - genetics Animals Apoptosis Cancer Cancer therapies Cell Biology Cell Communication - genetics Cell differentiation Cell Differentiation - genetics Cell interaction Cell interactions Cell migration Cell Movement Cell Transformation, Neoplastic - genetics Cells Enzymes Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases Female Fibroblasts Fibroblasts - enzymology Fibroblasts - pathology Gene Expression Profiling Genetic aspects GTP Phosphohydrolases - genetics HEK293 Cells Human Genetics Humans Immunohistochemistry Internal Medicine Kinases Lysophospholipids - metabolism Matrix metalloproteinase Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medicine Medicine & Public Health Melanocytes Melanoma Melanoma - enzymology Melanoma - pathology Membrane Proteins - genetics Mice Mice, Inbred C57BL Mice, Knockout Microenvironments Myofibroblasts - enzymology Myofibroblasts - pathology Oncology Oncology, Experimental original-article Phosphotransferases Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Properties Protein research Proto-Oncogene Proteins B-raf - genetics Regulation RNA Interference RNA, Messenger - biosynthesis RNA, Small Interfering Skin Skin Neoplasms - enzymology Skin Neoplasms - pathology Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine 1-phosphate Sphingosine kinase Stroma Therapeutic targets Transcriptomics Tumor cells Tumorigenesis
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